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Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.

Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N - Aging Cell (2014)

Bottom Line: However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed.In the Kaplan-Meier analysis, females with IGF-1 levels below the median (≤ 96 ng mL(-1) ) had significantly longer survival compared with females with levels above the median, P < 0.01.We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA.

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Kaplan–Meier curves for groups with IGF-1 levels below (low IGF-1) and above (high IGF-1) the median (A–D). P-values for comparison between IGF-1 groups. (A) Females, P < 0.01. (B) Males, P = 0.83. (C) Negative history of malignancy, P = 0.42. (D) Positive history of malignancy, P < 0.01.
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fig01: Kaplan–Meier curves for groups with IGF-1 levels below (low IGF-1) and above (high IGF-1) the median (A–D). P-values for comparison between IGF-1 groups. (A) Females, P < 0.01. (B) Males, P = 0.83. (C) Negative history of malignancy, P = 0.42. (D) Positive history of malignancy, P < 0.01.

Mentions: Subject characteristics at the time of IGF-1 measurement are listed in Table 1. The survival time, as depicted by the Kaplan–Meier curves, was significantly longer in females with IGF-1 levels below the median, compared with females with IGF-1 above the median, P < 0.01 (Fig. 1A). However, this survival advantage was not observed in males (P = 0.83, Fig. 1B). There was a no significant association between IGF-1 levels and survival among individuals without a history of malignancy (Fig. 1C). Females without malignancy and with low IGF-1 exhibited a trend toward longer survival. On the other hand, in the group with a history of malignancy, individuals with low IGF-1 levels had significantly prolonged survival compared with individuals with high IGF-1 levels (P < 0.01, Fig. 1D). Among the subjects with a history of cancer, the median survival was 49.6 months in the group with low IGF-1 and 20.7 months in the group with a high IGF-1 (P < 0.01).


Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.

Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N - Aging Cell (2014)

Kaplan–Meier curves for groups with IGF-1 levels below (low IGF-1) and above (high IGF-1) the median (A–D). P-values for comparison between IGF-1 groups. (A) Females, P < 0.01. (B) Males, P = 0.83. (C) Negative history of malignancy, P = 0.42. (D) Positive history of malignancy, P < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4116456&req=5

fig01: Kaplan–Meier curves for groups with IGF-1 levels below (low IGF-1) and above (high IGF-1) the median (A–D). P-values for comparison between IGF-1 groups. (A) Females, P < 0.01. (B) Males, P = 0.83. (C) Negative history of malignancy, P = 0.42. (D) Positive history of malignancy, P < 0.01.
Mentions: Subject characteristics at the time of IGF-1 measurement are listed in Table 1. The survival time, as depicted by the Kaplan–Meier curves, was significantly longer in females with IGF-1 levels below the median, compared with females with IGF-1 above the median, P < 0.01 (Fig. 1A). However, this survival advantage was not observed in males (P = 0.83, Fig. 1B). There was a no significant association between IGF-1 levels and survival among individuals without a history of malignancy (Fig. 1C). Females without malignancy and with low IGF-1 exhibited a trend toward longer survival. On the other hand, in the group with a history of malignancy, individuals with low IGF-1 levels had significantly prolonged survival compared with individuals with high IGF-1 levels (P < 0.01, Fig. 1D). Among the subjects with a history of cancer, the median survival was 49.6 months in the group with low IGF-1 and 20.7 months in the group with a high IGF-1 (P < 0.01).

Bottom Line: However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed.In the Kaplan-Meier analysis, females with IGF-1 levels below the median (≤ 96 ng mL(-1) ) had significantly longer survival compared with females with levels above the median, P < 0.01.We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA.

Show MeSH
Related in: MedlinePlus