Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women.
Bottom Line: During a median follow-up of 10 years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code).This association attenuated towards the after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55).No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19).
Affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.Show MeSH
Related in: MedlinePlus
Mentions: Job strain at baseline was associated with an increased risk of severe asthma exacerbations in the age‐ and sex‐adjusted analyses with the outcome definition based on the primary diagnostic code (HR: 1.27, 95% CI: 1.00, 1.61) (Fig. 1) However, with additional adjustment for socioeconomic position, BMI, smoking and alcohol intake, this association attenuated towards the (HR: 1.22, 95% CI: 0.96, 1.55) (Fig. 2). Job strain was not associated with severe asthma exacerbations defined as any diagnostic code in the age‐ and sex‐adjusted analyses (HR: 1.07, 95% CI: 0.91, 1.25) or multivariable‐adjusted analyses (HR: 1.01, 95% CI: 0.86, 1.19) (Figs 1 and 2). There was little heterogeneity among the study‐specific estimates.
Affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.