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Primary chondrosarcoma presenting as an intrathoracic mass: A report of three cases.

Wang XY, Hu S, Guo LC, Chen J, Zhu M, Yao FR, Hu CH - Oncol Lett (2014)

Bottom Line: Clinically, one case presented with cough and blood sputum, while the other two cases of primary intrathoracic chondrosarcoma were found incidently during a routine health examination.Radiologically, the chondrosarcomas presented as large masses with intratumoral calcification.To date, all patients have been followed up for between two and three years and are alive.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

ABSTRACT
Primary intrathoracic chondrosarcomas are rare tumors. The present study reports three cases of primary intrathoracic chondrosarcomas in two males and one female aged between 45 and 64 years. Clinically, one case presented with cough and blood sputum, while the other two cases of primary intrathoracic chondrosarcoma were found incidently during a routine health examination. Radiologically, the chondrosarcomas presented as large masses with intratumoral calcification. Chondrosarcoma should be distinguished from other calcified pulmonary lesions. In this study, all three cases underwent surgical treatment, and in one case, the surgery was accompanied by radiotherapy. To date, all patients have been followed up for between two and three years and are alive.

No MeSH data available.


Related in: MedlinePlus

(A) Posteroanterior and (B) left lateral radiographs showing a round mass in the left upper lung lobe. (C) Non-contrast chest CT scan showing an oval mass with intratumoral calcification in the anterior segment of the left upper lobe. The mass was found to be closely attached to the adjacent pleura. (D) Chest CT scan with intravenous contrast showing heterogeneously enhanced mass. (E) Microscopic findings of the tumor showing pleomorphic tumor cells with areas of chondroid differentiation. Hematoxylin and eosin staining; magnification, ×100. (F) Immunohistochemistry showing positive cluster of differentiation (CD)99 expression in the tumor cells. CT, computed tomography.
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f1-ol-08-03-1151: (A) Posteroanterior and (B) left lateral radiographs showing a round mass in the left upper lung lobe. (C) Non-contrast chest CT scan showing an oval mass with intratumoral calcification in the anterior segment of the left upper lobe. The mass was found to be closely attached to the adjacent pleura. (D) Chest CT scan with intravenous contrast showing heterogeneously enhanced mass. (E) Microscopic findings of the tumor showing pleomorphic tumor cells with areas of chondroid differentiation. Hematoxylin and eosin staining; magnification, ×100. (F) Immunohistochemistry showing positive cluster of differentiation (CD)99 expression in the tumor cells. CT, computed tomography.

Mentions: A 52-year-old female presented to the First Affiliated Hospital of Soochow University (Suzhou, Jiangsu) with an intermittent cough and bloody sputum that had persisted for four months. A chest roentgenogram revealed a homogeneous, round, well-defined shadow in the left lung (Fig. 1A and B). Computed tomography (CT) revealed an irregular hyperdense lung mass with coarse intratumoral calcifications in the anterior segment of the left upper lobe. Part of the mass was closely attached to the pleura, but there was no cartilage or bone destruction (Fig. 1C). The mass was heterogeneously enhanced upon the administration of contrast medium (Fig. 1D). The mass was completely resected using a left thoracotomy and was easily separated from the parietal pleura. Grossly, the resected mass was white in color and measured 5×4×4 cm, with necrosis at the cut surface. Two small nodules could be observed on the surface of the pleura and diaphragm. The final pathological diagnosis was of a dedifferentiated chondrosarcoma (Fig. 1E). Immunohistochemically, the tumor was positive for S-100 in the cartilaginous component and cluster of differentiation (CD)99 in the sarcomatous component (Fig. 1F), but negative for smooth muscle actin, CD34, CD117, B-cell lymphoma-2 and cytokeratin 18. The patient received no further therapy. To date, the patient has been followed up for three years and is alive.


Primary chondrosarcoma presenting as an intrathoracic mass: A report of three cases.

Wang XY, Hu S, Guo LC, Chen J, Zhu M, Yao FR, Hu CH - Oncol Lett (2014)

(A) Posteroanterior and (B) left lateral radiographs showing a round mass in the left upper lung lobe. (C) Non-contrast chest CT scan showing an oval mass with intratumoral calcification in the anterior segment of the left upper lobe. The mass was found to be closely attached to the adjacent pleura. (D) Chest CT scan with intravenous contrast showing heterogeneously enhanced mass. (E) Microscopic findings of the tumor showing pleomorphic tumor cells with areas of chondroid differentiation. Hematoxylin and eosin staining; magnification, ×100. (F) Immunohistochemistry showing positive cluster of differentiation (CD)99 expression in the tumor cells. CT, computed tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4114614&req=5

f1-ol-08-03-1151: (A) Posteroanterior and (B) left lateral radiographs showing a round mass in the left upper lung lobe. (C) Non-contrast chest CT scan showing an oval mass with intratumoral calcification in the anterior segment of the left upper lobe. The mass was found to be closely attached to the adjacent pleura. (D) Chest CT scan with intravenous contrast showing heterogeneously enhanced mass. (E) Microscopic findings of the tumor showing pleomorphic tumor cells with areas of chondroid differentiation. Hematoxylin and eosin staining; magnification, ×100. (F) Immunohistochemistry showing positive cluster of differentiation (CD)99 expression in the tumor cells. CT, computed tomography.
Mentions: A 52-year-old female presented to the First Affiliated Hospital of Soochow University (Suzhou, Jiangsu) with an intermittent cough and bloody sputum that had persisted for four months. A chest roentgenogram revealed a homogeneous, round, well-defined shadow in the left lung (Fig. 1A and B). Computed tomography (CT) revealed an irregular hyperdense lung mass with coarse intratumoral calcifications in the anterior segment of the left upper lobe. Part of the mass was closely attached to the pleura, but there was no cartilage or bone destruction (Fig. 1C). The mass was heterogeneously enhanced upon the administration of contrast medium (Fig. 1D). The mass was completely resected using a left thoracotomy and was easily separated from the parietal pleura. Grossly, the resected mass was white in color and measured 5×4×4 cm, with necrosis at the cut surface. Two small nodules could be observed on the surface of the pleura and diaphragm. The final pathological diagnosis was of a dedifferentiated chondrosarcoma (Fig. 1E). Immunohistochemically, the tumor was positive for S-100 in the cartilaginous component and cluster of differentiation (CD)99 in the sarcomatous component (Fig. 1F), but negative for smooth muscle actin, CD34, CD117, B-cell lymphoma-2 and cytokeratin 18. The patient received no further therapy. To date, the patient has been followed up for three years and is alive.

Bottom Line: Clinically, one case presented with cough and blood sputum, while the other two cases of primary intrathoracic chondrosarcoma were found incidently during a routine health examination.Radiologically, the chondrosarcomas presented as large masses with intratumoral calcification.To date, all patients have been followed up for between two and three years and are alive.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

ABSTRACT
Primary intrathoracic chondrosarcomas are rare tumors. The present study reports three cases of primary intrathoracic chondrosarcomas in two males and one female aged between 45 and 64 years. Clinically, one case presented with cough and blood sputum, while the other two cases of primary intrathoracic chondrosarcoma were found incidently during a routine health examination. Radiologically, the chondrosarcomas presented as large masses with intratumoral calcification. Chondrosarcoma should be distinguished from other calcified pulmonary lesions. In this study, all three cases underwent surgical treatment, and in one case, the surgery was accompanied by radiotherapy. To date, all patients have been followed up for between two and three years and are alive.

No MeSH data available.


Related in: MedlinePlus