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Reference ranges for induced sputum eosinophil counts in Korean adult population.

Kim MY, Jo EJ, Lee SE, Lee SY, Song WJ, Kim TW, Hur GY, Lee JH, Kim TB, Park HW, Chang YS, Park HS, Min KU, Cho SH - Asia Pac Allergy (2014)

Bottom Line: Adequate sputum samples were successfully collected from 81 subjects (38.9%).The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, p=0.030).The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan 614-735, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

ABSTRACT

Background: Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults.

Objective: The purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults.

Methods: A total of 208 healthy nonasthmatic adults were recruited. Sputum induction and processing followed the international standard protocols.

Results: Adequate sputum samples were successfully collected from 81 subjects (38.9%). The upper 90 percentile for sputum eosinophil was calculated as 3.5%. The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, p=0.030). However, no significant correlations were found with age, gender, body mass index, smoking status, blood eosinophil, or fractional exhaled nitric oxide levels.

Conclusion: Current study was the first attempt to determine the reference ranges of induced sputum eosinophils in Korean adults. The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.

No MeSH data available.


Related in: MedlinePlus

Distribution of induced sputum eosinophils in 81 normal subjects.
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Figure 1: Distribution of induced sputum eosinophils in 81 normal subjects.

Mentions: The distribution of induced sputum inflammatory cells in healthy subjects was described in Table 2. Macrophage and neutrophil were predominant cells in induced sputum. Macrophage had a median of 71.3% (range, 0-97.3%), and the upper 90 percentile of 89.2%. Neutrophil had a median of 24.7% (range, 0.7-100%), and the upper 90 percentile of 96.0%. Eosinophil had a median of 0% (range, 0-11%), and the upper 90 percentile of 3.5%. The distribution of induced sputum eosinophil was also presented in Fig. 1.


Reference ranges for induced sputum eosinophil counts in Korean adult population.

Kim MY, Jo EJ, Lee SE, Lee SY, Song WJ, Kim TW, Hur GY, Lee JH, Kim TB, Park HW, Chang YS, Park HS, Min KU, Cho SH - Asia Pac Allergy (2014)

Distribution of induced sputum eosinophils in 81 normal subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4116041&req=5

Figure 1: Distribution of induced sputum eosinophils in 81 normal subjects.
Mentions: The distribution of induced sputum inflammatory cells in healthy subjects was described in Table 2. Macrophage and neutrophil were predominant cells in induced sputum. Macrophage had a median of 71.3% (range, 0-97.3%), and the upper 90 percentile of 89.2%. Neutrophil had a median of 24.7% (range, 0.7-100%), and the upper 90 percentile of 96.0%. Eosinophil had a median of 0% (range, 0-11%), and the upper 90 percentile of 3.5%. The distribution of induced sputum eosinophil was also presented in Fig. 1.

Bottom Line: Adequate sputum samples were successfully collected from 81 subjects (38.9%).The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, p=0.030).The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan 614-735, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

ABSTRACT

Background: Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults.

Objective: The purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults.

Methods: A total of 208 healthy nonasthmatic adults were recruited. Sputum induction and processing followed the international standard protocols.

Results: Adequate sputum samples were successfully collected from 81 subjects (38.9%). The upper 90 percentile for sputum eosinophil was calculated as 3.5%. The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, p=0.030). However, no significant correlations were found with age, gender, body mass index, smoking status, blood eosinophil, or fractional exhaled nitric oxide levels.

Conclusion: Current study was the first attempt to determine the reference ranges of induced sputum eosinophils in Korean adults. The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.

No MeSH data available.


Related in: MedlinePlus