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Addressing nutritional gaps with multivitamin and mineral supplements.

Ward E - Nutr J (2014)

Bottom Line: In addition to the utility of MVMs for filling in relatively small but critical nutritional gaps, which may help prevent conditions such as anemia, neural tube defects, and osteoporosis, some evidence supports possible benefits of MVM supplementation with regard to cancer prevention (particularly in men) and prevention or delay of cataract, as well as some aspects of cognitive performance.Unlike some single-vitamin supplements, MVM supplements are generally well tolerated and do not appear to increase the risk of mortality, cerebrovascular disease, or heart failure.The potential benefits of MVM supplements likely outweigh any risk in the general population and may be particularly beneficial for older people.

View Article: PubMed Central - HTML - PubMed

Affiliation: 24 Oak Street, 01867 Reading, MA, USA. eward@ix.netcom.com.

ABSTRACT
A balanced and varied diet is the best source of essential vitamins and minerals; however, nutrient deficiencies occur, including in populations with bountiful food supplies and the means to procure nutrient-rich foods. For example, the typical American diet bears little resemblance to what experts recommend for fruit, vegetables, and whole grains, which serve as important sources of an array of vitamins and minerals. With time, deficiencies in one or more micronutrients may lead to serious health issues. A common reason people take multivitamin and mineral (MVM) supplements is to maintain or improve health, but research examining the effectiveness of MVMs in the prevention of certain chronic conditions is ongoing. In addition to the utility of MVMs for filling in relatively small but critical nutritional gaps, which may help prevent conditions such as anemia, neural tube defects, and osteoporosis, some evidence supports possible benefits of MVM supplementation with regard to cancer prevention (particularly in men) and prevention or delay of cataract, as well as some aspects of cognitive performance. Unlike some single-vitamin supplements, MVM supplements are generally well tolerated and do not appear to increase the risk of mortality, cerebrovascular disease, or heart failure. The potential benefits of MVM supplements likely outweigh any risk in the general population and may be particularly beneficial for older people.

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Related in: MedlinePlus

Physicians' Health Study II cumulative incidence of total cancer with MVM supplements vs placebo [16].
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Figure 1: Physicians' Health Study II cumulative incidence of total cancer with MVM supplements vs placebo [16].

Mentions: The recent PHS II was a large (N = 14,641), long-term (median 11.2 years follow-up) RCT of the MVM Centrum® Silver (Pfizer Consumer Healthcare) once daily in male physicians in the United States [16]. MVM supplementation was associated with a statistically significant 8% reduction in incidence of total cancer (P = .04; Figure 1). In addition, men with a history of cancer derived the most benefit from MVM supplementation, with a 27% lower incidence of new cancer versus placebo in this subgroup (P = .02). There was no effect on the risk of any specific individual cancer types due to a lack of statistical power, and there was a nonsignificant trend toward lower cancer-specific mortality (P = .07). Because the study was conducted with well-nourished male physicians, it is not known whether the results apply to other types of people, including women and those more likely to have dietary insufficiencies.


Addressing nutritional gaps with multivitamin and mineral supplements.

Ward E - Nutr J (2014)

Physicians' Health Study II cumulative incidence of total cancer with MVM supplements vs placebo [16].
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4109789&req=5

Figure 1: Physicians' Health Study II cumulative incidence of total cancer with MVM supplements vs placebo [16].
Mentions: The recent PHS II was a large (N = 14,641), long-term (median 11.2 years follow-up) RCT of the MVM Centrum® Silver (Pfizer Consumer Healthcare) once daily in male physicians in the United States [16]. MVM supplementation was associated with a statistically significant 8% reduction in incidence of total cancer (P = .04; Figure 1). In addition, men with a history of cancer derived the most benefit from MVM supplementation, with a 27% lower incidence of new cancer versus placebo in this subgroup (P = .02). There was no effect on the risk of any specific individual cancer types due to a lack of statistical power, and there was a nonsignificant trend toward lower cancer-specific mortality (P = .07). Because the study was conducted with well-nourished male physicians, it is not known whether the results apply to other types of people, including women and those more likely to have dietary insufficiencies.

Bottom Line: In addition to the utility of MVMs for filling in relatively small but critical nutritional gaps, which may help prevent conditions such as anemia, neural tube defects, and osteoporosis, some evidence supports possible benefits of MVM supplementation with regard to cancer prevention (particularly in men) and prevention or delay of cataract, as well as some aspects of cognitive performance.Unlike some single-vitamin supplements, MVM supplements are generally well tolerated and do not appear to increase the risk of mortality, cerebrovascular disease, or heart failure.The potential benefits of MVM supplements likely outweigh any risk in the general population and may be particularly beneficial for older people.

View Article: PubMed Central - HTML - PubMed

Affiliation: 24 Oak Street, 01867 Reading, MA, USA. eward@ix.netcom.com.

ABSTRACT
A balanced and varied diet is the best source of essential vitamins and minerals; however, nutrient deficiencies occur, including in populations with bountiful food supplies and the means to procure nutrient-rich foods. For example, the typical American diet bears little resemblance to what experts recommend for fruit, vegetables, and whole grains, which serve as important sources of an array of vitamins and minerals. With time, deficiencies in one or more micronutrients may lead to serious health issues. A common reason people take multivitamin and mineral (MVM) supplements is to maintain or improve health, but research examining the effectiveness of MVMs in the prevention of certain chronic conditions is ongoing. In addition to the utility of MVMs for filling in relatively small but critical nutritional gaps, which may help prevent conditions such as anemia, neural tube defects, and osteoporosis, some evidence supports possible benefits of MVM supplementation with regard to cancer prevention (particularly in men) and prevention or delay of cataract, as well as some aspects of cognitive performance. Unlike some single-vitamin supplements, MVM supplements are generally well tolerated and do not appear to increase the risk of mortality, cerebrovascular disease, or heart failure. The potential benefits of MVM supplements likely outweigh any risk in the general population and may be particularly beneficial for older people.

Show MeSH
Related in: MedlinePlus