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Genetic evaluation of mesenchymal stem cells by G-banded karyotyping in a Cell Technology Center.

Borgonovo T, Vaz IM, Senegaglia AC, Rebelatto CL, Brofman PR - Rev Bras Hematol Hemoter (2014)

Bottom Line: To present the initial results of first three years of implementation of a genetic evaluation test for bone marrow-derived mesenchymal stem cells in a Cell Technology Center.All the samples analyzed, before and after cell expansion, had normal karyotypes, showing no clonal chromosomal changes.Signs of chromosomal instability were observed in 11 out of 21 patients (52%).

View Article: PubMed Central - PubMed

Affiliation: Pontifícia Universidade Católica do Paraná (PUC-PR), Curitiba, PR, Brazil. Electronic address: tamaraborgonovo@yahoo.com.br.

No MeSH data available.


Related in: MedlinePlus

Case 05; mesenchymal stem cells – Passage 1. Metaphase showing diplochromosome.
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fig0015: Case 05; mesenchymal stem cells – Passage 1. Metaphase showing diplochromosome.

Mentions: A small fraction of these cells showed diplochromosomes (Figure 3).


Genetic evaluation of mesenchymal stem cells by G-banded karyotyping in a Cell Technology Center.

Borgonovo T, Vaz IM, Senegaglia AC, Rebelatto CL, Brofman PR - Rev Bras Hematol Hemoter (2014)

Case 05; mesenchymal stem cells – Passage 1. Metaphase showing diplochromosome.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109748&req=5

fig0015: Case 05; mesenchymal stem cells – Passage 1. Metaphase showing diplochromosome.
Mentions: A small fraction of these cells showed diplochromosomes (Figure 3).

Bottom Line: To present the initial results of first three years of implementation of a genetic evaluation test for bone marrow-derived mesenchymal stem cells in a Cell Technology Center.All the samples analyzed, before and after cell expansion, had normal karyotypes, showing no clonal chromosomal changes.Signs of chromosomal instability were observed in 11 out of 21 patients (52%).

View Article: PubMed Central - PubMed

Affiliation: Pontifícia Universidade Católica do Paraná (PUC-PR), Curitiba, PR, Brazil. Electronic address: tamaraborgonovo@yahoo.com.br.

No MeSH data available.


Related in: MedlinePlus