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Small RNAs in mycobacteria: an unfolding story.

Haning K, Cho SH, Contreras LM - Front Cell Infect Microbiol (2014)

Bottom Line: Mycobacteria represent a class of powerful pathogens, including those causing tuberculosis and leprosy, which continue to be worldwide health challenges.Characterization of these sRNAs is only beginning, but differential expression under environmental stresses suggests relevance to mycobacterial pathogenesis.This review provides a comprehensive overview of the current knowledge of sRNAs in mycobacteria, including historical perspective and techniques used for identification and characterization.

View Article: PubMed Central - PubMed

Affiliation: McKetta Department of Chemical Engineering, Cockrell School of Engineering, The University of Texas at Austin Austin, TX, USA.

ABSTRACT
Mycobacteria represent a class of powerful pathogens, including those causing tuberculosis and leprosy, which continue to be worldwide health challenges. In the last 20 years, an abundance of non-coding, small RNAs (sRNAs) have been discovered in model bacteria and gained significant attention as regulators of cellular responses, including pathogenesis. Naturally, a search in mycobacteria followed, revealing over 200 sRNAs thus far. Characterization of these sRNAs is only beginning, but differential expression under environmental stresses suggests relevance to mycobacterial pathogenesis. This review provides a comprehensive overview of the current knowledge of sRNAs in mycobacteria, including historical perspective and techniques used for identification and characterization.

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Related in: MedlinePlus

Timeline of sRNA developments in mycobacteria. Progress in M. tuberculosis (upper) and other mycobacterial species (lower) are shown in parallel in chronological order. The surge of studies in the last few years suggests momentum toward further discovery, mechanistic studies, and medical applications.
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Figure 3: Timeline of sRNA developments in mycobacteria. Progress in M. tuberculosis (upper) and other mycobacterial species (lower) are shown in parallel in chronological order. The surge of studies in the last few years suggests momentum toward further discovery, mechanistic studies, and medical applications.

Mentions: As we unfold major themes of the sRNA story in mycobacteria, refer to Figure 3 for the chronological alignment of these events. Also, note that Supplementary Table S1 lists all confirmed sRNAs in mycobacterial species to date along with characteristic data such as genomic location, differential expression, and known homology between species. Amazingly, more than half of the M. tuberculosis H37Rv sRNAs have been confirmed since the most recent sRNA review of this species (Arnvig and Young, 2012). Unconfirmed sRNA predictions are not included in Supplementary Table S1, but are quantified in Figure 1, a view of sRNA discovery by phylogeny within mycobacterial species, and listed in Supplementary Table S2. We use a universal sRNA nomenclature reported in Lamichhane et al. (2013) throughout this review to allow convenient cross-reference among the sRNAs being discussed.


Small RNAs in mycobacteria: an unfolding story.

Haning K, Cho SH, Contreras LM - Front Cell Infect Microbiol (2014)

Timeline of sRNA developments in mycobacteria. Progress in M. tuberculosis (upper) and other mycobacterial species (lower) are shown in parallel in chronological order. The surge of studies in the last few years suggests momentum toward further discovery, mechanistic studies, and medical applications.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109619&req=5

Figure 3: Timeline of sRNA developments in mycobacteria. Progress in M. tuberculosis (upper) and other mycobacterial species (lower) are shown in parallel in chronological order. The surge of studies in the last few years suggests momentum toward further discovery, mechanistic studies, and medical applications.
Mentions: As we unfold major themes of the sRNA story in mycobacteria, refer to Figure 3 for the chronological alignment of these events. Also, note that Supplementary Table S1 lists all confirmed sRNAs in mycobacterial species to date along with characteristic data such as genomic location, differential expression, and known homology between species. Amazingly, more than half of the M. tuberculosis H37Rv sRNAs have been confirmed since the most recent sRNA review of this species (Arnvig and Young, 2012). Unconfirmed sRNA predictions are not included in Supplementary Table S1, but are quantified in Figure 1, a view of sRNA discovery by phylogeny within mycobacterial species, and listed in Supplementary Table S2. We use a universal sRNA nomenclature reported in Lamichhane et al. (2013) throughout this review to allow convenient cross-reference among the sRNAs being discussed.

Bottom Line: Mycobacteria represent a class of powerful pathogens, including those causing tuberculosis and leprosy, which continue to be worldwide health challenges.Characterization of these sRNAs is only beginning, but differential expression under environmental stresses suggests relevance to mycobacterial pathogenesis.This review provides a comprehensive overview of the current knowledge of sRNAs in mycobacteria, including historical perspective and techniques used for identification and characterization.

View Article: PubMed Central - PubMed

Affiliation: McKetta Department of Chemical Engineering, Cockrell School of Engineering, The University of Texas at Austin Austin, TX, USA.

ABSTRACT
Mycobacteria represent a class of powerful pathogens, including those causing tuberculosis and leprosy, which continue to be worldwide health challenges. In the last 20 years, an abundance of non-coding, small RNAs (sRNAs) have been discovered in model bacteria and gained significant attention as regulators of cellular responses, including pathogenesis. Naturally, a search in mycobacteria followed, revealing over 200 sRNAs thus far. Characterization of these sRNAs is only beginning, but differential expression under environmental stresses suggests relevance to mycobacterial pathogenesis. This review provides a comprehensive overview of the current knowledge of sRNAs in mycobacteria, including historical perspective and techniques used for identification and characterization.

Show MeSH
Related in: MedlinePlus