Ischaemia-related cell damage in extracorporeal preserved tissue - new findings with a novel perfusion model.
Bottom Line: Expression of Caspase-3 after 60 min. was reduced in all groups compared to the control group.Oxygenation leads to higher oxygen levels at the venous branch compared to groups without oxygenation.Complete depletion of oxygen at the venous branch can be prevented by oxygenation of the perfusate with ambient air.
Affiliation: Department of Plastic and Hand Surgery, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.Show MeSH
Related in: MedlinePlus
Mentions: As shown in Figure 5, singular flush with the cardioplegic solution (group III) prevents a statistically significant increase in the expression of Caspase-3 during the different time-points 15, 30 and 60 min. compared to the baseline. Similar results have been found in the group that was treated with perfusion and oxygenation with the cardioplegic solution (group V).
Affiliation: Department of Plastic and Hand Surgery, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.