Limits...
Development and matching of binocular orientation preference in mouse V1.

Bhaumik B, Shah NP - Front Syst Neurosci (2014)

Bottom Line: At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective.The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells.It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

View Article: PubMed Central - PubMed

Affiliation: Electrical Engineering Department, Indian Institute of Technology Delhi New Delhi, India.

ABSTRACT
Eye-specific thalamic inputs converge in the primary visual cortex (V1) and form the basis of binocular vision. For normal binocular perceptions, such as depth and stereopsis, binocularly matched orientation preference between the two eyes is required. A critical period of binocular matching of orientation preference in mice during normal development is reported in literature. Using a reaction diffusion model we present the development of RF and orientation selectivity in mouse V1 and investigate the binocular orientation preference matching during the critical period. At the onset of the critical period the preferred orientations of the modeled cells are mostly mismatched in the two eyes and the mismatch decreases and reaches levels reported in juvenile mouse by the end of the critical period. At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective. In literature around 40% cortical cells are reported as orientation selective in mouse V1. The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells. The absence of near neighbor interaction among cortical cells during the development of thalamo-cortical wiring causes a salt and pepper organization in the orientation preference map in mice. It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

No MeSH data available.


Related in: MedlinePlus

(A) The spatial frequency response of 3 sample cells. The response at sample frequencies (0.01–0.06 cycles/° with intervals of 0.01 cycles/°) and velocity of 100°/s is fitted with cubic spline to determine optimal spatial frequency. Optimal spatial frequency for Cell 1–Cell 3 are 0.042 cycles/°, 0.022 cycles/°, and 0.048 cycles/°, respectively. (B) The Optimal spatial frequency histogram for all cells (N = 374) from a patch in binocular region that are oriented in left and right RFs and have ΔOR < 30°. (C) Optimal spatial frequency histogram for cells from (B) that also have moderate orientation tuning (OSI > 0.3). Mean in (C) is 0.038 cycles/°.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4109519&req=5

Figure 5: (A) The spatial frequency response of 3 sample cells. The response at sample frequencies (0.01–0.06 cycles/° with intervals of 0.01 cycles/°) and velocity of 100°/s is fitted with cubic spline to determine optimal spatial frequency. Optimal spatial frequency for Cell 1–Cell 3 are 0.042 cycles/°, 0.022 cycles/°, and 0.048 cycles/°, respectively. (B) The Optimal spatial frequency histogram for all cells (N = 374) from a patch in binocular region that are oriented in left and right RFs and have ΔOR < 30°. (C) Optimal spatial frequency histogram for cells from (B) that also have moderate orientation tuning (OSI > 0.3). Mean in (C) is 0.038 cycles/°.

Mentions: Reported optimal spatial frequency range across the cell population in mice ranges from 0.02–0.09 cycles/° (Gao et al., 2010) to 0.003–0.1 cycles/° (Van den Bergh et al., 2010; Vreysen et al., 2012). We have studied the spatial frequency response of our modeled cells. For obtaining spatial frequency response a centrally located cortical section in binocular region was chosen. Further, cells (N = 374) that are orientation selective in their binocular response and have difference in the preferred orientation, ΔOR < 30°, between left eye and right response were selected. The spatial frequency responses of these cells were obtained by exposing the cells to drifting gratings at preferred orientation as obtained from their binocular response, at different spatial frequencies but at same velocity (100°/s). The spatial frequency responses of three sample cells are shown in Figure 5A. The histogram for the optimal spatial frequency is shown in Figure 5B. For cells (N = 138) with at least moderate tuning (OSI > 0.3) the spatial frequency histogram is shown in Figure 5C. The mean preferred spatial frequency of these cells is 0.038 cycles/° and close to the values reported (Gao et al., 2010; Van den Bergh et al., 2010; Vreysen et al., 2012).


Development and matching of binocular orientation preference in mouse V1.

Bhaumik B, Shah NP - Front Syst Neurosci (2014)

(A) The spatial frequency response of 3 sample cells. The response at sample frequencies (0.01–0.06 cycles/° with intervals of 0.01 cycles/°) and velocity of 100°/s is fitted with cubic spline to determine optimal spatial frequency. Optimal spatial frequency for Cell 1–Cell 3 are 0.042 cycles/°, 0.022 cycles/°, and 0.048 cycles/°, respectively. (B) The Optimal spatial frequency histogram for all cells (N = 374) from a patch in binocular region that are oriented in left and right RFs and have ΔOR < 30°. (C) Optimal spatial frequency histogram for cells from (B) that also have moderate orientation tuning (OSI > 0.3). Mean in (C) is 0.038 cycles/°.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109519&req=5

Figure 5: (A) The spatial frequency response of 3 sample cells. The response at sample frequencies (0.01–0.06 cycles/° with intervals of 0.01 cycles/°) and velocity of 100°/s is fitted with cubic spline to determine optimal spatial frequency. Optimal spatial frequency for Cell 1–Cell 3 are 0.042 cycles/°, 0.022 cycles/°, and 0.048 cycles/°, respectively. (B) The Optimal spatial frequency histogram for all cells (N = 374) from a patch in binocular region that are oriented in left and right RFs and have ΔOR < 30°. (C) Optimal spatial frequency histogram for cells from (B) that also have moderate orientation tuning (OSI > 0.3). Mean in (C) is 0.038 cycles/°.
Mentions: Reported optimal spatial frequency range across the cell population in mice ranges from 0.02–0.09 cycles/° (Gao et al., 2010) to 0.003–0.1 cycles/° (Van den Bergh et al., 2010; Vreysen et al., 2012). We have studied the spatial frequency response of our modeled cells. For obtaining spatial frequency response a centrally located cortical section in binocular region was chosen. Further, cells (N = 374) that are orientation selective in their binocular response and have difference in the preferred orientation, ΔOR < 30°, between left eye and right response were selected. The spatial frequency responses of these cells were obtained by exposing the cells to drifting gratings at preferred orientation as obtained from their binocular response, at different spatial frequencies but at same velocity (100°/s). The spatial frequency responses of three sample cells are shown in Figure 5A. The histogram for the optimal spatial frequency is shown in Figure 5B. For cells (N = 138) with at least moderate tuning (OSI > 0.3) the spatial frequency histogram is shown in Figure 5C. The mean preferred spatial frequency of these cells is 0.038 cycles/° and close to the values reported (Gao et al., 2010; Van den Bergh et al., 2010; Vreysen et al., 2012).

Bottom Line: At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective.The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells.It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

View Article: PubMed Central - PubMed

Affiliation: Electrical Engineering Department, Indian Institute of Technology Delhi New Delhi, India.

ABSTRACT
Eye-specific thalamic inputs converge in the primary visual cortex (V1) and form the basis of binocular vision. For normal binocular perceptions, such as depth and stereopsis, binocularly matched orientation preference between the two eyes is required. A critical period of binocular matching of orientation preference in mice during normal development is reported in literature. Using a reaction diffusion model we present the development of RF and orientation selectivity in mouse V1 and investigate the binocular orientation preference matching during the critical period. At the onset of the critical period the preferred orientations of the modeled cells are mostly mismatched in the two eyes and the mismatch decreases and reaches levels reported in juvenile mouse by the end of the critical period. At the end of critical period 39% of cells in binocular zone in our model cortex is orientation selective. In literature around 40% cortical cells are reported as orientation selective in mouse V1. The starting and the closing time for critical period determine the orientation preference alignment between the two eyes and orientation tuning in cortical cells. The absence of near neighbor interaction among cortical cells during the development of thalamo-cortical wiring causes a salt and pepper organization in the orientation preference map in mice. It also results in much lower % of orientation selective cells in mice as compared to ferrets and cats having organized orientation maps with pinwheels.

No MeSH data available.


Related in: MedlinePlus