Limits...
Brain susceptibility weighted imaging signal changes in acute hemorrhagic anemia: an experimental study using a rabbit model.

Xia J, Xie N, Feng Y, Yin A, Liu P, Zhou R, Lin F, Teng G, Lei Y - Med. Sci. Monit. (2014)

Bottom Line: Repeated bloodletting was associated with significant reductions in red blood cell count, hemoglobin concentration, hematocrit, pH, and PaCO2, and elevations of blood lactate and PaO2.Repeated bloodletting (5 occasions) caused significant (P<0.05) decreases in the SWI signals of the frontal cortex (from 63.10±22.82 to 37.70±4.32), temporal lobe (from 52.50±20.29 to 42.60±5.54), and thalamus (from 60.40±20.29 to 39.40±3.47), but was without effect in the frontal white matter.The effect of hemorrhage on the brain is reflected by SWI signal changes in the cerebral cortex and gray matter nuclei.

View Article: PubMed Central - PubMed

Affiliation: Department of Rodiology, Second People's Hospital of Shenzhen City, First Affiliated Hospital of Shenzhen University, Shenzhen, China (mainland).

ABSTRACT

Background: The aim of this study was to investigate susceptibility-weighted imaging (SWI) signal changes in different brain regions in a rabbit model of acute hemorrhagic anemia.

Material/methods: Ten New Zealand white rabbits were used for construction of the model of acute hemorrhagic anemia. Signal intensities of SWI images of the bilateral frontal cortex, frontal white matter, temporal lobe, and thalamic nuclei were measured. In addition, the cerebral gray-white contrast and venous structures of the SWI images were evaluated by an experienced physician.

Results: Repeated bloodletting was associated with significant reductions in red blood cell count, hemoglobin concentration, hematocrit, pH, and PaCO2, and elevations of blood lactate and PaO2. In normal status, the SWI signal intensity was significantly higher in the frontal cortex than in the frontal white matter (63.10±22.82 vs. 52.50±20.29; P<0.05). Repeated bloodletting (5 occasions) caused significant (P<0.05) decreases in the SWI signals of the frontal cortex (from 63.10±22.82 to 37.70±4.32), temporal lobe (from 52.50±20.29 to 42.60±5.54), and thalamus (from 60.40±20.29 to 39.40±3.47), but was without effect in the frontal white matter. The cerebral white-gray contrast and venous structures were clearer after bloodletting than before bloodletting.

Conclusions: The effect of hemorrhage on the brain is reflected by SWI signal changes in the cerebral cortex and gray matter nuclei.

Show MeSH

Related in: MedlinePlus

The effects of repeated bloodletting on the SWI signal intensities of selected regions of the brain. Repeated bloodletting was associated with reductions in the mean SWI signal intensities of the frontal cortex, temporal lobe, and thalamus, but not of the frontal white matter. Data are shown as means ± standard deviations. Compared with the control (pre-bleed) value, significant (P<0.05) decreases in SWI signal intensity were observed for the frontal cortex, temporal lobe, and thalamus following the second, third, fourth, and fifth bloodlettings; the values after the first bloodletting were not significantly different from the control (pre-bleed) values. For the frontal white matter, none of the values after bloodletting were significantly different from the control (pre-bleed) value.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4116343&req=5

f3-medscimonit-20-1291: The effects of repeated bloodletting on the SWI signal intensities of selected regions of the brain. Repeated bloodletting was associated with reductions in the mean SWI signal intensities of the frontal cortex, temporal lobe, and thalamus, but not of the frontal white matter. Data are shown as means ± standard deviations. Compared with the control (pre-bleed) value, significant (P<0.05) decreases in SWI signal intensity were observed for the frontal cortex, temporal lobe, and thalamus following the second, third, fourth, and fifth bloodlettings; the values after the first bloodletting were not significantly different from the control (pre-bleed) values. For the frontal white matter, none of the values after bloodletting were significantly different from the control (pre-bleed) value.

Mentions: The SWI signals of rabbit brains were acquired before and after bloodletting. Figure 2 shows representative SWI and corresponding T2-weighted images of the brain of a rabbit, obtained at the superior aspect of the olfactory bulb, the border of the olfactory bulb, the thalamus, and the cerebellum; also evident are examples of the ROIs chosen for analyses of the SWI images (see Materials and Methods). The mean SWI signal intensities (arbitrary units) of the frontal cortex, frontal white matter, temporal lobe, and thalamus, before and after bloodletting, are presented in Figure 3. The control (pre-bleed) SWI signal intensity of the frontal white matter was significantly lower than that of the frontal cortex (52.50±20.29 vs. 63.10±22.82; P<0.05). Bloodletting was not associated with any significant changes in the SWI signal of the frontal white matter. In contrast, there were significant (P<0.05) decreases in the SWI signals of the frontal cortex, temporal lobe, and thalamus after the second, third, fourth, and fifth bloodletting procedures, compared with the corresponding control (pre-bleed) values. Following the fifth bloodletting, the SWI signal intensities of the frontal cortex, temporal lobe, and thalamus were 37.70±4.32, 42.60±5.54, and 39.40±3.47, compared with corresponding control (pre-bleed) values of 63.10±22.82, 52.50±20.29, and 60.40±20.29, respectively (P<0.05).


Brain susceptibility weighted imaging signal changes in acute hemorrhagic anemia: an experimental study using a rabbit model.

Xia J, Xie N, Feng Y, Yin A, Liu P, Zhou R, Lin F, Teng G, Lei Y - Med. Sci. Monit. (2014)

The effects of repeated bloodletting on the SWI signal intensities of selected regions of the brain. Repeated bloodletting was associated with reductions in the mean SWI signal intensities of the frontal cortex, temporal lobe, and thalamus, but not of the frontal white matter. Data are shown as means ± standard deviations. Compared with the control (pre-bleed) value, significant (P<0.05) decreases in SWI signal intensity were observed for the frontal cortex, temporal lobe, and thalamus following the second, third, fourth, and fifth bloodlettings; the values after the first bloodletting were not significantly different from the control (pre-bleed) values. For the frontal white matter, none of the values after bloodletting were significantly different from the control (pre-bleed) value.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4116343&req=5

f3-medscimonit-20-1291: The effects of repeated bloodletting on the SWI signal intensities of selected regions of the brain. Repeated bloodletting was associated with reductions in the mean SWI signal intensities of the frontal cortex, temporal lobe, and thalamus, but not of the frontal white matter. Data are shown as means ± standard deviations. Compared with the control (pre-bleed) value, significant (P<0.05) decreases in SWI signal intensity were observed for the frontal cortex, temporal lobe, and thalamus following the second, third, fourth, and fifth bloodlettings; the values after the first bloodletting were not significantly different from the control (pre-bleed) values. For the frontal white matter, none of the values after bloodletting were significantly different from the control (pre-bleed) value.
Mentions: The SWI signals of rabbit brains were acquired before and after bloodletting. Figure 2 shows representative SWI and corresponding T2-weighted images of the brain of a rabbit, obtained at the superior aspect of the olfactory bulb, the border of the olfactory bulb, the thalamus, and the cerebellum; also evident are examples of the ROIs chosen for analyses of the SWI images (see Materials and Methods). The mean SWI signal intensities (arbitrary units) of the frontal cortex, frontal white matter, temporal lobe, and thalamus, before and after bloodletting, are presented in Figure 3. The control (pre-bleed) SWI signal intensity of the frontal white matter was significantly lower than that of the frontal cortex (52.50±20.29 vs. 63.10±22.82; P<0.05). Bloodletting was not associated with any significant changes in the SWI signal of the frontal white matter. In contrast, there were significant (P<0.05) decreases in the SWI signals of the frontal cortex, temporal lobe, and thalamus after the second, third, fourth, and fifth bloodletting procedures, compared with the corresponding control (pre-bleed) values. Following the fifth bloodletting, the SWI signal intensities of the frontal cortex, temporal lobe, and thalamus were 37.70±4.32, 42.60±5.54, and 39.40±3.47, compared with corresponding control (pre-bleed) values of 63.10±22.82, 52.50±20.29, and 60.40±20.29, respectively (P<0.05).

Bottom Line: Repeated bloodletting was associated with significant reductions in red blood cell count, hemoglobin concentration, hematocrit, pH, and PaCO2, and elevations of blood lactate and PaO2.Repeated bloodletting (5 occasions) caused significant (P<0.05) decreases in the SWI signals of the frontal cortex (from 63.10±22.82 to 37.70±4.32), temporal lobe (from 52.50±20.29 to 42.60±5.54), and thalamus (from 60.40±20.29 to 39.40±3.47), but was without effect in the frontal white matter.The effect of hemorrhage on the brain is reflected by SWI signal changes in the cerebral cortex and gray matter nuclei.

View Article: PubMed Central - PubMed

Affiliation: Department of Rodiology, Second People's Hospital of Shenzhen City, First Affiliated Hospital of Shenzhen University, Shenzhen, China (mainland).

ABSTRACT

Background: The aim of this study was to investigate susceptibility-weighted imaging (SWI) signal changes in different brain regions in a rabbit model of acute hemorrhagic anemia.

Material/methods: Ten New Zealand white rabbits were used for construction of the model of acute hemorrhagic anemia. Signal intensities of SWI images of the bilateral frontal cortex, frontal white matter, temporal lobe, and thalamic nuclei were measured. In addition, the cerebral gray-white contrast and venous structures of the SWI images were evaluated by an experienced physician.

Results: Repeated bloodletting was associated with significant reductions in red blood cell count, hemoglobin concentration, hematocrit, pH, and PaCO2, and elevations of blood lactate and PaO2. In normal status, the SWI signal intensity was significantly higher in the frontal cortex than in the frontal white matter (63.10±22.82 vs. 52.50±20.29; P<0.05). Repeated bloodletting (5 occasions) caused significant (P<0.05) decreases in the SWI signals of the frontal cortex (from 63.10±22.82 to 37.70±4.32), temporal lobe (from 52.50±20.29 to 42.60±5.54), and thalamus (from 60.40±20.29 to 39.40±3.47), but was without effect in the frontal white matter. The cerebral white-gray contrast and venous structures were clearer after bloodletting than before bloodletting.

Conclusions: The effect of hemorrhage on the brain is reflected by SWI signal changes in the cerebral cortex and gray matter nuclei.

Show MeSH
Related in: MedlinePlus