Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling.
Bottom Line: TOPflash analysis revealed that Wnt activity was significantly reduced after berberine treatment, and the mechanism of which might be that berberine disrupted β-catenin transfer to nucleus through up-regulating the expression of adenomatous polyposis coli (APC) gene and stabilized APC-β-catenin complex.Berberine administration in ApcMin/+ mice exhibited fewer and smaller polyps in intestine, along with reduction in cyclin D1 and c-Myc expression.These observations indicate that berberine inhibits colon tumour formation through inhibition of Wnt/β-catenin signalling and berberine might be a promising drug for the prevention of colon cancer.
Affiliation: Cancer Research Center, Xiamen University Medical College, Xiamen, China; School of life Science, Xiamen University, Xiamen, China.Show MeSH
Related in: MedlinePlus
Mentions: Seven patients took berberine treatment immediately following polypectomy. The colonoscopy results between control and berberine administration (as described in materials and methods) are shown in Figure 5 upper panel. There were no colorectal polyp recurrences below 10 cm from the anal margin. The polyps number and size were also significantly decreased in the other part of the colon after berberine administration. Quantification of immunohistochemical staining showed that berberine decreased cyclinD1-positive cells by 68% compared in polyps between before and after berberine treatment (*P < 0.05, Fig. 5 lower panel).
Affiliation: Cancer Research Center, Xiamen University Medical College, Xiamen, China; School of life Science, Xiamen University, Xiamen, China.