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Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review.

Peinemann F, Labeit AM - BMJ Open (2014)

Bottom Line: We excluded studies on participants with secondary aplastic anaemia.PRIMARY AND SECONDARY OUTCOME MEASURES PLANNED AND FINALLY MEASURED: The primary outcome was overall mortality.Secondary outcomes were treatment-related mortality, graft failure, graft-versus-host disease, no response to immunosuppressive therapy, relapse after initial successful treatment, secondary clonal disease or malignancies, health-related quality of life and performance scores.

View Article: PubMed Central - PubMed

Affiliation: Children's Hospital, University of Cologne, Cologne, Germany.

No MeSH data available.


Related in: MedlinePlus

Mortality in the donor group (MSD-HSCT) versus the no donor group (IST); effect: HR; random-effects model. SE calculated from data presented in the Kaplan-Meier graph of the article (MSD-HSCT, first-line allogeneic haematopoietic stem cell transplantation of bone marrow of HLA-matched sibling donors; log, logarithm; IST, first-line immunosuppressive therapy; IV, inverse variance).
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BMJOPEN2014005039F2: Mortality in the donor group (MSD-HSCT) versus the no donor group (IST); effect: HR; random-effects model. SE calculated from data presented in the Kaplan-Meier graph of the article (MSD-HSCT, first-line allogeneic haematopoietic stem cell transplantation of bone marrow of HLA-matched sibling donors; log, logarithm; IST, first-line immunosuppressive therapy; IV, inverse variance).

Mentions: The pooled HR estimate for overall mortality was 0.95 with a 95% CI of 0.43 to 2.12 (p=0.90; figure 2). According to the meta-analysis based on data from all three included studies, overall mortality was not statistically significantly different between MSD-HSCT and IST. Overall survival ranged from 47% to 84% in the MSD-HSCT group and from 45% to 87% in the IST group (table 3). The results for the secondary outcomes including treatment-related mortality after MSD-HSCT, graft failure after MSD-HSCT, graft-versus-host-disease (GVHD) after MSD-HSCT, no response to IST and relapse after IST are shown in table 4. With respect to secondary clonal disease or malignancies, Bayever et al20 reported one patient who developed T-cell lymphoma after MSD-HSCT and Führer et al22 reported four patients who developed acute myelogenous leukaemia after IST. Health-related quality of life questionnaires were not used in any of the included studies. Bayever et al20 reported that almost all evaluable patients in the MSD-HSCT group (92%) and less than half of the patients in the IST group had a Karnofsky Performance Status of higher than 70%.


Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review.

Peinemann F, Labeit AM - BMJ Open (2014)

Mortality in the donor group (MSD-HSCT) versus the no donor group (IST); effect: HR; random-effects model. SE calculated from data presented in the Kaplan-Meier graph of the article (MSD-HSCT, first-line allogeneic haematopoietic stem cell transplantation of bone marrow of HLA-matched sibling donors; log, logarithm; IST, first-line immunosuppressive therapy; IV, inverse variance).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120307&req=5

BMJOPEN2014005039F2: Mortality in the donor group (MSD-HSCT) versus the no donor group (IST); effect: HR; random-effects model. SE calculated from data presented in the Kaplan-Meier graph of the article (MSD-HSCT, first-line allogeneic haematopoietic stem cell transplantation of bone marrow of HLA-matched sibling donors; log, logarithm; IST, first-line immunosuppressive therapy; IV, inverse variance).
Mentions: The pooled HR estimate for overall mortality was 0.95 with a 95% CI of 0.43 to 2.12 (p=0.90; figure 2). According to the meta-analysis based on data from all three included studies, overall mortality was not statistically significantly different between MSD-HSCT and IST. Overall survival ranged from 47% to 84% in the MSD-HSCT group and from 45% to 87% in the IST group (table 3). The results for the secondary outcomes including treatment-related mortality after MSD-HSCT, graft failure after MSD-HSCT, graft-versus-host-disease (GVHD) after MSD-HSCT, no response to IST and relapse after IST are shown in table 4. With respect to secondary clonal disease or malignancies, Bayever et al20 reported one patient who developed T-cell lymphoma after MSD-HSCT and Führer et al22 reported four patients who developed acute myelogenous leukaemia after IST. Health-related quality of life questionnaires were not used in any of the included studies. Bayever et al20 reported that almost all evaluable patients in the MSD-HSCT group (92%) and less than half of the patients in the IST group had a Karnofsky Performance Status of higher than 70%.

Bottom Line: We excluded studies on participants with secondary aplastic anaemia.PRIMARY AND SECONDARY OUTCOME MEASURES PLANNED AND FINALLY MEASURED: The primary outcome was overall mortality.Secondary outcomes were treatment-related mortality, graft failure, graft-versus-host disease, no response to immunosuppressive therapy, relapse after initial successful treatment, secondary clonal disease or malignancies, health-related quality of life and performance scores.

View Article: PubMed Central - PubMed

Affiliation: Children's Hospital, University of Cologne, Cologne, Germany.

No MeSH data available.


Related in: MedlinePlus