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Development and matching of binocular orientation preference in mouse V1.

Bhaumik B, Shah NP - Front Syst Neurosci (2014)

Bottom Line: At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective.The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells.It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

View Article: PubMed Central - PubMed

Affiliation: Electrical Engineering Department, Indian Institute of Technology Delhi New Delhi, India.

ABSTRACT
Eye-specific thalamic inputs converge in the primary visual cortex (V1) and form the basis of binocular vision. For normal binocular perceptions, such as depth and stereopsis, binocularly matched orientation preference between the two eyes is required. A critical period of binocular matching of orientation preference in mice during normal development is reported in literature. Using a reaction diffusion model we present the development of RF and orientation selectivity in mouse V1 and investigate the binocular orientation preference matching during the critical period. At the onset of the critical period the preferred orientations of the modeled cells are mostly mismatched in the two eyes and the mismatch decreases and reaches levels reported in juvenile mouse by the end of the critical period. At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective. In literature around 40% cortical cells are reported as orientation selective in mouse V1. The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells. The absence of near neighbor interaction among cortical cells during the development of thalamo-cortical wiring causes a salt and pepper organization in the orientation preference map in mice. It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

No MeSH data available.


Related in: MedlinePlus

(A,C) Two orientation preference maps for a 32 × 32 section of cortex inside binocular region and monocular region, respectively. The lines depict orientation preference for cells. For cells that are not orientation tuned, no line is shown. We observe a salt and pepper orientation preference map. (B) Orientation preference histogram for binocular cells. (D) Orientation preference histogram for monocular cells. All orientations are almost equally present. (E) OD histogram of the cells in binocular region. Mean OD is −0.1031 and depicts contra-lateral dominance. (F) OD map for the section of the cortex shown in (A). The OD map is unstructured.
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Figure 6: (A,C) Two orientation preference maps for a 32 × 32 section of cortex inside binocular region and monocular region, respectively. The lines depict orientation preference for cells. For cells that are not orientation tuned, no line is shown. We observe a salt and pepper orientation preference map. (B) Orientation preference histogram for binocular cells. (D) Orientation preference histogram for monocular cells. All orientations are almost equally present. (E) OD histogram of the cells in binocular region. Mean OD is −0.1031 and depicts contra-lateral dominance. (F) OD map for the section of the cortex shown in (A). The OD map is unstructured.

Mentions: Two orientation preference maps for 32 × 32 section of cortex inside binocular region and monocular region are shown in Figures 6A,C. The white color lines depict the binocular preferred OR of cells. No orientation line is shown for the cells that are not orientation tuned. The orientation preferences of nearby cortical cells are uncorrelated and we observe a salt and pepper OR preference map. In cat visual cortex, neurons are arranged according to their preferred orientation resulting in smooth OR preference map with pinwheels. In mice there is no evidence of such smooth OR preference map (Dräger, 1975; Mangini and Pearlman, 1980; Metin et al., 1988; Bonin et al., 2011) although neurons are tuned to orientation of the visual stimulus. In a salt-and-pepper organization of OR preference map, the receptive fields with different preferred orientations could sample a visual scene uniformly. In cats and ferrets with structured OR preference maps at certain visual field positions some degree of overrepresentation of certain orientations are likely. But in combination with eye movements this disadvantage may be overcome (Kaschube, 2014).


Development and matching of binocular orientation preference in mouse V1.

Bhaumik B, Shah NP - Front Syst Neurosci (2014)

(A,C) Two orientation preference maps for a 32 × 32 section of cortex inside binocular region and monocular region, respectively. The lines depict orientation preference for cells. For cells that are not orientation tuned, no line is shown. We observe a salt and pepper orientation preference map. (B) Orientation preference histogram for binocular cells. (D) Orientation preference histogram for monocular cells. All orientations are almost equally present. (E) OD histogram of the cells in binocular region. Mean OD is −0.1031 and depicts contra-lateral dominance. (F) OD map for the section of the cortex shown in (A). The OD map is unstructured.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109519&req=5

Figure 6: (A,C) Two orientation preference maps for a 32 × 32 section of cortex inside binocular region and monocular region, respectively. The lines depict orientation preference for cells. For cells that are not orientation tuned, no line is shown. We observe a salt and pepper orientation preference map. (B) Orientation preference histogram for binocular cells. (D) Orientation preference histogram for monocular cells. All orientations are almost equally present. (E) OD histogram of the cells in binocular region. Mean OD is −0.1031 and depicts contra-lateral dominance. (F) OD map for the section of the cortex shown in (A). The OD map is unstructured.
Mentions: Two orientation preference maps for 32 × 32 section of cortex inside binocular region and monocular region are shown in Figures 6A,C. The white color lines depict the binocular preferred OR of cells. No orientation line is shown for the cells that are not orientation tuned. The orientation preferences of nearby cortical cells are uncorrelated and we observe a salt and pepper OR preference map. In cat visual cortex, neurons are arranged according to their preferred orientation resulting in smooth OR preference map with pinwheels. In mice there is no evidence of such smooth OR preference map (Dräger, 1975; Mangini and Pearlman, 1980; Metin et al., 1988; Bonin et al., 2011) although neurons are tuned to orientation of the visual stimulus. In a salt-and-pepper organization of OR preference map, the receptive fields with different preferred orientations could sample a visual scene uniformly. In cats and ferrets with structured OR preference maps at certain visual field positions some degree of overrepresentation of certain orientations are likely. But in combination with eye movements this disadvantage may be overcome (Kaschube, 2014).

Bottom Line: At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective.The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells.It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

View Article: PubMed Central - PubMed

Affiliation: Electrical Engineering Department, Indian Institute of Technology Delhi New Delhi, India.

ABSTRACT
Eye-specific thalamic inputs converge in the primary visual cortex (V1) and form the basis of binocular vision. For normal binocular perceptions, such as depth and stereopsis, binocularly matched orientation preference between the two eyes is required. A critical period of binocular matching of orientation preference in mice during normal development is reported in literature. Using a reaction diffusion model we present the development of RF and orientation selectivity in mouse V1 and investigate the binocular orientation preference matching during the critical period. At the onset of the critical period the preferred orientations of the modeled cells are mostly mismatched in the two eyes and the mismatch decreases and reaches levels reported in juvenile mouse by the end of the critical period. At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective. In literature around 40% cortical cells are reported as orientation selective in mouse V1. The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells. The absence of near neighbor interaction among cortical cells during the development of thalamo-cortical wiring causes a salt and pepper organization in the orientation preference map in mice. It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

No MeSH data available.


Related in: MedlinePlus