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A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: Diuretics In the Management of Essential hypertension (DIME) study.

Ueda S, Morimoto T, Ando S, Takishita S, Kawano Y, Shimamoto K, Ogihara T, Saruta T, DIME Investigato - BMJ Open (2014)

Bottom Line: Diabetes developed in 25 (4.6%) participants in the Diuretics group, as compared with 29 (4.9%) in the No-diuretics group (HR 0.93; 95% CI 0.55 to 1.58; p=0.800).Antihypertensive treatment with thiazide diuretics at low doses may not be associated with an increased risk for new onset of type 2 diabetes.This result might suggest safety of use of low doses of thiazide diuretics.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Okinawa, Japan.

No MeSH data available.


Related in: MedlinePlus

Plasma fasting glucose (A) and glycated hemoglobin (B) over time by groups.
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BMJOPEN2013004576F4: Plasma fasting glucose (A) and glycated hemoglobin (B) over time by groups.

Mentions: Averaged fasting plasma glucose concentrations and HbA1c levels overtime and at the end of follow-up period are shown in figure 4 and table 3, respectively. Levels of fasting glucose or HbA1c in the Diuretics group throughout the study were not significantly higher than those in the No-diuretics group.


A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: Diuretics In the Management of Essential hypertension (DIME) study.

Ueda S, Morimoto T, Ando S, Takishita S, Kawano Y, Shimamoto K, Ogihara T, Saruta T, DIME Investigato - BMJ Open (2014)

Plasma fasting glucose (A) and glycated hemoglobin (B) over time by groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120409&req=5

BMJOPEN2013004576F4: Plasma fasting glucose (A) and glycated hemoglobin (B) over time by groups.
Mentions: Averaged fasting plasma glucose concentrations and HbA1c levels overtime and at the end of follow-up period are shown in figure 4 and table 3, respectively. Levels of fasting glucose or HbA1c in the Diuretics group throughout the study were not significantly higher than those in the No-diuretics group.

Bottom Line: Diabetes developed in 25 (4.6%) participants in the Diuretics group, as compared with 29 (4.9%) in the No-diuretics group (HR 0.93; 95% CI 0.55 to 1.58; p=0.800).Antihypertensive treatment with thiazide diuretics at low doses may not be associated with an increased risk for new onset of type 2 diabetes.This result might suggest safety of use of low doses of thiazide diuretics.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Okinawa, Japan.

No MeSH data available.


Related in: MedlinePlus