Limits...
Efficacy of intravitreal anti-vascular endothelial growth factor or steroid injection in diabetic macular edema according to fluid turbidity in optical coherence tomography.

Lee K, Chung H, Park Y, Sohn J - Korean J Ophthalmol (2014)

Bottom Line: Visual acuity and central macular thickness improved after injections in both groups.In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients.

View Article: PubMed Central - PubMed

Affiliation: HanGil Eye Hospital, Incheon, Korea.

ABSTRACT

Purpose: To determine if short term effects of intravitreal anti-vascular endothelial growth factor or steroid injection are correlated with fluid turbidity, as detected by spectral domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME) patients.

Methods: A total of 583 medical records were reviewed and 104 cases were enrolled. Sixty eyes received a single intravitreal bevacizumab injection (IVB) on the first attack of DME and 44 eyes received triamcinolone acetonide treatment (IVTA). Intraretinal fluid turbidity in DME patients was estimated with initial intravitreal SD-OCT and analyzed with color histograms from a Photoshop program. Central macular thickness and visual acuity using a logarithm from the minimum angle of resolution chart, were assessed at the initial period and 2 months after injections.

Results: Visual acuity and central macular thickness improved after injections in both groups. In the IVB group, visual acuity and central macular thickness changed less as the intraretinal fluid became more turbid. In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.

Conclusions: IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients. Further, fluid turbidity, which was detected by SD-OCT may be one of the indexes that highlight the influence of the steroid-dependent pathogenetic mechanism.

No MeSH data available.


Related in: MedlinePlus

Correlation between intraretinal fluid turbidity and the change of both the mean best-corrected visual acuity (A) and central macular thickness (CMT) (B) in the intravitreal bevacizumab injection (IVB) group. Change of the best mean corrected visual acuity is defined as the subtraction between initial best-corrected visual acuity and the 2 month postoperative best-corrected visual acuity. Further the change of CMT is defined as [(CMTat baseline - CMTat postoperative 2 months) / CMTat baseline] × 100. As the intraretinal fluid turbidity increased in the IVB group, the best-corrected visual acuity (A) and CMT (B) remained unchanged compared to initial measurements.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4120350&req=5

Figure 4: Correlation between intraretinal fluid turbidity and the change of both the mean best-corrected visual acuity (A) and central macular thickness (CMT) (B) in the intravitreal bevacizumab injection (IVB) group. Change of the best mean corrected visual acuity is defined as the subtraction between initial best-corrected visual acuity and the 2 month postoperative best-corrected visual acuity. Further the change of CMT is defined as [(CMTat baseline - CMTat postoperative 2 months) / CMTat baseline] × 100. As the intraretinal fluid turbidity increased in the IVB group, the best-corrected visual acuity (A) and CMT (B) remained unchanged compared to initial measurements.

Mentions: In the IVB group, as intraretinal fluid turbidity increased, the mean BCVA and CMT underwent less changes and nearly remained unchanged (Fig. 4). Also, there were no statistically significant correlations between the intraretinal fluid turbidity and change of both the mean BCVA and CMT (Table 2).


Efficacy of intravitreal anti-vascular endothelial growth factor or steroid injection in diabetic macular edema according to fluid turbidity in optical coherence tomography.

Lee K, Chung H, Park Y, Sohn J - Korean J Ophthalmol (2014)

Correlation between intraretinal fluid turbidity and the change of both the mean best-corrected visual acuity (A) and central macular thickness (CMT) (B) in the intravitreal bevacizumab injection (IVB) group. Change of the best mean corrected visual acuity is defined as the subtraction between initial best-corrected visual acuity and the 2 month postoperative best-corrected visual acuity. Further the change of CMT is defined as [(CMTat baseline - CMTat postoperative 2 months) / CMTat baseline] × 100. As the intraretinal fluid turbidity increased in the IVB group, the best-corrected visual acuity (A) and CMT (B) remained unchanged compared to initial measurements.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120350&req=5

Figure 4: Correlation between intraretinal fluid turbidity and the change of both the mean best-corrected visual acuity (A) and central macular thickness (CMT) (B) in the intravitreal bevacizumab injection (IVB) group. Change of the best mean corrected visual acuity is defined as the subtraction between initial best-corrected visual acuity and the 2 month postoperative best-corrected visual acuity. Further the change of CMT is defined as [(CMTat baseline - CMTat postoperative 2 months) / CMTat baseline] × 100. As the intraretinal fluid turbidity increased in the IVB group, the best-corrected visual acuity (A) and CMT (B) remained unchanged compared to initial measurements.
Mentions: In the IVB group, as intraretinal fluid turbidity increased, the mean BCVA and CMT underwent less changes and nearly remained unchanged (Fig. 4). Also, there were no statistically significant correlations between the intraretinal fluid turbidity and change of both the mean BCVA and CMT (Table 2).

Bottom Line: Visual acuity and central macular thickness improved after injections in both groups.In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients.

View Article: PubMed Central - PubMed

Affiliation: HanGil Eye Hospital, Incheon, Korea.

ABSTRACT

Purpose: To determine if short term effects of intravitreal anti-vascular endothelial growth factor or steroid injection are correlated with fluid turbidity, as detected by spectral domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME) patients.

Methods: A total of 583 medical records were reviewed and 104 cases were enrolled. Sixty eyes received a single intravitreal bevacizumab injection (IVB) on the first attack of DME and 44 eyes received triamcinolone acetonide treatment (IVTA). Intraretinal fluid turbidity in DME patients was estimated with initial intravitreal SD-OCT and analyzed with color histograms from a Photoshop program. Central macular thickness and visual acuity using a logarithm from the minimum angle of resolution chart, were assessed at the initial period and 2 months after injections.

Results: Visual acuity and central macular thickness improved after injections in both groups. In the IVB group, visual acuity and central macular thickness changed less as the intraretinal fluid became more turbid. In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.

Conclusions: IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients. Further, fluid turbidity, which was detected by SD-OCT may be one of the indexes that highlight the influence of the steroid-dependent pathogenetic mechanism.

No MeSH data available.


Related in: MedlinePlus