Intrapleural delivery of MSCs attenuates acute lung injury by paracrine/endocrine mechanism.
Bottom Line: MSCs intrapleural injection significantly improved LPS-induced lung histopathology compared with PBS-treated group at day 3.There was also a significant decrease in total cell counts and protein concentration in BALF at day 7 in the MSCs -treated rats compared to PBS control group.In conclusion, treatment with intrapleural MSCs administration markedly attenuates the severity of endotoxin-induced ALI.
Affiliation: Department of Pulmonary Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China.Show MeSH
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Mentions: The distribution of intrapleural administrated DAPI-marked MSCs in rats with ALI was found to be limited to the surface of pleurae and in the pleural cavity, no fluorescent cells were found in the lung parenchyma (Fig. 1), similar to the results observed with healthy rats in our previous study .
Affiliation: Department of Pulmonary Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China.