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Tumor suppressor p53 protein expression: prognostic significance in patients with low-risk myelodysplastic syndrome.

Duarte FB, Gonçalves RP, Barbosa MC, Rocha Filho FD, de Jesus Dos Santos TE, Dos Santos TN, de Vasconcelos PR - Rev Bras Hematol Hemoter (2014)

Bottom Line: However, these patients often show very variable clinical outcomes.At diagnosis, this group of patients also presented clinical features characteristic of a poor prognosis more often than patients who did not express p53.Furthermore, patients expressing p53 had a shorter median survival time compared to those without p53 expression.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.

No MeSH data available.


Related in: MedlinePlus

Influence of the p53 expression on the reticulin and bone marrow iron in myelodysplastic patients at diagnosis.
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fig0010: Influence of the p53 expression on the reticulin and bone marrow iron in myelodysplastic patients at diagnosis.

Mentions: Figure 2 shows p53 expression in relation to reticulin, a marker for fibrosis, and bone marrow iron in the sample. Patients with p53 expression had a higher frequency of more advanced fibrosis levels (II/III) at diagnosis (46.15%), while the patients without p53 expression showed a significantly lower frequency (12%; p-value = 0.041). Furthermore, patients with p53 expression also showed higher bone marrow iron at diagnosis compared to patients without p53 expression (27.3% versus 5.5%, respectively). While this observation was not statistically significant, there was a marked tendency for bone marrow iron to be higher when p53 was expressed.


Tumor suppressor p53 protein expression: prognostic significance in patients with low-risk myelodysplastic syndrome.

Duarte FB, Gonçalves RP, Barbosa MC, Rocha Filho FD, de Jesus Dos Santos TE, Dos Santos TN, de Vasconcelos PR - Rev Bras Hematol Hemoter (2014)

Influence of the p53 expression on the reticulin and bone marrow iron in myelodysplastic patients at diagnosis.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109734&req=5

fig0010: Influence of the p53 expression on the reticulin and bone marrow iron in myelodysplastic patients at diagnosis.
Mentions: Figure 2 shows p53 expression in relation to reticulin, a marker for fibrosis, and bone marrow iron in the sample. Patients with p53 expression had a higher frequency of more advanced fibrosis levels (II/III) at diagnosis (46.15%), while the patients without p53 expression showed a significantly lower frequency (12%; p-value = 0.041). Furthermore, patients with p53 expression also showed higher bone marrow iron at diagnosis compared to patients without p53 expression (27.3% versus 5.5%, respectively). While this observation was not statistically significant, there was a marked tendency for bone marrow iron to be higher when p53 was expressed.

Bottom Line: However, these patients often show very variable clinical outcomes.At diagnosis, this group of patients also presented clinical features characteristic of a poor prognosis more often than patients who did not express p53.Furthermore, patients expressing p53 had a shorter median survival time compared to those without p53 expression.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.

No MeSH data available.


Related in: MedlinePlus