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Stereotactic body radiotherapy for small lung tumors in the University of Tokyo Hospital.

Yamashita H, Takahashi W, Haga A, Kida S, Saotome N, Nakagawa K - Biomed Res Int (2014)

Bottom Line: Our work on stereotactic body radiation therapy (SBRT) for primary and metastatic lung tumors will be described.The eligibility criteria for SBRT, our previous SBRT method, the definition of target volume, heterogeneity correction, the position adjustment using four-dimensional cone-beam computed tomography (4D CBCT) immediately before SBRT, volumetric modulated arc therapy (VMAT) method for SBRT, verifying of tumor position within internal target volume (ITV) using in-treatment 4D-CBCT during VMAT-SBRT, shortening of treatment time using flattening-filter-free (FFF) techniques, delivery of 4D dose calculation for lung-VMAT patients using in-treatment CBCT and LINAC log data with agility multileaf collimator, and SBRT method for centrally located lung tumors in our institution will be shown.In our institution, these efforts have been made with the goal of raising the local control rate and decreasing adverse effects after SBRT.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

ABSTRACT
Our work on stereotactic body radiation therapy (SBRT) for primary and metastatic lung tumors will be described. The eligibility criteria for SBRT, our previous SBRT method, the definition of target volume, heterogeneity correction, the position adjustment using four-dimensional cone-beam computed tomography (4D CBCT) immediately before SBRT, volumetric modulated arc therapy (VMAT) method for SBRT, verifying of tumor position within internal target volume (ITV) using in-treatment 4D-CBCT during VMAT-SBRT, shortening of treatment time using flattening-filter-free (FFF) techniques, delivery of 4D dose calculation for lung-VMAT patients using in-treatment CBCT and LINAC log data with agility multileaf collimator, and SBRT method for centrally located lung tumors in our institution will be shown. In our institution, these efforts have been made with the goal of raising the local control rate and decreasing adverse effects after SBRT.

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CBCT images (axial view) for a moving phantom (QUASAR; Modus Medical Devices, Inc.): (a) 3D (2 minutes per rotation), (b) 4D (4 minutes per rotation), (c) 4D (2 minutes per rotation), and (d) 4D (1 minute per rotation) images.
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fig4: CBCT images (axial view) for a moving phantom (QUASAR; Modus Medical Devices, Inc.): (a) 3D (2 minutes per rotation), (b) 4D (4 minutes per rotation), (c) 4D (2 minutes per rotation), and (d) 4D (1 minute per rotation) images.

Mentions: The space-time information of a tumor location from the clear images of 4D CBCT would play an important role in the delivery of precise radiation therapy. However, it should be noted that the slower gantry speed in 4D CBCT imaging could add a significant radiation dose to the patient. Therefore, it would be desirable to optimize radiation parameters to reduce the imaging dose as low as reasonably achievable. The mA per frame and ms per frame are 20 mA/frame and 40 ms/frame, which are used clinically in the University of Tokyo Hospital (Figure 4). With those parameters, the CT dose index (CTDI) volume is approximately 12 mGy for 4D CBCT imaging with 4 minutes per rotation, measured with a 15 cm length CTDI phantom.


Stereotactic body radiotherapy for small lung tumors in the University of Tokyo Hospital.

Yamashita H, Takahashi W, Haga A, Kida S, Saotome N, Nakagawa K - Biomed Res Int (2014)

CBCT images (axial view) for a moving phantom (QUASAR; Modus Medical Devices, Inc.): (a) 3D (2 minutes per rotation), (b) 4D (4 minutes per rotation), (c) 4D (2 minutes per rotation), and (d) 4D (1 minute per rotation) images.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109604&req=5

fig4: CBCT images (axial view) for a moving phantom (QUASAR; Modus Medical Devices, Inc.): (a) 3D (2 minutes per rotation), (b) 4D (4 minutes per rotation), (c) 4D (2 minutes per rotation), and (d) 4D (1 minute per rotation) images.
Mentions: The space-time information of a tumor location from the clear images of 4D CBCT would play an important role in the delivery of precise radiation therapy. However, it should be noted that the slower gantry speed in 4D CBCT imaging could add a significant radiation dose to the patient. Therefore, it would be desirable to optimize radiation parameters to reduce the imaging dose as low as reasonably achievable. The mA per frame and ms per frame are 20 mA/frame and 40 ms/frame, which are used clinically in the University of Tokyo Hospital (Figure 4). With those parameters, the CT dose index (CTDI) volume is approximately 12 mGy for 4D CBCT imaging with 4 minutes per rotation, measured with a 15 cm length CTDI phantom.

Bottom Line: Our work on stereotactic body radiation therapy (SBRT) for primary and metastatic lung tumors will be described.The eligibility criteria for SBRT, our previous SBRT method, the definition of target volume, heterogeneity correction, the position adjustment using four-dimensional cone-beam computed tomography (4D CBCT) immediately before SBRT, volumetric modulated arc therapy (VMAT) method for SBRT, verifying of tumor position within internal target volume (ITV) using in-treatment 4D-CBCT during VMAT-SBRT, shortening of treatment time using flattening-filter-free (FFF) techniques, delivery of 4D dose calculation for lung-VMAT patients using in-treatment CBCT and LINAC log data with agility multileaf collimator, and SBRT method for centrally located lung tumors in our institution will be shown.In our institution, these efforts have been made with the goal of raising the local control rate and decreasing adverse effects after SBRT.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

ABSTRACT
Our work on stereotactic body radiation therapy (SBRT) for primary and metastatic lung tumors will be described. The eligibility criteria for SBRT, our previous SBRT method, the definition of target volume, heterogeneity correction, the position adjustment using four-dimensional cone-beam computed tomography (4D CBCT) immediately before SBRT, volumetric modulated arc therapy (VMAT) method for SBRT, verifying of tumor position within internal target volume (ITV) using in-treatment 4D-CBCT during VMAT-SBRT, shortening of treatment time using flattening-filter-free (FFF) techniques, delivery of 4D dose calculation for lung-VMAT patients using in-treatment CBCT and LINAC log data with agility multileaf collimator, and SBRT method for centrally located lung tumors in our institution will be shown. In our institution, these efforts have been made with the goal of raising the local control rate and decreasing adverse effects after SBRT.

Show MeSH
Related in: MedlinePlus