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Prevalence of chronic kidney disease among adults in a rural community in South India: Results from the kidney disease screening (KIDS) project.

Anupama YJ, Uma G - Indian J Nephrol (2014)

Bottom Line: The prevalence of CKD was 16.54% by the CG-BSA method.There was a statistically significant relationship of CKD with gender, advancing age, abdominal obesity, smoking, presence of diabetes and hypertension.The prevalence of CKD is higher compared to the previous studies from rural India and is comparable to that in the studies from the urban Indian populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Nanjappa Hospital, Shimoga, Karnataka, India.

ABSTRACT
Prevalence of chronic kidney disease (CKD) appears to be increasing in India. A few studies have studied the prevalence of CKD in urban populations, but there is a paucity of such studies in the rural populations. This project was undertaken to study the prevalence of CKD among adults in a rural population near Shimoga, Karnataka and to study the risk factor profile. Door-to-door screening of 2091 people aged 18 and above was carried out. Demographic and anthropometric data were obtained, urine was analyzed for protein by dipstick and serum creatinine was measured in all participants. Glomerular filtration rate was estimated (eGFR) using the 4-variable modification of diet in renal disease (MDRD) equation and Cockcroft-Gault equation corrected to the body surface area (CG-BSA). The total number of subjects studied was 2091. Mean age was 39.88 ± 15.87 years. 45.57% were males. The prevalence of proteinuria was 2.8%. CKD was seen in 131 (6.3%) subjects when GFR was estimated by MDRD equation. The prevalence of CKD was 16.54% by the CG-BSA method. There was a statistically significant relationship of CKD with gender, advancing age, abdominal obesity, smoking, presence of diabetes and hypertension. The prevalence of CKD is higher compared to the previous studies from rural India and is comparable to that in the studies from the urban Indian populations. The wide difference between the CKD prevalence between MDRD and CG-BSA equations suggests the need for a better measure of kidney function applicable to Indian population.

No MeSH data available.


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Relative distribution of proteinuric and non-proteinuric chronic kidney disease
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Figure 2: Relative distribution of proteinuric and non-proteinuric chronic kidney disease

Mentions: Subgroup analysis was done in the 131 subjects with CKD (MDRD eGFR < 60 ml/min/1.73 m2. 77 (58.7%) of these were males and 54 were females. Majority of CKD subjects were in the age group of 60-69 (32 subjects) [Table 3]. Mean age of the subjects with CKD was 52.73 ± 17.08 years. Nearly 60% were in nuclear families and only 12% had vegetarian food habits. About 40.48% were uneducated while 31.29% had primary education only. Nearly 80% were either unemployed or were laborers. More than 70% of these subjects were having normal BMI or were underweight. Only 14.5% were obese. However, nearly 30% of the subjects with CKD had abdominal obesity. Proteinuria was present in 60 (45.80%) of CKD subjects while it was absent in 71 (54.20%) of CKD subjects, which indicates that more than one-half of our CKD patients are non-proteinuric. Proteinuria alone without decreased GFR was seen in 40 (30.53%) of CKD subjects [Figure 2].


Prevalence of chronic kidney disease among adults in a rural community in South India: Results from the kidney disease screening (KIDS) project.

Anupama YJ, Uma G - Indian J Nephrol (2014)

Relative distribution of proteinuric and non-proteinuric chronic kidney disease
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4119333&req=5

Figure 2: Relative distribution of proteinuric and non-proteinuric chronic kidney disease
Mentions: Subgroup analysis was done in the 131 subjects with CKD (MDRD eGFR < 60 ml/min/1.73 m2. 77 (58.7%) of these were males and 54 were females. Majority of CKD subjects were in the age group of 60-69 (32 subjects) [Table 3]. Mean age of the subjects with CKD was 52.73 ± 17.08 years. Nearly 60% were in nuclear families and only 12% had vegetarian food habits. About 40.48% were uneducated while 31.29% had primary education only. Nearly 80% were either unemployed or were laborers. More than 70% of these subjects were having normal BMI or were underweight. Only 14.5% were obese. However, nearly 30% of the subjects with CKD had abdominal obesity. Proteinuria was present in 60 (45.80%) of CKD subjects while it was absent in 71 (54.20%) of CKD subjects, which indicates that more than one-half of our CKD patients are non-proteinuric. Proteinuria alone without decreased GFR was seen in 40 (30.53%) of CKD subjects [Figure 2].

Bottom Line: The prevalence of CKD was 16.54% by the CG-BSA method.There was a statistically significant relationship of CKD with gender, advancing age, abdominal obesity, smoking, presence of diabetes and hypertension.The prevalence of CKD is higher compared to the previous studies from rural India and is comparable to that in the studies from the urban Indian populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Nanjappa Hospital, Shimoga, Karnataka, India.

ABSTRACT
Prevalence of chronic kidney disease (CKD) appears to be increasing in India. A few studies have studied the prevalence of CKD in urban populations, but there is a paucity of such studies in the rural populations. This project was undertaken to study the prevalence of CKD among adults in a rural population near Shimoga, Karnataka and to study the risk factor profile. Door-to-door screening of 2091 people aged 18 and above was carried out. Demographic and anthropometric data were obtained, urine was analyzed for protein by dipstick and serum creatinine was measured in all participants. Glomerular filtration rate was estimated (eGFR) using the 4-variable modification of diet in renal disease (MDRD) equation and Cockcroft-Gault equation corrected to the body surface area (CG-BSA). The total number of subjects studied was 2091. Mean age was 39.88 ± 15.87 years. 45.57% were males. The prevalence of proteinuria was 2.8%. CKD was seen in 131 (6.3%) subjects when GFR was estimated by MDRD equation. The prevalence of CKD was 16.54% by the CG-BSA method. There was a statistically significant relationship of CKD with gender, advancing age, abdominal obesity, smoking, presence of diabetes and hypertension. The prevalence of CKD is higher compared to the previous studies from rural India and is comparable to that in the studies from the urban Indian populations. The wide difference between the CKD prevalence between MDRD and CG-BSA equations suggests the need for a better measure of kidney function applicable to Indian population.

No MeSH data available.


Related in: MedlinePlus