Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency.
Bottom Line: IC showed less variability in efficiency compared with TE and surgical injection.Troponin rise and IC flow did not differ between the percutaneous groups.In addition, no differences in safety profile were observed.
Affiliation: Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands. email@example.comShow MeSH
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Mentions: Whole-body γ-scan revealed a trend towards higher retention of MSC after surgical delivery (16 ± 4%) compared with IC (11 ± 1%) and TE (11 ± 3%), but this difference was not statistically significant (P = 0.52). Variation in delivery efficiency was less in the IC group (Fig. 2). Qualitative analysis after TE delivery showed a higher local retention of cells at the mid-papillary level in the targeted area compared with widespread distribution of cells in the infarcted area after IC infusion (Fig. 3).
Affiliation: Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands. firstname.lastname@example.org