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Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin.

Evstatiev R, Bukaty A, Jimenez K, Kulnigg-Dabsch S, Surman L, Schmid W, Eferl R, Lippert K, Scheiber-Mojdehkar B, Kvasnicka HM, Khare V, Gasche C - Am. J. Hematol. (2014)

Bottom Line: Moreover, platelets produced in iron deficient animals displayed a higher mean platelet volume and increased aggregation.Iron deficiency did not alter the production of hematopoietic growth factors such as thrombopoietin, interleukin 6 or interleukin 11.Megakaryocytic cell lines grown in iron-depleted conditions exhibited reduced proliferation but increased ploidy and cell size.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory on Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria.

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 Iron deficiency induces thrombocytosis and enhances platelet aggregation. Development of ID was paralleled by a rise in platelet counts (A) and an increase in MPV (B; n=4 per group). Light transmission aggregometry demonstrated that, in ID, platelet aggregation was enhanced as reflected by the significantly higher area under the aggregometry curve (C; n=8 per group).
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ajh23682-fig-0002:  Iron deficiency induces thrombocytosis and enhances platelet aggregation. Development of ID was paralleled by a rise in platelet counts (A) and an increase in MPV (B; n=4 per group). Light transmission aggregometry demonstrated that, in ID, platelet aggregation was enhanced as reflected by the significantly higher area under the aggregometry curve (C; n=8 per group).

Mentions: In parallel, platelet counts increased after week 1 and reached a plateau at week 4. The mean platelet count across all time points was 1445 ± 276 G L−1 vs. 976 ± 97 G L−1 (ID vs. controls; P < 0.001) (Fig. 2A). The mean platelet volume (MPV) increased in the ID group with a mean of 11.2 fL compared to 9.5 fL in controls (P = 0.004, Fig. 2B). Light transmission aggregometry after stimulation with ADP demonstrated a considerably larger AUC in ID (P = 0.001 by ANOVA; Fig. 2C).


Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin.

Evstatiev R, Bukaty A, Jimenez K, Kulnigg-Dabsch S, Surman L, Schmid W, Eferl R, Lippert K, Scheiber-Mojdehkar B, Kvasnicka HM, Khare V, Gasche C - Am. J. Hematol. (2014)

 Iron deficiency induces thrombocytosis and enhances platelet aggregation. Development of ID was paralleled by a rise in platelet counts (A) and an increase in MPV (B; n=4 per group). Light transmission aggregometry demonstrated that, in ID, platelet aggregation was enhanced as reflected by the significantly higher area under the aggregometry curve (C; n=8 per group).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4114532&req=5

ajh23682-fig-0002:  Iron deficiency induces thrombocytosis and enhances platelet aggregation. Development of ID was paralleled by a rise in platelet counts (A) and an increase in MPV (B; n=4 per group). Light transmission aggregometry demonstrated that, in ID, platelet aggregation was enhanced as reflected by the significantly higher area under the aggregometry curve (C; n=8 per group).
Mentions: In parallel, platelet counts increased after week 1 and reached a plateau at week 4. The mean platelet count across all time points was 1445 ± 276 G L−1 vs. 976 ± 97 G L−1 (ID vs. controls; P < 0.001) (Fig. 2A). The mean platelet volume (MPV) increased in the ID group with a mean of 11.2 fL compared to 9.5 fL in controls (P = 0.004, Fig. 2B). Light transmission aggregometry after stimulation with ADP demonstrated a considerably larger AUC in ID (P = 0.001 by ANOVA; Fig. 2C).

Bottom Line: Moreover, platelets produced in iron deficient animals displayed a higher mean platelet volume and increased aggregation.Iron deficiency did not alter the production of hematopoietic growth factors such as thrombopoietin, interleukin 6 or interleukin 11.Megakaryocytic cell lines grown in iron-depleted conditions exhibited reduced proliferation but increased ploidy and cell size.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory on Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria.

Show MeSH
Related in: MedlinePlus