Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction.
Bottom Line: Radical oxygen species level was also reduced by H(2) treatment.Finally, we found that H(2) could regulate the polarization of CD4+ T cells and the level of related cytokines.This study suggests H(2) as an effective radioprotective agent on immune system by scavenging reactive oxygen species.
Affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.Show MeSH
Related in: MedlinePlus
Mentions: The splenic morphology was characterized by using the following subjective descriptors: control, diminished, depleted when compared with normal group (Table 2). Cellularity of white pulp decreased significantly after exposure to 5 Gy irradiation. Both width and density of the layer of lymphocytes appeared to decrease obviously. Cellularity of red pulp was obviously reduced and accompanied by tissue congestion. And the resulting morphology was described as depleted (Fig. 2B). Compared with Figure 2B, the reduction in cellularity of white pulp and red pulp was less remarkable and the morphology was characterized as diminished (Fig. 2C). Fourteen days post exposure, cellularity of both white pulp and red pulp in radiation group and H2 group recovered, while the structure in radiation group was much disorganized and the density of cells were lower compared with the H2 group (Fig. 2D and E).
Affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.