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Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of methoxy dibenzofluorene derivatives.

Becker FF, Banik BK - Front Chem (2014)

Bottom Line: Using this hydrocarbon, a few derivatives are prepared through aromatic nitration, catalytic hydrogenation, coupling reaction with a side chain and reduction.The benzylic position of this hydrocarbon with the side chain is oxidized and reduced.This study confirms antitumor activity depends on the structures of the molecules.

View Article: PubMed Central - PubMed

Affiliation: Department of Translational Molecular Pathology, M. D. Anderson Cancer Center, The University of Texas Houston, TX USA.

ABSTRACT
Synthesis of a new methoxy dibenzofluorene through alkylation, cyclodehydration and aromatization in a one-pot operation is achieved for the first time. Using this hydrocarbon, a few derivatives are prepared through aromatic nitration, catalytic hydrogenation, coupling reaction with a side chain and reduction. The benzylic position of this hydrocarbon with the side chain is oxidized and reduced. Some of these derivatives have demonstrated excellent antitumor activities in vitro. This study confirms antitumor activity depends on the structures of the molecules.

No MeSH data available.


Synthesis of methoxy dibenzofluorene derivatives with amide side chain.
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Related In: Results  -  Collection

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S4: Synthesis of methoxy dibenzofluorene derivatives with amide side chain.


Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of methoxy dibenzofluorene derivatives.

Becker FF, Banik BK - Front Chem (2014)

Synthesis of methoxy dibenzofluorene derivatives with amide side chain.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4117931&req=5

S4: Synthesis of methoxy dibenzofluorene derivatives with amide side chain.
Bottom Line: Using this hydrocarbon, a few derivatives are prepared through aromatic nitration, catalytic hydrogenation, coupling reaction with a side chain and reduction.The benzylic position of this hydrocarbon with the side chain is oxidized and reduced.This study confirms antitumor activity depends on the structures of the molecules.

View Article: PubMed Central - PubMed

Affiliation: Department of Translational Molecular Pathology, M. D. Anderson Cancer Center, The University of Texas Houston, TX USA.

ABSTRACT
Synthesis of a new methoxy dibenzofluorene through alkylation, cyclodehydration and aromatization in a one-pot operation is achieved for the first time. Using this hydrocarbon, a few derivatives are prepared through aromatic nitration, catalytic hydrogenation, coupling reaction with a side chain and reduction. The benzylic position of this hydrocarbon with the side chain is oxidized and reduced. Some of these derivatives have demonstrated excellent antitumor activities in vitro. This study confirms antitumor activity depends on the structures of the molecules.

No MeSH data available.