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Lymphatic invasion of micropapillary cancer cells is associated with a poor prognosis of pathological stage IA lung adenocarcinomas.

Hirano H, Maeda H, Takeuchi Y, Susaki Y, Kobayashi R, Hayashi A, Ose N, Yamaguchi T, Yokota S, Mori M - Oncol Lett (2014)

Bottom Line: The cancer cells of lung adenocarcinoma with a micropapillary pattern (MPP) have been found to frequently invade lymphatic vessels, and the prognosis of patients with lung adenocarcinoma with an MPP is poor.By contrast, the area of the MPP component in each adenocarcinoma was <25%.These findings suggest that cancer cells in MPP components have a high capacity to invade lymphatic vessels and that their high invasive capacity may be associated with a poor prognosis in patients with adenocarcinoma with an MPP component.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Toneyama National Hospital, Toyonaka, Osaka 560-8552, Japan.

ABSTRACT
The cancer cells of lung adenocarcinoma with a micropapillary pattern (MPP) have been found to frequently invade lymphatic vessels, and the prognosis of patients with lung adenocarcinoma with an MPP is poor. In the present study, the cancer cells of lung adenocarcinomas containing an MPP were found to express vimentin more extensively than those in lung adenocarcinoma without an MPP. The contribution of cancer cells in the MPP component to adenocarcinoma lymphatic invasion was assessed using vimentin as a marker. Vimentin expression was analyzed in the cancer cells present in each lymphatic vessel and compared with the expression of vimentin in the cancer cells in the adenocarcinomas without an MPP component. The results showed that the cancer cells in the lymphatic vessels expressed vimentin more extensively than those in the adenocarcinoma components without an MPP, suggesting that cancer cells derived from an MPP component are present in the lymphatic vessels. By contrast, the area of the MPP component in each adenocarcinoma was <25%. These findings suggest that cancer cells in MPP components have a high capacity to invade lymphatic vessels and that their high invasive capacity may be associated with a poor prognosis in patients with adenocarcinoma with an MPP component.

No MeSH data available.


Related in: MedlinePlus

Micropapillary pattern in lung adenocarcinoma exhibiting papillary tufts lacking a central fibrovascular core (hematoxylin and eosin stain; magnification, ×20)
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f1-ol-08-03-1107: Micropapillary pattern in lung adenocarcinoma exhibiting papillary tufts lacking a central fibrovascular core (hematoxylin and eosin stain; magnification, ×20)

Mentions: The diameters of the resected tumors were measured and the longest diameter was regarded as the tumor diameter. The tumors were fixed in 0.01 M phosphate-buffered saline containing 10% formalin (pH 7.4) and several paraffin-embedded tumor blocks were generated from each tumor. Tumor sections (4-mm thick) were then generated from each tumor block. Sections were either used for hematoxylin and eosin staining or immunohistochemistry. Tumors were histologically classified according to the International Association for the Study of Lung Cancer (6). MPPs were identified as small tufts without a fibrovascular core, present in the alveolar spaces or in spaces encased within thin walls of connective tissues (Fig. 1), as described previously (2–4).


Lymphatic invasion of micropapillary cancer cells is associated with a poor prognosis of pathological stage IA lung adenocarcinomas.

Hirano H, Maeda H, Takeuchi Y, Susaki Y, Kobayashi R, Hayashi A, Ose N, Yamaguchi T, Yokota S, Mori M - Oncol Lett (2014)

Micropapillary pattern in lung adenocarcinoma exhibiting papillary tufts lacking a central fibrovascular core (hematoxylin and eosin stain; magnification, ×20)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4114577&req=5

f1-ol-08-03-1107: Micropapillary pattern in lung adenocarcinoma exhibiting papillary tufts lacking a central fibrovascular core (hematoxylin and eosin stain; magnification, ×20)
Mentions: The diameters of the resected tumors were measured and the longest diameter was regarded as the tumor diameter. The tumors were fixed in 0.01 M phosphate-buffered saline containing 10% formalin (pH 7.4) and several paraffin-embedded tumor blocks were generated from each tumor. Tumor sections (4-mm thick) were then generated from each tumor block. Sections were either used for hematoxylin and eosin staining or immunohistochemistry. Tumors were histologically classified according to the International Association for the Study of Lung Cancer (6). MPPs were identified as small tufts without a fibrovascular core, present in the alveolar spaces or in spaces encased within thin walls of connective tissues (Fig. 1), as described previously (2–4).

Bottom Line: The cancer cells of lung adenocarcinoma with a micropapillary pattern (MPP) have been found to frequently invade lymphatic vessels, and the prognosis of patients with lung adenocarcinoma with an MPP is poor.By contrast, the area of the MPP component in each adenocarcinoma was <25%.These findings suggest that cancer cells in MPP components have a high capacity to invade lymphatic vessels and that their high invasive capacity may be associated with a poor prognosis in patients with adenocarcinoma with an MPP component.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Toneyama National Hospital, Toyonaka, Osaka 560-8552, Japan.

ABSTRACT
The cancer cells of lung adenocarcinoma with a micropapillary pattern (MPP) have been found to frequently invade lymphatic vessels, and the prognosis of patients with lung adenocarcinoma with an MPP is poor. In the present study, the cancer cells of lung adenocarcinomas containing an MPP were found to express vimentin more extensively than those in lung adenocarcinoma without an MPP. The contribution of cancer cells in the MPP component to adenocarcinoma lymphatic invasion was assessed using vimentin as a marker. Vimentin expression was analyzed in the cancer cells present in each lymphatic vessel and compared with the expression of vimentin in the cancer cells in the adenocarcinomas without an MPP component. The results showed that the cancer cells in the lymphatic vessels expressed vimentin more extensively than those in the adenocarcinoma components without an MPP, suggesting that cancer cells derived from an MPP component are present in the lymphatic vessels. By contrast, the area of the MPP component in each adenocarcinoma was <25%. These findings suggest that cancer cells in MPP components have a high capacity to invade lymphatic vessels and that their high invasive capacity may be associated with a poor prognosis in patients with adenocarcinoma with an MPP component.

No MeSH data available.


Related in: MedlinePlus