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Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial.

Smith SC, Heal CF, Buttner PG - BMJ Open (2014)

Bottom Line: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb.Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064).This represented an absolute reduction of 23.21% (95% CI -0.39% to 46.82%), relative reduction of 65.00% (95% CI -12.70% to 89.13%) and number-needed-to-treat of 4.3.

View Article: PubMed Central - PubMed

Affiliation: The Townsville Hospital, Townsville, Queensland, Australia.

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Trial profile (ROS, removal of sutures).
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BMJOPEN2014005270F1: Trial profile (ROS, removal of sutures).

Mentions: Of a total of 78 excisions from the lower limb conducted during the collection period, 26 cases were excluded from the study (figure 1). Fifty-two cases were subsequently randomised and underwent skin lesion excision. Three participants forgot to take the trial medication prior to their excision, and one participant treated his wound with a topical antiseptic. Follow-up was completed in all 52 (100%) participants randomised. Six doctors across the two practices were involved, each recruiting between 3 and 18 patients.


Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial.

Smith SC, Heal CF, Buttner PG - BMJ Open (2014)

Trial profile (ROS, removal of sutures).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120377&req=5

BMJOPEN2014005270F1: Trial profile (ROS, removal of sutures).
Mentions: Of a total of 78 excisions from the lower limb conducted during the collection period, 26 cases were excluded from the study (figure 1). Fifty-two cases were subsequently randomised and underwent skin lesion excision. Three participants forgot to take the trial medication prior to their excision, and one participant treated his wound with a topical antiseptic. Follow-up was completed in all 52 (100%) participants randomised. Six doctors across the two practices were involved, each recruiting between 3 and 18 patients.

Bottom Line: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb.Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064).This represented an absolute reduction of 23.21% (95% CI -0.39% to 46.82%), relative reduction of 65.00% (95% CI -12.70% to 89.13%) and number-needed-to-treat of 4.3.

View Article: PubMed Central - PubMed

Affiliation: The Townsville Hospital, Townsville, Queensland, Australia.

Show MeSH
Related in: MedlinePlus