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Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats.

Zhao B, Liao Z, Chen S, Yuan Z, Yilin C, Lee KK, Qi X, Shen X, Zheng X, Quinn T, Cai D - J. Cell. Mol. Med. (2014)

Bottom Line: The cellular mechanism behind this beneficial effect on MI was partially attributed to increased cardiac angiogenesis, improved reconstruction of the CT network and decreased myocardial fibrosis.These combined effects decreased the infarct size, improved the reconstruction of the LV and enhanced myocardial function in MI.Our findings suggest that CTs could be considered as a potential cell source for therapeutic use to improve cardiac repair and function following MI, used either alone or in tandem with stem cells.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China; Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China; International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China; Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China.

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Transplantation of cardiac telocytes improved myocardial function in myocardial infarction (MI). Myocardial function of MI hearts was analysed by echocardiography 14-week post-LAD ligation showing (A) the ejection fraction of the CT-treated group was significantly higher than the PBS-treated group (P < 0.01). (B) the final diastolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.05). (C) the final systolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.01). N = 4–5 for each group. *P < 0.05, CT-treated group versusPBS-treated group; **P < 0.01, CT-treated group versusPBS-treated group.
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fig02: Transplantation of cardiac telocytes improved myocardial function in myocardial infarction (MI). Myocardial function of MI hearts was analysed by echocardiography 14-week post-LAD ligation showing (A) the ejection fraction of the CT-treated group was significantly higher than the PBS-treated group (P < 0.01). (B) the final diastolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.05). (C) the final systolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.01). N = 4–5 for each group. *P < 0.05, CT-treated group versusPBS-treated group; **P < 0.01, CT-treated group versusPBS-treated group.

Mentions: The myocardial function was evaluated by echocardiography, 14 weeks after LAD ligation and CT transplantation. The results of echocardiography for the MI hearts revealed that the EF of the CT-treated group was significantly higher than the PBS-treated group (P < 0.01). The EF of the CT-treated group was higher than that of the c-kit− cell-treated group, however, the difference was not statistically significant (P > 0.05; Fig. 2A). The final diastolic diameters of the CT-treated group were lower than those of the c-kit− cell-treated group and PBS-treated group (P < 0.05 versus PBS-treated group; Fig. 2B). In addition, the final systolic diameters of the CT-treated group were lower than those of the c-kit− cell-treated group and PBS-treated group (P < 0.01 versus PBS-treated group; Fig. 2C).


Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats.

Zhao B, Liao Z, Chen S, Yuan Z, Yilin C, Lee KK, Qi X, Shen X, Zheng X, Quinn T, Cai D - J. Cell. Mol. Med. (2014)

Transplantation of cardiac telocytes improved myocardial function in myocardial infarction (MI). Myocardial function of MI hearts was analysed by echocardiography 14-week post-LAD ligation showing (A) the ejection fraction of the CT-treated group was significantly higher than the PBS-treated group (P < 0.01). (B) the final diastolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.05). (C) the final systolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.01). N = 4–5 for each group. *P < 0.05, CT-treated group versusPBS-treated group; **P < 0.01, CT-treated group versusPBS-treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4119384&req=5

fig02: Transplantation of cardiac telocytes improved myocardial function in myocardial infarction (MI). Myocardial function of MI hearts was analysed by echocardiography 14-week post-LAD ligation showing (A) the ejection fraction of the CT-treated group was significantly higher than the PBS-treated group (P < 0.01). (B) the final diastolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.05). (C) the final systolic diameters of the CT-treated group was significantly lower than the PBS-treated group (P < 0.01). N = 4–5 for each group. *P < 0.05, CT-treated group versusPBS-treated group; **P < 0.01, CT-treated group versusPBS-treated group.
Mentions: The myocardial function was evaluated by echocardiography, 14 weeks after LAD ligation and CT transplantation. The results of echocardiography for the MI hearts revealed that the EF of the CT-treated group was significantly higher than the PBS-treated group (P < 0.01). The EF of the CT-treated group was higher than that of the c-kit− cell-treated group, however, the difference was not statistically significant (P > 0.05; Fig. 2A). The final diastolic diameters of the CT-treated group were lower than those of the c-kit− cell-treated group and PBS-treated group (P < 0.05 versus PBS-treated group; Fig. 2B). In addition, the final systolic diameters of the CT-treated group were lower than those of the c-kit− cell-treated group and PBS-treated group (P < 0.01 versus PBS-treated group; Fig. 2C).

Bottom Line: The cellular mechanism behind this beneficial effect on MI was partially attributed to increased cardiac angiogenesis, improved reconstruction of the CT network and decreased myocardial fibrosis.These combined effects decreased the infarct size, improved the reconstruction of the LV and enhanced myocardial function in MI.Our findings suggest that CTs could be considered as a potential cell source for therapeutic use to improve cardiac repair and function following MI, used either alone or in tandem with stem cells.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China; Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China; International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China; Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, China.

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Related in: MedlinePlus