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Clinicopathological correlations in lupus nephritis; a single center experience.

Nasri H, Ahmadi A, Baradaran A, Momeni A, Nasri P, Mardani S, Rafieian-Kopaei M, Mubarak M - J Nephropathol (2014)

Bottom Line: A significant association of serum creatinine with 24-h proteinuria (p= 0.041) was seen.Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145 respectively).In conclusion, the results from our study on biopsy-proven cases of LN largely concur with the previously reported studies from Iran and other parts of the world.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Renal biopsies play an important role in the diagnosis, management and prognosis of patients with lupus nephritis (LN).

Objectives: To determine the correlation between the pathological features of LN and the demographic, clinical and laboratory parameters.

Patients and methods: This retrospective study was conducted from 2008 to 2014 on all consecutive cases of biopsy-proven LN at a nephropathology laboratory in Iran. The demographic, clinical and laboratory data were obtained from patients(') files and the biopsy findings from the original biopsy request forms.

Results: Of the 84 patients enrolled, 69 (82.2%) were females and 15 (17.8%) males. The mean age was 32.7±12 years. The mean serum creatinine was 1.5±0.94 mg/dl and the mean 24-h proteinuria, 1.6±1.9 grams. The majority of cases belonged to classes III and IV. The extracapillary proliferation was found in 42.86% of biopsies and endocapillary proliferation in 66.67% of biopsies. Patients of class IV-LN had a higher mean serum value of creatinine in comparison to class III-LN (2.19±1.09 versus 1.2±0.56 mg/dl; p= 0.0001). There was no significant difference of 24-h proteinuria between the two classes (p= 0.882). A significant association of serum creatinine with 24-h proteinuria (p= 0.041) was seen. Serum creatinine had significant positive correlation with activity percent (p< 0.001), and chronicity percent (p= 0.006), and also with proportion of glomeruli with crescents (p < 0.001). While there was a significant relationship of proteinuria with chronicity percent (p= 0.001), this association for activity percent was not significant (p= 0.094). Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145 respectively).

Conclusions: In conclusion, the results from our study on biopsy-proven cases of LN largely concur with the previously reported studies from Iran and other parts of the world.

No MeSH data available.


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Mentions: Regarding the activity and chronicity of glomerular lesions, in this study we found that 30.95% of patients in class III-LN had active (A) lesions, while 69.05% of lesions were chronic (C) or active/chronic (A/C). Likewise, 64.16% of patients in class IV-LN had active (A) lesions, whereas 35.84% of lesions were chronic (C) or active/chronic (A/C). Table 4 shows that 64±28 of class IV versus 30±23 of class III, had active glomerular lesions and this was statistically significant (p= 0.0001). Since, the most common classes of LN were class III and IV, we carried out correlation analysis for these classes of LN. There was no significant difference in the mean number of totally sclerotic glomeruli between class III and IV LN biopsies (p= 0.152). Patients of class IV-LN had a higher mean serum value of creatinine in comparison to class III- LN (2.19±1.09 versus 1.2±0.56 mg/dl; p= 0.0001). Additionally, there was no significant difference of 24-h urinary protein excretion between the two classes (p= 0.882). The mean serum creatinine was higher in male patients than in females, but was not statistically significant (1.62±1.2 versus 1.52±0.88 mg/dl; p= 0.709). The mean number of totally sclerosed glomeruli in male patients was more than in female patients (7.3±1.1 versus 1.65± 3; p= 0.001). In this study, a significant association of serum creatinine with the degree of 24-h proteinuria (p= 0.041) was seen. The association of serum creatinine with globally sclerotic glomeruli was not statistically significant (p= 0.115). Serum creatinine had significant positive correlation with activity percent (p< 0.001), and chronicity percent (p= 0.006) (Figures 1 and 2 ), and also with proportion of glomeruli with crescents (p< 0.001).While, there was a significant relationship of proteinuria with chronicity percent (p= 0.001), this association for activity percent was not significant (p= 0.094). Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145, respectively).


Clinicopathological correlations in lupus nephritis; a single center experience.

Nasri H, Ahmadi A, Baradaran A, Momeni A, Nasri P, Mardani S, Rafieian-Kopaei M, Mubarak M - J Nephropathol (2014)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4119327&req=5

Mentions: Regarding the activity and chronicity of glomerular lesions, in this study we found that 30.95% of patients in class III-LN had active (A) lesions, while 69.05% of lesions were chronic (C) or active/chronic (A/C). Likewise, 64.16% of patients in class IV-LN had active (A) lesions, whereas 35.84% of lesions were chronic (C) or active/chronic (A/C). Table 4 shows that 64±28 of class IV versus 30±23 of class III, had active glomerular lesions and this was statistically significant (p= 0.0001). Since, the most common classes of LN were class III and IV, we carried out correlation analysis for these classes of LN. There was no significant difference in the mean number of totally sclerotic glomeruli between class III and IV LN biopsies (p= 0.152). Patients of class IV-LN had a higher mean serum value of creatinine in comparison to class III- LN (2.19±1.09 versus 1.2±0.56 mg/dl; p= 0.0001). Additionally, there was no significant difference of 24-h urinary protein excretion between the two classes (p= 0.882). The mean serum creatinine was higher in male patients than in females, but was not statistically significant (1.62±1.2 versus 1.52±0.88 mg/dl; p= 0.709). The mean number of totally sclerosed glomeruli in male patients was more than in female patients (7.3±1.1 versus 1.65± 3; p= 0.001). In this study, a significant association of serum creatinine with the degree of 24-h proteinuria (p= 0.041) was seen. The association of serum creatinine with globally sclerotic glomeruli was not statistically significant (p= 0.115). Serum creatinine had significant positive correlation with activity percent (p< 0.001), and chronicity percent (p= 0.006) (Figures 1 and 2 ), and also with proportion of glomeruli with crescents (p< 0.001).While, there was a significant relationship of proteinuria with chronicity percent (p= 0.001), this association for activity percent was not significant (p= 0.094). Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145, respectively).

Bottom Line: A significant association of serum creatinine with 24-h proteinuria (p= 0.041) was seen.Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145 respectively).In conclusion, the results from our study on biopsy-proven cases of LN largely concur with the previously reported studies from Iran and other parts of the world.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Renal biopsies play an important role in the diagnosis, management and prognosis of patients with lupus nephritis (LN).

Objectives: To determine the correlation between the pathological features of LN and the demographic, clinical and laboratory parameters.

Patients and methods: This retrospective study was conducted from 2008 to 2014 on all consecutive cases of biopsy-proven LN at a nephropathology laboratory in Iran. The demographic, clinical and laboratory data were obtained from patients(') files and the biopsy findings from the original biopsy request forms.

Results: Of the 84 patients enrolled, 69 (82.2%) were females and 15 (17.8%) males. The mean age was 32.7±12 years. The mean serum creatinine was 1.5±0.94 mg/dl and the mean 24-h proteinuria, 1.6±1.9 grams. The majority of cases belonged to classes III and IV. The extracapillary proliferation was found in 42.86% of biopsies and endocapillary proliferation in 66.67% of biopsies. Patients of class IV-LN had a higher mean serum value of creatinine in comparison to class III-LN (2.19±1.09 versus 1.2±0.56 mg/dl; p= 0.0001). There was no significant difference of 24-h proteinuria between the two classes (p= 0.882). A significant association of serum creatinine with 24-h proteinuria (p= 0.041) was seen. Serum creatinine had significant positive correlation with activity percent (p< 0.001), and chronicity percent (p= 0.006), and also with proportion of glomeruli with crescents (p < 0.001). While there was a significant relationship of proteinuria with chronicity percent (p= 0.001), this association for activity percent was not significant (p= 0.094). Furthermore, the association of proteinuria with totally sclerotic glomeruli and proportion of crescents was not statistically significant (p= 0.186 and p= 0.0145 respectively).

Conclusions: In conclusion, the results from our study on biopsy-proven cases of LN largely concur with the previously reported studies from Iran and other parts of the world.

No MeSH data available.


Related in: MedlinePlus