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Nucleus reuniens of the thalamus contains head direction cells.

Jankowski MM, Islam MN, Wright NF, Vann SD, Erichsen JT, Aggleton JP, O'Mara SM - Elife (2014)

Bottom Line: These 'head direction' cells are largely confined to a closely-connected network of sites.We describe, for the first time, a population of head direction cells in nucleus reuniens of the thalamus in the freely-moving rat.This novel subcortical head direction signal potentially modulates the hippocampal CA fields directly and, thus, informs spatial processing and memory.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

ABSTRACT
Discrete populations of brain cells signal heading direction, rather like a compass. These 'head direction' cells are largely confined to a closely-connected network of sites. We describe, for the first time, a population of head direction cells in nucleus reuniens of the thalamus in the freely-moving rat. This novel subcortical head direction signal potentially modulates the hippocampal CA fields directly and, thus, informs spatial processing and memory.

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Head direction cells recorded in the nucleus reuniens.(A) 18 representative head direction (HD) cells in nucleus reuniens (NRe); (B) NRe location on a coronal (left) and corresponding sagittal (right) rat brain section (adapted from Paxinos and Watson, 2005); (C) representative histological specimen showing electrode track (left); recording positions corresponding to cell locations presented in panel a (upper right inset) showing location of NRe and detailed atlas (lower right inset); (D) representative recordings showing multi-day stability of HD cells: a representative cell recorded on each day of 16 days (multiple transitions from light-dark-light, and environmental transformations from circle to square to circle). The solid line is the mean spike waveform and dashed lines are M ± SD of the spike waveform. The green outline shows predicted firing rates given the proportion of time the animal spent looking in each direction, calculated according to the distributive hypothesis.DOI:http://dx.doi.org/10.7554/eLife.03075.003
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fig1: Head direction cells recorded in the nucleus reuniens.(A) 18 representative head direction (HD) cells in nucleus reuniens (NRe); (B) NRe location on a coronal (left) and corresponding sagittal (right) rat brain section (adapted from Paxinos and Watson, 2005); (C) representative histological specimen showing electrode track (left); recording positions corresponding to cell locations presented in panel a (upper right inset) showing location of NRe and detailed atlas (lower right inset); (D) representative recordings showing multi-day stability of HD cells: a representative cell recorded on each day of 16 days (multiple transitions from light-dark-light, and environmental transformations from circle to square to circle). The solid line is the mean spike waveform and dashed lines are M ± SD of the spike waveform. The green outline shows predicted firing rates given the proportion of time the animal spent looking in each direction, calculated according to the distributive hypothesis.DOI:http://dx.doi.org/10.7554/eLife.03075.003

Mentions: Lighting conditions were systematically varied across foraging sessions for 10 cells. The animal foraged during light-dark-light sessions (each 20 min). Light removal did not affect NRe head directional activity (Figure 1).10.7554/eLife.03075.003Figure 1.Head direction cells recorded in the nucleus reuniens.


Nucleus reuniens of the thalamus contains head direction cells.

Jankowski MM, Islam MN, Wright NF, Vann SD, Erichsen JT, Aggleton JP, O'Mara SM - Elife (2014)

Head direction cells recorded in the nucleus reuniens.(A) 18 representative head direction (HD) cells in nucleus reuniens (NRe); (B) NRe location on a coronal (left) and corresponding sagittal (right) rat brain section (adapted from Paxinos and Watson, 2005); (C) representative histological specimen showing electrode track (left); recording positions corresponding to cell locations presented in panel a (upper right inset) showing location of NRe and detailed atlas (lower right inset); (D) representative recordings showing multi-day stability of HD cells: a representative cell recorded on each day of 16 days (multiple transitions from light-dark-light, and environmental transformations from circle to square to circle). The solid line is the mean spike waveform and dashed lines are M ± SD of the spike waveform. The green outline shows predicted firing rates given the proportion of time the animal spent looking in each direction, calculated according to the distributive hypothesis.DOI:http://dx.doi.org/10.7554/eLife.03075.003
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4115655&req=5

fig1: Head direction cells recorded in the nucleus reuniens.(A) 18 representative head direction (HD) cells in nucleus reuniens (NRe); (B) NRe location on a coronal (left) and corresponding sagittal (right) rat brain section (adapted from Paxinos and Watson, 2005); (C) representative histological specimen showing electrode track (left); recording positions corresponding to cell locations presented in panel a (upper right inset) showing location of NRe and detailed atlas (lower right inset); (D) representative recordings showing multi-day stability of HD cells: a representative cell recorded on each day of 16 days (multiple transitions from light-dark-light, and environmental transformations from circle to square to circle). The solid line is the mean spike waveform and dashed lines are M ± SD of the spike waveform. The green outline shows predicted firing rates given the proportion of time the animal spent looking in each direction, calculated according to the distributive hypothesis.DOI:http://dx.doi.org/10.7554/eLife.03075.003
Mentions: Lighting conditions were systematically varied across foraging sessions for 10 cells. The animal foraged during light-dark-light sessions (each 20 min). Light removal did not affect NRe head directional activity (Figure 1).10.7554/eLife.03075.003Figure 1.Head direction cells recorded in the nucleus reuniens.

Bottom Line: These 'head direction' cells are largely confined to a closely-connected network of sites.We describe, for the first time, a population of head direction cells in nucleus reuniens of the thalamus in the freely-moving rat.This novel subcortical head direction signal potentially modulates the hippocampal CA fields directly and, thus, informs spatial processing and memory.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

ABSTRACT
Discrete populations of brain cells signal heading direction, rather like a compass. These 'head direction' cells are largely confined to a closely-connected network of sites. We describe, for the first time, a population of head direction cells in nucleus reuniens of the thalamus in the freely-moving rat. This novel subcortical head direction signal potentially modulates the hippocampal CA fields directly and, thus, informs spatial processing and memory.

Show MeSH
Related in: MedlinePlus