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fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.

Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A - Neuroimage Clin (2014)

Bottom Line: After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05).After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability.The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

View Article: PubMed Central - PubMed

Affiliation: Yoshida Eye Clinic, 9 Higashi-honncho, Shimogamo, Sakyo-ku, Kyoto 606-0863, Japan.

ABSTRACT
To evaluate changes in the visual processing of patients with progressive retinitis pigmentosa (RP) who acquired improved reading capability by eye-movement training (EMT), we performed functional magnetic resonance imaging (fMRI) before and after EMT. Six patients with bilateral concentric contraction caused by pigmentary degeneration of the retina and 6 normal volunteers were recruited. Patients were given EMT for 5 min every day for 8-10 months. fMRI data were acquired on a 3.0-Tesla scanner while subjects were performing reading tasks. In separate experiments (before fMRI scanning), visual performances for readings were measured by the number of letters read correctly in 5 min. Before EMT, activation areas of the primary visual cortex of patients were 48.8% of those of the controls. The number of letters read correctly in 5 min was 36.6% of those by the normal volunteers. After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05). After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability. The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

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A: Examples of activation maps during the fMRI task (TANKA tasks) of a normal volunteer (left) and a patient with concentric contraction before (middle) and after (right) eye-movement training (EMT). Top, sagittal slice at x = 10 (MNI). Bottom, axial slice at z = – 8 (MNI). B: Number of activation voxels in the primary visual cortex along the calcarine sulcus. Data are shown as mean ± SE. Normal volunteers (Normal) (n = 6) vs. patients (n = 6), unpaired Welch’s t-test ( + +, p < 0.01). P (pre) vs. P (post), paired t -test. NS denotes no significance..
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f0010: A: Examples of activation maps during the fMRI task (TANKA tasks) of a normal volunteer (left) and a patient with concentric contraction before (middle) and after (right) eye-movement training (EMT). Top, sagittal slice at x = 10 (MNI). Bottom, axial slice at z = – 8 (MNI). B: Number of activation voxels in the primary visual cortex along the calcarine sulcus. Data are shown as mean ± SE. Normal volunteers (Normal) (n = 6) vs. patients (n = 6), unpaired Welch’s t-test ( + +, p < 0.01). P (pre) vs. P (post), paired t -test. NS denotes no significance..

Mentions: Fig. 2A shows examples of the activation areas for the normal volunteers (left) and those for patients before (middle) and after (right) EMT, as measured by fMRI during the fMRI task. Activated areas of the visual cortices (mainly V1 and V2) in patients were noticeably decreased post-EMT. This result indicates that the impairment in visual information transfer from the retina to the primary visual cortex (V1) was progressing. Fig. 2B shows the results of statistical analyses of the volume size of the activation area along the calcarine sulcus. The activation areas of the visual cortex before and after EMT were fewer in patients (n= 6) than in the normal volunteers (<52% on average, p< 0.01). Furthermore, their volume/size after EMT showed a tendency to decrease as compared with that before EMT; however, the difference was not significant (p= 0.280), although the activation area of the visual cortex in some patients decreased markedly (see Supplementary Fig. 3).


fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.

Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A - Neuroimage Clin (2014)

A: Examples of activation maps during the fMRI task (TANKA tasks) of a normal volunteer (left) and a patient with concentric contraction before (middle) and after (right) eye-movement training (EMT). Top, sagittal slice at x = 10 (MNI). Bottom, axial slice at z = – 8 (MNI). B: Number of activation voxels in the primary visual cortex along the calcarine sulcus. Data are shown as mean ± SE. Normal volunteers (Normal) (n = 6) vs. patients (n = 6), unpaired Welch’s t-test ( + +, p < 0.01). P (pre) vs. P (post), paired t -test. NS denotes no significance..
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

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Show All Figures
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f0010: A: Examples of activation maps during the fMRI task (TANKA tasks) of a normal volunteer (left) and a patient with concentric contraction before (middle) and after (right) eye-movement training (EMT). Top, sagittal slice at x = 10 (MNI). Bottom, axial slice at z = – 8 (MNI). B: Number of activation voxels in the primary visual cortex along the calcarine sulcus. Data are shown as mean ± SE. Normal volunteers (Normal) (n = 6) vs. patients (n = 6), unpaired Welch’s t-test ( + +, p < 0.01). P (pre) vs. P (post), paired t -test. NS denotes no significance..
Mentions: Fig. 2A shows examples of the activation areas for the normal volunteers (left) and those for patients before (middle) and after (right) EMT, as measured by fMRI during the fMRI task. Activated areas of the visual cortices (mainly V1 and V2) in patients were noticeably decreased post-EMT. This result indicates that the impairment in visual information transfer from the retina to the primary visual cortex (V1) was progressing. Fig. 2B shows the results of statistical analyses of the volume size of the activation area along the calcarine sulcus. The activation areas of the visual cortex before and after EMT were fewer in patients (n= 6) than in the normal volunteers (<52% on average, p< 0.01). Furthermore, their volume/size after EMT showed a tendency to decrease as compared with that before EMT; however, the difference was not significant (p= 0.280), although the activation area of the visual cortex in some patients decreased markedly (see Supplementary Fig. 3).

Bottom Line: After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05).After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability.The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

View Article: PubMed Central - PubMed

Affiliation: Yoshida Eye Clinic, 9 Higashi-honncho, Shimogamo, Sakyo-ku, Kyoto 606-0863, Japan.

ABSTRACT
To evaluate changes in the visual processing of patients with progressive retinitis pigmentosa (RP) who acquired improved reading capability by eye-movement training (EMT), we performed functional magnetic resonance imaging (fMRI) before and after EMT. Six patients with bilateral concentric contraction caused by pigmentary degeneration of the retina and 6 normal volunteers were recruited. Patients were given EMT for 5 min every day for 8-10 months. fMRI data were acquired on a 3.0-Tesla scanner while subjects were performing reading tasks. In separate experiments (before fMRI scanning), visual performances for readings were measured by the number of letters read correctly in 5 min. Before EMT, activation areas of the primary visual cortex of patients were 48.8% of those of the controls. The number of letters read correctly in 5 min was 36.6% of those by the normal volunteers. After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05). After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability. The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements.

Show MeSH
Related in: MedlinePlus