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Compartmental modeling of whole-body vitamin A kinetics in unsupplemented and vitamin A-retinoic acid-supplemented neonatal rats.

Tan L, Wray AE, Green MH, Ross AC - J. Lipid Res. (2014)

Bottom Line: First, compartmental models for retinol kinetics were developed for individual tissues, and then an integrated compartmental model incorporating all tissues was developed for both groups.VARA increased CM retinyl ester uptake by lung, carcass, and intestine; decreased the release into plasma of retinol that had been cleared by liver and lung as CM retinyl esters; stimulated the uptake of retinol from plasma holo-retinol binding protein into carcass; and decreased the retinol turnover out of the liver.Overall, neonatal VA trafficking differed from that previously described for adult animals, with a larger contribution of extrahepatic tissues to CM clearance, especially after VA supplementation, and a significant amount of VA distributed in extrahepatic tissues.

View Article: PubMed Central - PubMed

Affiliation: Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802 Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802.

No MeSH data available.


Related in: MedlinePlus

Mean observed fraction of administered dose in liver (A) and lung (B) versus time (days) after administration of [3H]retinol in oil or in VARA to neonatal rats. Each point represents the mean of n = 3 pups.
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fig1: Mean observed fraction of administered dose in liver (A) and lung (B) versus time (days) after administration of [3H]retinol in oil or in VARA to neonatal rats. Each point represents the mean of n = 3 pups.

Mentions: Data on fraction of the dose remaining in liver and lung versus time after dose administration are plotted semilogarithmically in Fig. 1. In liver (Fig. 1A), radioactivity increased until 2 days after dosing in both groups. The maximum recovery of radioactivity from liver was 18% in control pups and 28% in VARA-treated pups. After 2 days postdosing, radioactivity in control neonates decreased gradually until the end of the study, while the fraction of dose remained relatively constant in VARA-treated neonates. Except for values 4 days postdosing, the mean fraction of the dose in liver was higher in VARA-treated pups than in control pups.


Compartmental modeling of whole-body vitamin A kinetics in unsupplemented and vitamin A-retinoic acid-supplemented neonatal rats.

Tan L, Wray AE, Green MH, Ross AC - J. Lipid Res. (2014)

Mean observed fraction of administered dose in liver (A) and lung (B) versus time (days) after administration of [3H]retinol in oil or in VARA to neonatal rats. Each point represents the mean of n = 3 pups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109768&req=5

fig1: Mean observed fraction of administered dose in liver (A) and lung (B) versus time (days) after administration of [3H]retinol in oil or in VARA to neonatal rats. Each point represents the mean of n = 3 pups.
Mentions: Data on fraction of the dose remaining in liver and lung versus time after dose administration are plotted semilogarithmically in Fig. 1. In liver (Fig. 1A), radioactivity increased until 2 days after dosing in both groups. The maximum recovery of radioactivity from liver was 18% in control pups and 28% in VARA-treated pups. After 2 days postdosing, radioactivity in control neonates decreased gradually until the end of the study, while the fraction of dose remained relatively constant in VARA-treated neonates. Except for values 4 days postdosing, the mean fraction of the dose in liver was higher in VARA-treated pups than in control pups.

Bottom Line: First, compartmental models for retinol kinetics were developed for individual tissues, and then an integrated compartmental model incorporating all tissues was developed for both groups.VARA increased CM retinyl ester uptake by lung, carcass, and intestine; decreased the release into plasma of retinol that had been cleared by liver and lung as CM retinyl esters; stimulated the uptake of retinol from plasma holo-retinol binding protein into carcass; and decreased the retinol turnover out of the liver.Overall, neonatal VA trafficking differed from that previously described for adult animals, with a larger contribution of extrahepatic tissues to CM clearance, especially after VA supplementation, and a significant amount of VA distributed in extrahepatic tissues.

View Article: PubMed Central - PubMed

Affiliation: Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802 Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802.

No MeSH data available.


Related in: MedlinePlus