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Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation.

Won JC, Park CY, Oh SW, Lee ES, Youn BS, Kim MS - PLoS ONE (2014)

Bottom Line: Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation.Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4.Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

ABSTRACT
Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.

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Relationship between plasma clusterin levels and metabolic syndrome.(A) Fasting plasma clusterin concentrations in subjects with and without metabolic syndrome. White bars: subjects without metabolic syndrome (n = 151 for all, 73 for men, and 78 for women), Black bars: subjects with metabolic syndrome (n = 53 for all, 38 for men, and 15 for women). (B) Plasma clusterin concentrations in relation to increases in the number of metabolic syndrome components. The breakdown of the number of components in the study cohort was as follows: 0 (n = 39), 1 (n = 57), 2 (n = 55) and 3 or more (n = 53). Data are the mean ± SE.
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pone-0103351-g001: Relationship between plasma clusterin levels and metabolic syndrome.(A) Fasting plasma clusterin concentrations in subjects with and without metabolic syndrome. White bars: subjects without metabolic syndrome (n = 151 for all, 73 for men, and 78 for women), Black bars: subjects with metabolic syndrome (n = 53 for all, 38 for men, and 15 for women). (B) Plasma clusterin concentrations in relation to increases in the number of metabolic syndrome components. The breakdown of the number of components in the study cohort was as follows: 0 (n = 39), 1 (n = 57), 2 (n = 55) and 3 or more (n = 53). Data are the mean ± SE.

Mentions: Plasma clusterin levels were higher in subjects with metabolic syndrome than in those without metabolic syndrome (Fig. 1A). Sex-stratified analysis also revealed a tendency of increase in circulating clusterin levels in individuals with metabolic syndrome (Fig. 1A). Furthermore, plasma clusterin levels showed an upward trend with increased metabolic syndrome component numbers (Fig. 1B).


Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation.

Won JC, Park CY, Oh SW, Lee ES, Youn BS, Kim MS - PLoS ONE (2014)

Relationship between plasma clusterin levels and metabolic syndrome.(A) Fasting plasma clusterin concentrations in subjects with and without metabolic syndrome. White bars: subjects without metabolic syndrome (n = 151 for all, 73 for men, and 78 for women), Black bars: subjects with metabolic syndrome (n = 53 for all, 38 for men, and 15 for women). (B) Plasma clusterin concentrations in relation to increases in the number of metabolic syndrome components. The breakdown of the number of components in the study cohort was as follows: 0 (n = 39), 1 (n = 57), 2 (n = 55) and 3 or more (n = 53). Data are the mean ± SE.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4116172&req=5

pone-0103351-g001: Relationship between plasma clusterin levels and metabolic syndrome.(A) Fasting plasma clusterin concentrations in subjects with and without metabolic syndrome. White bars: subjects without metabolic syndrome (n = 151 for all, 73 for men, and 78 for women), Black bars: subjects with metabolic syndrome (n = 53 for all, 38 for men, and 15 for women). (B) Plasma clusterin concentrations in relation to increases in the number of metabolic syndrome components. The breakdown of the number of components in the study cohort was as follows: 0 (n = 39), 1 (n = 57), 2 (n = 55) and 3 or more (n = 53). Data are the mean ± SE.
Mentions: Plasma clusterin levels were higher in subjects with metabolic syndrome than in those without metabolic syndrome (Fig. 1A). Sex-stratified analysis also revealed a tendency of increase in circulating clusterin levels in individuals with metabolic syndrome (Fig. 1A). Furthermore, plasma clusterin levels showed an upward trend with increased metabolic syndrome component numbers (Fig. 1B).

Bottom Line: Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation.Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4.Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

ABSTRACT
Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.

Show MeSH
Related in: MedlinePlus