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Development and matching of binocular orientation preference in mouse V1.

Bhaumik B, Shah NP - Front Syst Neurosci (2014)

Bottom Line: At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective.The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells.It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

View Article: PubMed Central - PubMed

Affiliation: Electrical Engineering Department, Indian Institute of Technology Delhi New Delhi, India.

ABSTRACT
Eye-specific thalamic inputs converge in the primary visual cortex (V1) and form the basis of binocular vision. For normal binocular perceptions, such as depth and stereopsis, binocularly matched orientation preference between the two eyes is required. A critical period of binocular matching of orientation preference in mice during normal development is reported in literature. Using a reaction diffusion model we present the development of RF and orientation selectivity in mouse V1 and investigate the binocular orientation preference matching during the critical period. At the onset of the critical period the preferred orientations of the modeled cells are mostly mismatched in the two eyes and the mismatch decreases and reaches levels reported in juvenile mouse by the end of the critical period. At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective. In literature around 40% cortical cells are reported as orientation selective in mouse V1. The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells. The absence of near neighbor interaction among cortical cells during the development of thalamo-cortical wiring causes a salt and pepper organization in the orientation preference map in mice. It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

No MeSH data available.


Related in: MedlinePlus

(Ai–iii) Histogram of preferred orientation difference between the two eyes, ΔOR, at maturity (3000th epochs) for C-iter = 0, 500, and 1500 for cells from the same 35 × 60 patch of cortex used for Figure 7. (iv) The cumulative distribution of ΔOR, at 3000 epochs is shown for three different values of C-iter. The green line depicts uniform distribution. (B) The HWHH histograms for binocular oriented cells from the same patch of cells as in (A) for (i) C-iter = 0, (ii) C-iter = 500, and (iii) C-iter = 1500.
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Figure 8: (Ai–iii) Histogram of preferred orientation difference between the two eyes, ΔOR, at maturity (3000th epochs) for C-iter = 0, 500, and 1500 for cells from the same 35 × 60 patch of cortex used for Figure 7. (iv) The cumulative distribution of ΔOR, at 3000 epochs is shown for three different values of C-iter. The green line depicts uniform distribution. (B) The HWHH histograms for binocular oriented cells from the same patch of cells as in (A) for (i) C-iter = 0, (ii) C-iter = 500, and (iii) C-iter = 1500.

Mentions: Histogram of preferred orientation between two eyes, ΔOR, at 3000 epochs for C-iter = 0, 500, and 1500 epochs are shown in Figures 8Ai–iii. We have plotted in Figure 8Aiv the cumulative distribution of ΔOR, at 3000 epochs for three different C-iter values. The green line depicts uniform distribution. Best orientation alignment for the two eyes are obtained for C-iter = 0 epoch. However, at 0th epoch no cells are orientation tuned, thus first condition for choice of C-iter is not satisfied. For C-iter = 1500 epochs the alignment in preferred orientation is poor and the cumulative distribution is almost similar to random distribution. With C-iter = 500 epochs, at 3000 epoch we get 39% orientation selective cells in the binocular zone with orientation alignment similar to the ones reported in literature (Wang et al., 2010). The HWHH of cells for binocular input at maturity for three different C-iter values are shown in Figure 8B. The mean HWHHs are 51.45°, 57.27°, and 58.41° at C-iter = 0, 500, and 1500 epochs. Note that the mean HWHH data contains all orientation selective cells i.e., cells with HWHH ≤ 90°. If we consider only moderate to high orientation selective cells i.e., cells with OSI > 0.3 the mean HWHH improves. For instance for C-iter = 500, at 3000 epoch mean HWHH is 36° for cells with OSI > 0.3.


Development and matching of binocular orientation preference in mouse V1.

Bhaumik B, Shah NP - Front Syst Neurosci (2014)

(Ai–iii) Histogram of preferred orientation difference between the two eyes, ΔOR, at maturity (3000th epochs) for C-iter = 0, 500, and 1500 for cells from the same 35 × 60 patch of cortex used for Figure 7. (iv) The cumulative distribution of ΔOR, at 3000 epochs is shown for three different values of C-iter. The green line depicts uniform distribution. (B) The HWHH histograms for binocular oriented cells from the same patch of cells as in (A) for (i) C-iter = 0, (ii) C-iter = 500, and (iii) C-iter = 1500.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109519&req=5

Figure 8: (Ai–iii) Histogram of preferred orientation difference between the two eyes, ΔOR, at maturity (3000th epochs) for C-iter = 0, 500, and 1500 for cells from the same 35 × 60 patch of cortex used for Figure 7. (iv) The cumulative distribution of ΔOR, at 3000 epochs is shown for three different values of C-iter. The green line depicts uniform distribution. (B) The HWHH histograms for binocular oriented cells from the same patch of cells as in (A) for (i) C-iter = 0, (ii) C-iter = 500, and (iii) C-iter = 1500.
Mentions: Histogram of preferred orientation between two eyes, ΔOR, at 3000 epochs for C-iter = 0, 500, and 1500 epochs are shown in Figures 8Ai–iii. We have plotted in Figure 8Aiv the cumulative distribution of ΔOR, at 3000 epochs for three different C-iter values. The green line depicts uniform distribution. Best orientation alignment for the two eyes are obtained for C-iter = 0 epoch. However, at 0th epoch no cells are orientation tuned, thus first condition for choice of C-iter is not satisfied. For C-iter = 1500 epochs the alignment in preferred orientation is poor and the cumulative distribution is almost similar to random distribution. With C-iter = 500 epochs, at 3000 epoch we get 39% orientation selective cells in the binocular zone with orientation alignment similar to the ones reported in literature (Wang et al., 2010). The HWHH of cells for binocular input at maturity for three different C-iter values are shown in Figure 8B. The mean HWHHs are 51.45°, 57.27°, and 58.41° at C-iter = 0, 500, and 1500 epochs. Note that the mean HWHH data contains all orientation selective cells i.e., cells with HWHH ≤ 90°. If we consider only moderate to high orientation selective cells i.e., cells with OSI > 0.3 the mean HWHH improves. For instance for C-iter = 500, at 3000 epoch mean HWHH is 36° for cells with OSI > 0.3.

Bottom Line: At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective.The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells.It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

View Article: PubMed Central - PubMed

Affiliation: Electrical Engineering Department, Indian Institute of Technology Delhi New Delhi, India.

ABSTRACT
Eye-specific thalamic inputs converge in the primary visual cortex (V1) and form the basis of binocular vision. For normal binocular perceptions, such as depth and stereopsis, binocularly matched orientation preference between the two eyes is required. A critical period of binocular matching of orientation preference in mice during normal development is reported in literature. Using a reaction diffusion model we present the development of RF and orientation selectivity in mouse V1 and investigate the binocular orientation preference matching during the critical period. At the onset of the critical period the preferred orientations of the modeled cells are mostly mismatched in the two eyes and the mismatch decreases and reaches levels reported in juvenile mouse by the end of the critical period. At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective. In literature around 40% cortical cells are reported as orientation selective in mouse V1. The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells. The absence of near neighbor interaction among cortical cells during the development of thalamo-cortical wiring causes a salt and pepper organization in the orientation preference map in mice. It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

No MeSH data available.


Related in: MedlinePlus