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Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women.

Heikkilä K, Madsen IE, Nyberg ST, Fransson EI, Westerlund H, Westerholm PJ, Virtanen M, Vahtera J, Väänänen A, Theorell T, Suominen SB, Shipley MJ, Salo P, Rugulies R, Pentti J, Pejtersen JH, Oksanen T, Nordin M, Nielsen ML, Kouvonen A, Koskinen A, Koskenvuo M, Knutsson A, Ferrie JE, Dragano N, Burr H, Borritz M, Bjorner JB, Alfredsson L, Batty GD, Singh-Manoux A, Kivimäki M, IPD-Work Consorti - Allergy (2014)

Bottom Line: During a median follow-up of 10 years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code).This association attenuated towards the after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55).No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19).

View Article: PubMed Central - PubMed

Affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.

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Related in: MedlinePlus

Multivariable‐adjusted *association between job strain and severe asthma exacerbations.
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all12381-fig-0002: Multivariable‐adjusted *association between job strain and severe asthma exacerbations.

Mentions: Job strain at baseline was associated with an increased risk of severe asthma exacerbations in the age‐ and sex‐adjusted analyses with the outcome definition based on the primary diagnostic code (HR: 1.27, 95% CI: 1.00, 1.61) (Fig. 1) However, with additional adjustment for socioeconomic position, BMI, smoking and alcohol intake, this association attenuated towards the (HR: 1.22, 95% CI: 0.96, 1.55) (Fig. 2). Job strain was not associated with severe asthma exacerbations defined as any diagnostic code in the age‐ and sex‐adjusted analyses (HR: 1.07, 95% CI: 0.91, 1.25) or multivariable‐adjusted analyses (HR: 1.01, 95% CI: 0.86, 1.19) (Figs 1 and 2). There was little heterogeneity among the study‐specific estimates.


Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women.

Heikkilä K, Madsen IE, Nyberg ST, Fransson EI, Westerlund H, Westerholm PJ, Virtanen M, Vahtera J, Väänänen A, Theorell T, Suominen SB, Shipley MJ, Salo P, Rugulies R, Pentti J, Pejtersen JH, Oksanen T, Nordin M, Nielsen ML, Kouvonen A, Koskinen A, Koskenvuo M, Knutsson A, Ferrie JE, Dragano N, Burr H, Borritz M, Bjorner JB, Alfredsson L, Batty GD, Singh-Manoux A, Kivimäki M, IPD-Work Consorti - Allergy (2014)

Multivariable‐adjusted *association between job strain and severe asthma exacerbations.
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4114530&req=5

all12381-fig-0002: Multivariable‐adjusted *association between job strain and severe asthma exacerbations.
Mentions: Job strain at baseline was associated with an increased risk of severe asthma exacerbations in the age‐ and sex‐adjusted analyses with the outcome definition based on the primary diagnostic code (HR: 1.27, 95% CI: 1.00, 1.61) (Fig. 1) However, with additional adjustment for socioeconomic position, BMI, smoking and alcohol intake, this association attenuated towards the (HR: 1.22, 95% CI: 0.96, 1.55) (Fig. 2). Job strain was not associated with severe asthma exacerbations defined as any diagnostic code in the age‐ and sex‐adjusted analyses (HR: 1.07, 95% CI: 0.91, 1.25) or multivariable‐adjusted analyses (HR: 1.01, 95% CI: 0.86, 1.19) (Figs 1 and 2). There was little heterogeneity among the study‐specific estimates.

Bottom Line: During a median follow-up of 10 years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code).This association attenuated towards the after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55).No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19).

View Article: PubMed Central - PubMed

Affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.

Show MeSH
Related in: MedlinePlus