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Intraosseous malignant peripheral nerve sheath tumor of maxilla: A case report with review of the literature.

Tamgadge S, Modak N, Tamgadge AP, Bhalerao S - Dent Res J (Isfahan) (2014)

Bottom Line: Malignant peripheral nerve sheath tumor (MPNST), the principle malignancy of peripheral nerve origin, though rare in the general population, occurs with excessive frequency among patients with neurofibromatosis.This tumor always arises in soft-tissues, usually found in the lower extremities and only 10-12% of all lesions occur in the head and neck region, which makes it a rare entity.This article discusses a case report of MPNST of the left maxilla without a history of benign nerve tissue tumor and the diagnostic difficulties associated with MPNST.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, Padmashree Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, Maharashtra, India.

ABSTRACT
Malignant peripheral nerve sheath tumor (MPNST), the principle malignancy of peripheral nerve origin, though rare in the general population, occurs with excessive frequency among patients with neurofibromatosis. This tumor always arises in soft-tissues, usually found in the lower extremities and only 10-12% of all lesions occur in the head and neck region, which makes it a rare entity. The primary intraosseous MPNST is rare and has been reported most frequently in the mandible. This article discusses a case report of MPNST of the left maxilla without a history of benign nerve tissue tumor and the diagnostic difficulties associated with MPNST.

No MeSH data available.


Related in: MedlinePlus

Herringbone pattern of malignant spindle shape cells (H and E, original magnification ×10) (cells in a malignant peripheral nerve sheath tumor having irregular, buckled shape with wavy nuclei under higher magnification [inset])
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Figure 3: Herringbone pattern of malignant spindle shape cells (H and E, original magnification ×10) (cells in a malignant peripheral nerve sheath tumor having irregular, buckled shape with wavy nuclei under higher magnification [inset])

Mentions: Microscopic examination of H and E stained section showed highly cellular lesional tissue consisting of numerous malignant spindle shape cells with wavy nuclei, showing fascicles, whorls and a palisaded arrangement. At many places herringbone pattern [Figure 3] was also evident. These cells showed hyperchromatic nuclei with mitotic figures [Figure 4] with xanthomatous change around irregularly arranged neoplastic cells [Figure 5]. Few areas of necrosis were observed [Figure 6] and transverse sections of nerve bundles were also evident with perineural invasion [Figure 7]. Few areas showed perimucsular invasion [Figure 8] and at places the tumor appear to herniated into the lumen of vessels [Figure 9]. The histopathological findings were suggestive of MPNST. Immunohistochemical stain helped to confirm the diagnosis as the mesenchymal component stained intensely and focally with S-100 [Figure 10]. Correlating the radiological, histopathological and immunohistochemical investigation, a final diagnosis of MPNST was given.


Intraosseous malignant peripheral nerve sheath tumor of maxilla: A case report with review of the literature.

Tamgadge S, Modak N, Tamgadge AP, Bhalerao S - Dent Res J (Isfahan) (2014)

Herringbone pattern of malignant spindle shape cells (H and E, original magnification ×10) (cells in a malignant peripheral nerve sheath tumor having irregular, buckled shape with wavy nuclei under higher magnification [inset])
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4119377&req=5

Figure 3: Herringbone pattern of malignant spindle shape cells (H and E, original magnification ×10) (cells in a malignant peripheral nerve sheath tumor having irregular, buckled shape with wavy nuclei under higher magnification [inset])
Mentions: Microscopic examination of H and E stained section showed highly cellular lesional tissue consisting of numerous malignant spindle shape cells with wavy nuclei, showing fascicles, whorls and a palisaded arrangement. At many places herringbone pattern [Figure 3] was also evident. These cells showed hyperchromatic nuclei with mitotic figures [Figure 4] with xanthomatous change around irregularly arranged neoplastic cells [Figure 5]. Few areas of necrosis were observed [Figure 6] and transverse sections of nerve bundles were also evident with perineural invasion [Figure 7]. Few areas showed perimucsular invasion [Figure 8] and at places the tumor appear to herniated into the lumen of vessels [Figure 9]. The histopathological findings were suggestive of MPNST. Immunohistochemical stain helped to confirm the diagnosis as the mesenchymal component stained intensely and focally with S-100 [Figure 10]. Correlating the radiological, histopathological and immunohistochemical investigation, a final diagnosis of MPNST was given.

Bottom Line: Malignant peripheral nerve sheath tumor (MPNST), the principle malignancy of peripheral nerve origin, though rare in the general population, occurs with excessive frequency among patients with neurofibromatosis.This tumor always arises in soft-tissues, usually found in the lower extremities and only 10-12% of all lesions occur in the head and neck region, which makes it a rare entity.This article discusses a case report of MPNST of the left maxilla without a history of benign nerve tissue tumor and the diagnostic difficulties associated with MPNST.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, Padmashree Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, Maharashtra, India.

ABSTRACT
Malignant peripheral nerve sheath tumor (MPNST), the principle malignancy of peripheral nerve origin, though rare in the general population, occurs with excessive frequency among patients with neurofibromatosis. This tumor always arises in soft-tissues, usually found in the lower extremities and only 10-12% of all lesions occur in the head and neck region, which makes it a rare entity. The primary intraosseous MPNST is rare and has been reported most frequently in the mandible. This article discusses a case report of MPNST of the left maxilla without a history of benign nerve tissue tumor and the diagnostic difficulties associated with MPNST.

No MeSH data available.


Related in: MedlinePlus