Calcium ions and osteoclastogenesis initiate the induction of bone formation by coral-derived macroporous constructs.
Bottom Line: Generated tissues on days 15, 60 and 90 were analysed by histomorphometry and qRT-PCR.On day 15, up-regulation of type IV collagen characterized all the implanted constructs correlating with vascular invasion.Zoledronate-treated specimens showed an important delay in tissue patterning and morphogenesis with limited bone formation.
Affiliation: Bone Research Laboratory, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.Show MeSH
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Mentions: By day 90, auto induced bone by untreated macroporous constructs increased significantly (Fig. 4), and remodelled in blocks of osteonic lamellar bone throughout the macroporous spaces (Fig. 5A–F) with osteocytes embedded within the newly formed matrix (Fig. 5G and H). Capillary sprouting was associated with osteoclastic activity remodelling the newly formed bone (Fig. 5H).
Affiliation: Bone Research Laboratory, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.