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fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.

Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A - Neuroimage Clin (2014)

Bottom Line: After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05).After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability.The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

View Article: PubMed Central - PubMed

Affiliation: Yoshida Eye Clinic, 9 Higashi-honncho, Shimogamo, Sakyo-ku, Kyoto 606-0863, Japan.

ABSTRACT
To evaluate changes in the visual processing of patients with progressive retinitis pigmentosa (RP) who acquired improved reading capability by eye-movement training (EMT), we performed functional magnetic resonance imaging (fMRI) before and after EMT. Six patients with bilateral concentric contraction caused by pigmentary degeneration of the retina and 6 normal volunteers were recruited. Patients were given EMT for 5 min every day for 8-10 months. fMRI data were acquired on a 3.0-Tesla scanner while subjects were performing reading tasks. In separate experiments (before fMRI scanning), visual performances for readings were measured by the number of letters read correctly in 5 min. Before EMT, activation areas of the primary visual cortex of patients were 48.8% of those of the controls. The number of letters read correctly in 5 min was 36.6% of those by the normal volunteers. After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05). After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability. The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

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Related in: MedlinePlus

Activation maps during the fMRI task (TANKA tasks) of a normal volunteer (N) (top: typical example) and individual patients (only the number is shown) before eye- movement training (EMT). Axial slice at z = + 55 is focusing on the superior parietal lobule (SPL), inferior parietal lobule (IPL), supplementary motor area (SMA), supple- mentary eye fields (SEFs), FEF, dorsolateral prefrontal cortex (DLPFC), and primary motor area (M1). Axial slice at z = + 35 is focusing on those areas except for SMA and SEFs. Activations of the V3 and those of V1/V2 and medial temporal lobule (V5 / MT) can be observed in the slice at z = + 25 and z = + 5 and − 15, respectively.
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f0015: Activation maps during the fMRI task (TANKA tasks) of a normal volunteer (N) (top: typical example) and individual patients (only the number is shown) before eye- movement training (EMT). Axial slice at z = + 55 is focusing on the superior parietal lobule (SPL), inferior parietal lobule (IPL), supplementary motor area (SMA), supple- mentary eye fields (SEFs), FEF, dorsolateral prefrontal cortex (DLPFC), and primary motor area (M1). Axial slice at z = + 35 is focusing on those areas except for SMA and SEFs. Activations of the V3 and those of V1/V2 and medial temporal lobule (V5 / MT) can be observed in the slice at z = + 25 and z = + 5 and − 15, respectively.

Mentions: Fig. 3 shows brain activation during the fMRI tasks (Kana tasks minus rest contrast) before EMT. To visualize the effect of EMT on neural activation, cognitive subtractions before and after EMT of individual patients are shown in Fig. 4. Activations of the V3 (in the axial slice at z= +25) and V1/V2 and medial temporal lobule (V5/MT) (in the slices at z= +5 and −15) could be observed in Figs. 3 and 4. Increases in activities of both V3 and V5/MT areas were observed after EMT in all patients, in spite of individual differences (Fig. 4).


fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.

Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A - Neuroimage Clin (2014)

Activation maps during the fMRI task (TANKA tasks) of a normal volunteer (N) (top: typical example) and individual patients (only the number is shown) before eye- movement training (EMT). Axial slice at z = + 55 is focusing on the superior parietal lobule (SPL), inferior parietal lobule (IPL), supplementary motor area (SMA), supple- mentary eye fields (SEFs), FEF, dorsolateral prefrontal cortex (DLPFC), and primary motor area (M1). Axial slice at z = + 35 is focusing on those areas except for SMA and SEFs. Activations of the V3 and those of V1/V2 and medial temporal lobule (V5 / MT) can be observed in the slice at z = + 25 and z = + 5 and − 15, respectively.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109700&req=5

f0015: Activation maps during the fMRI task (TANKA tasks) of a normal volunteer (N) (top: typical example) and individual patients (only the number is shown) before eye- movement training (EMT). Axial slice at z = + 55 is focusing on the superior parietal lobule (SPL), inferior parietal lobule (IPL), supplementary motor area (SMA), supple- mentary eye fields (SEFs), FEF, dorsolateral prefrontal cortex (DLPFC), and primary motor area (M1). Axial slice at z = + 35 is focusing on those areas except for SMA and SEFs. Activations of the V3 and those of V1/V2 and medial temporal lobule (V5 / MT) can be observed in the slice at z = + 25 and z = + 5 and − 15, respectively.
Mentions: Fig. 3 shows brain activation during the fMRI tasks (Kana tasks minus rest contrast) before EMT. To visualize the effect of EMT on neural activation, cognitive subtractions before and after EMT of individual patients are shown in Fig. 4. Activations of the V3 (in the axial slice at z= +25) and V1/V2 and medial temporal lobule (V5/MT) (in the slices at z= +5 and −15) could be observed in Figs. 3 and 4. Increases in activities of both V3 and V5/MT areas were observed after EMT in all patients, in spite of individual differences (Fig. 4).

Bottom Line: After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05).After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability.The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

View Article: PubMed Central - PubMed

Affiliation: Yoshida Eye Clinic, 9 Higashi-honncho, Shimogamo, Sakyo-ku, Kyoto 606-0863, Japan.

ABSTRACT
To evaluate changes in the visual processing of patients with progressive retinitis pigmentosa (RP) who acquired improved reading capability by eye-movement training (EMT), we performed functional magnetic resonance imaging (fMRI) before and after EMT. Six patients with bilateral concentric contraction caused by pigmentary degeneration of the retina and 6 normal volunteers were recruited. Patients were given EMT for 5 min every day for 8-10 months. fMRI data were acquired on a 3.0-Tesla scanner while subjects were performing reading tasks. In separate experiments (before fMRI scanning), visual performances for readings were measured by the number of letters read correctly in 5 min. Before EMT, activation areas of the primary visual cortex of patients were 48.8% of those of the controls. The number of letters read correctly in 5 min was 36.6% of those by the normal volunteers. After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05). After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability. The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

Show MeSH
Related in: MedlinePlus