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Depth and area of retinal nerve fiber layer damage and visual field correlation analysis.

Suh W, Lee JM, Kee C - Korean J Ophthalmol (2014)

Bottom Line: Age, optic disc size, refraction, central corneal thickness and the presence of systemic disease were corrected for in order to exclude confounding factors.Many outliers were detected in the Lowess-plotted graphs.The thickness of the RNFL had a negative logarithmic correlation with the VF indices and was more relevant to the VF indices than the area of the RNFL defect, as measured by OCT.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Dongtan Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

ABSTRACT

Purpose: To evaluate the relationship between the structural damage as assessed by time-domain optical coherence tomography (OCT) and functional changes in glaucoma.

Methods: In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included in this study. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defect were determined using OCT scans. The relationships between the RNFL thickness or area of the defect and visual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearman correlation. The differences between these associations depending on the stage of VF damage were further analyzed. Age, optic disc size, refraction, central corneal thickness and the presence of systemic disease were corrected for in order to exclude confounding factors.

Results: A logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The area of the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnant RNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlation coefficient, 0.39, -0.47, respectively; p < 0.0001). Many outliers were detected in the Lowess-plotted graphs. Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationship with the VF indices (partial Spearman correlation coefficient, 0.46; 95% confidence interval, 0.34 to 0.57; p < 0.0001). In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviation was significantly greater than in other stages (partial Spearman correlation coefficient, -0.66; p = 0.02).

Conclusions: The thickness of the RNFL had a negative logarithmic correlation with the VF indices and was more relevant to the VF indices than the area of the RNFL defect, as measured by OCT.

No MeSH data available.


Related in: MedlinePlus

Correlation between retinal nerve fiber layer (RNFL) thickness and visual field (VF) index. In the correlation analysis with mean deviation (MD), the slope of RNFL thickness changed rapidly around the numerical value of 81 (A). A logarithmic scale of the RNFL thickness showed a negative linear relationship with the MD index of the VF (B). When the residual of the RNFL thickness was plotted, the normality was not satisfied and many outliers were present (C,D). The slope of the pattern of standard deviation (PSD) line changed rapidly at the point when the RNFL thickness was 84.25 (E). The Lowess plot of the RNFL thickness and PSD suggested a logarithmic relationship (F).
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Figure 1: Correlation between retinal nerve fiber layer (RNFL) thickness and visual field (VF) index. In the correlation analysis with mean deviation (MD), the slope of RNFL thickness changed rapidly around the numerical value of 81 (A). A logarithmic scale of the RNFL thickness showed a negative linear relationship with the MD index of the VF (B). When the residual of the RNFL thickness was plotted, the normality was not satisfied and many outliers were present (C,D). The slope of the pattern of standard deviation (PSD) line changed rapidly at the point when the RNFL thickness was 84.25 (E). The Lowess plot of the RNFL thickness and PSD suggested a logarithmic relationship (F).

Mentions: In the correlation analysis with MD, the slope of the RNFL thickness rapidly changed around the numerical value of 81 (Fig. 1A). A logarithmic scale of the RNFL thickness showed a negative linear relationship with the MD index of VF (Fig. 1B). When the residual RNFL thickness was plotted, normality was not satisfied and many outliers were found (Fig. 1C and 1D). RNFL thickness and MD were moderately correlated (partial Spearman correlation coefficient, 0.52015; 95% CI, 0.4048 to 0.6175; p < 0.0001). The correlation between RNFL thickness and MD was not significantly different depending on the stage of the VF defect (adjusted p-value of early vs. moderate, early vs. severe and moderate vs. severe stages = 1, 1 and 0.82, respectively).


Depth and area of retinal nerve fiber layer damage and visual field correlation analysis.

Suh W, Lee JM, Kee C - Korean J Ophthalmol (2014)

Correlation between retinal nerve fiber layer (RNFL) thickness and visual field (VF) index. In the correlation analysis with mean deviation (MD), the slope of RNFL thickness changed rapidly around the numerical value of 81 (A). A logarithmic scale of the RNFL thickness showed a negative linear relationship with the MD index of the VF (B). When the residual of the RNFL thickness was plotted, the normality was not satisfied and many outliers were present (C,D). The slope of the pattern of standard deviation (PSD) line changed rapidly at the point when the RNFL thickness was 84.25 (E). The Lowess plot of the RNFL thickness and PSD suggested a logarithmic relationship (F).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120353&req=5

Figure 1: Correlation between retinal nerve fiber layer (RNFL) thickness and visual field (VF) index. In the correlation analysis with mean deviation (MD), the slope of RNFL thickness changed rapidly around the numerical value of 81 (A). A logarithmic scale of the RNFL thickness showed a negative linear relationship with the MD index of the VF (B). When the residual of the RNFL thickness was plotted, the normality was not satisfied and many outliers were present (C,D). The slope of the pattern of standard deviation (PSD) line changed rapidly at the point when the RNFL thickness was 84.25 (E). The Lowess plot of the RNFL thickness and PSD suggested a logarithmic relationship (F).
Mentions: In the correlation analysis with MD, the slope of the RNFL thickness rapidly changed around the numerical value of 81 (Fig. 1A). A logarithmic scale of the RNFL thickness showed a negative linear relationship with the MD index of VF (Fig. 1B). When the residual RNFL thickness was plotted, normality was not satisfied and many outliers were found (Fig. 1C and 1D). RNFL thickness and MD were moderately correlated (partial Spearman correlation coefficient, 0.52015; 95% CI, 0.4048 to 0.6175; p < 0.0001). The correlation between RNFL thickness and MD was not significantly different depending on the stage of the VF defect (adjusted p-value of early vs. moderate, early vs. severe and moderate vs. severe stages = 1, 1 and 0.82, respectively).

Bottom Line: Age, optic disc size, refraction, central corneal thickness and the presence of systemic disease were corrected for in order to exclude confounding factors.Many outliers were detected in the Lowess-plotted graphs.The thickness of the RNFL had a negative logarithmic correlation with the VF indices and was more relevant to the VF indices than the area of the RNFL defect, as measured by OCT.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Dongtan Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

ABSTRACT

Purpose: To evaluate the relationship between the structural damage as assessed by time-domain optical coherence tomography (OCT) and functional changes in glaucoma.

Methods: In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included in this study. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defect were determined using OCT scans. The relationships between the RNFL thickness or area of the defect and visual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearman correlation. The differences between these associations depending on the stage of VF damage were further analyzed. Age, optic disc size, refraction, central corneal thickness and the presence of systemic disease were corrected for in order to exclude confounding factors.

Results: A logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The area of the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnant RNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlation coefficient, 0.39, -0.47, respectively; p < 0.0001). Many outliers were detected in the Lowess-plotted graphs. Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationship with the VF indices (partial Spearman correlation coefficient, 0.46; 95% confidence interval, 0.34 to 0.57; p < 0.0001). In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviation was significantly greater than in other stages (partial Spearman correlation coefficient, -0.66; p = 0.02).

Conclusions: The thickness of the RNFL had a negative logarithmic correlation with the VF indices and was more relevant to the VF indices than the area of the RNFL defect, as measured by OCT.

No MeSH data available.


Related in: MedlinePlus