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Efficacy of intravitreal anti-vascular endothelial growth factor or steroid injection in diabetic macular edema according to fluid turbidity in optical coherence tomography.

Lee K, Chung H, Park Y, Sohn J - Korean J Ophthalmol (2014)

Bottom Line: Visual acuity and central macular thickness improved after injections in both groups.In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients.

View Article: PubMed Central - PubMed

Affiliation: HanGil Eye Hospital, Incheon, Korea.

ABSTRACT

Purpose: To determine if short term effects of intravitreal anti-vascular endothelial growth factor or steroid injection are correlated with fluid turbidity, as detected by spectral domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME) patients.

Methods: A total of 583 medical records were reviewed and 104 cases were enrolled. Sixty eyes received a single intravitreal bevacizumab injection (IVB) on the first attack of DME and 44 eyes received triamcinolone acetonide treatment (IVTA). Intraretinal fluid turbidity in DME patients was estimated with initial intravitreal SD-OCT and analyzed with color histograms from a Photoshop program. Central macular thickness and visual acuity using a logarithm from the minimum angle of resolution chart, were assessed at the initial period and 2 months after injections.

Results: Visual acuity and central macular thickness improved after injections in both groups. In the IVB group, visual acuity and central macular thickness changed less as the intraretinal fluid became more turbid. In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.

Conclusions: IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients. Further, fluid turbidity, which was detected by SD-OCT may be one of the indexes that highlight the influence of the steroid-dependent pathogenetic mechanism.

No MeSH data available.


Related in: MedlinePlus

The measurement of intraretinal fluid turbidity. Fluid turbidity was measured using a Photoshop program. Every cystoid area in intraretinal layer was dragged using the Photoshop dragging tool and a tablet pen. The color histogram of every dragged image was examined and the median value of each image was obtained.
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Figure 1: The measurement of intraretinal fluid turbidity. Fluid turbidity was measured using a Photoshop program. Every cystoid area in intraretinal layer was dragged using the Photoshop dragging tool and a tablet pen. The color histogram of every dragged image was examined and the median value of each image was obtained.

Mentions: Fluid turbidity was measured using Photoshop (Adobe Systems, San Jose, CA, USA). Every cystoid area in the intraretinal layer of one raster image frame from the SD-OCT was dragged using the Photoshop dragging tool (Fig. 1). The color histogram of every dragged image was examined. Thereafter, we obtained the median value of each image and calculated the median value of each dragged area in that frame. Then, we calculated the average of the total median value of each frame, which was defined as the fluid turbidity.


Efficacy of intravitreal anti-vascular endothelial growth factor or steroid injection in diabetic macular edema according to fluid turbidity in optical coherence tomography.

Lee K, Chung H, Park Y, Sohn J - Korean J Ophthalmol (2014)

The measurement of intraretinal fluid turbidity. Fluid turbidity was measured using a Photoshop program. Every cystoid area in intraretinal layer was dragged using the Photoshop dragging tool and a tablet pen. The color histogram of every dragged image was examined and the median value of each image was obtained.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120350&req=5

Figure 1: The measurement of intraretinal fluid turbidity. Fluid turbidity was measured using a Photoshop program. Every cystoid area in intraretinal layer was dragged using the Photoshop dragging tool and a tablet pen. The color histogram of every dragged image was examined and the median value of each image was obtained.
Mentions: Fluid turbidity was measured using Photoshop (Adobe Systems, San Jose, CA, USA). Every cystoid area in the intraretinal layer of one raster image frame from the SD-OCT was dragged using the Photoshop dragging tool (Fig. 1). The color histogram of every dragged image was examined. Thereafter, we obtained the median value of each image and calculated the median value of each dragged area in that frame. Then, we calculated the average of the total median value of each frame, which was defined as the fluid turbidity.

Bottom Line: Visual acuity and central macular thickness improved after injections in both groups.In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients.

View Article: PubMed Central - PubMed

Affiliation: HanGil Eye Hospital, Incheon, Korea.

ABSTRACT

Purpose: To determine if short term effects of intravitreal anti-vascular endothelial growth factor or steroid injection are correlated with fluid turbidity, as detected by spectral domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME) patients.

Methods: A total of 583 medical records were reviewed and 104 cases were enrolled. Sixty eyes received a single intravitreal bevacizumab injection (IVB) on the first attack of DME and 44 eyes received triamcinolone acetonide treatment (IVTA). Intraretinal fluid turbidity in DME patients was estimated with initial intravitreal SD-OCT and analyzed with color histograms from a Photoshop program. Central macular thickness and visual acuity using a logarithm from the minimum angle of resolution chart, were assessed at the initial period and 2 months after injections.

Results: Visual acuity and central macular thickness improved after injections in both groups. In the IVB group, visual acuity and central macular thickness changed less as the intraretinal fluid became more turbid. In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.

Conclusions: IVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients. Further, fluid turbidity, which was detected by SD-OCT may be one of the indexes that highlight the influence of the steroid-dependent pathogenetic mechanism.

No MeSH data available.


Related in: MedlinePlus