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Systemic mastocytosis - a diagnostic challenge.

Lladó AC, Mihon CE, Silva M, Galzerano A - Rev Bras Hematol Hemoter (2014)

Bottom Line: The histopathologic analysis is essential for definitive diagnosis but there is no curative treatment.This is a rare clinical case of aggressive systemic mastocytosis for which palliative treatment can improve survival and quality of life.A brief review of the literature about this pathology is also included.

View Article: PubMed Central - PubMed

Affiliation: Hospital Santo António dos Capuchos, Lisbon, Portugal; Centro Hospitalar de Lisboa Central, Lisbon, Portugal. Electronic address: ana.llado@sapo.pt.

No MeSH data available.


Related in: MedlinePlus

Computed tomography scan of the lumbar spine and sacrum – osteosclerotic and osteolytic lesions, without expansive features, spread throughout the axial skeleton (sagittal view).
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fig0010: Computed tomography scan of the lumbar spine and sacrum – osteosclerotic and osteolytic lesions, without expansive features, spread throughout the axial skeleton (sagittal view).

Mentions: Several medical tests were performed including blood analysis, endoscopic and imaging exams but none showed relevant changes. In September she started with persistent diaphoresis with no fever or any symptoms suggestive of an infectious focus, anorexia and a quantified weight loss. The blood tests revealed slightly elevated levels of alkaline phosphatase (162 U/L) and lactate dehydrogenase (LDH – 454 U/L). She was admitted again and a CT body scan was performed (Figure 2) which showed osteolytic lesions, in addition to the diffuse osteosclerotic lesions previously documented, without expansive features, spread throughout the axial skeleton, that were assumed to be bone marrow sclerosis phenomena. Diaphoresis was associated to a pharmacological iatrogenic effect and the weight loss to a reactive depression. She was discharged and referred to our Internal Medicine Department.


Systemic mastocytosis - a diagnostic challenge.

Lladó AC, Mihon CE, Silva M, Galzerano A - Rev Bras Hematol Hemoter (2014)

Computed tomography scan of the lumbar spine and sacrum – osteosclerotic and osteolytic lesions, without expansive features, spread throughout the axial skeleton (sagittal view).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109736&req=5

fig0010: Computed tomography scan of the lumbar spine and sacrum – osteosclerotic and osteolytic lesions, without expansive features, spread throughout the axial skeleton (sagittal view).
Mentions: Several medical tests were performed including blood analysis, endoscopic and imaging exams but none showed relevant changes. In September she started with persistent diaphoresis with no fever or any symptoms suggestive of an infectious focus, anorexia and a quantified weight loss. The blood tests revealed slightly elevated levels of alkaline phosphatase (162 U/L) and lactate dehydrogenase (LDH – 454 U/L). She was admitted again and a CT body scan was performed (Figure 2) which showed osteolytic lesions, in addition to the diffuse osteosclerotic lesions previously documented, without expansive features, spread throughout the axial skeleton, that were assumed to be bone marrow sclerosis phenomena. Diaphoresis was associated to a pharmacological iatrogenic effect and the weight loss to a reactive depression. She was discharged and referred to our Internal Medicine Department.

Bottom Line: The histopathologic analysis is essential for definitive diagnosis but there is no curative treatment.This is a rare clinical case of aggressive systemic mastocytosis for which palliative treatment can improve survival and quality of life.A brief review of the literature about this pathology is also included.

View Article: PubMed Central - PubMed

Affiliation: Hospital Santo António dos Capuchos, Lisbon, Portugal; Centro Hospitalar de Lisboa Central, Lisbon, Portugal. Electronic address: ana.llado@sapo.pt.

No MeSH data available.


Related in: MedlinePlus