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Effects of cactus fiber on the excretion of dietary fat in healthy subjects: a double blind, randomized, placebo-controlled, crossover clinical investigation.

Uebelhack R, Busch R, Alt F, Beah ZM, Chong PW - Curr Ther Res Clin Exp (2014)

Bottom Line: As demonstrated by in vitro studies, cactus fiber binds to dietary fat and its use results in reduced absorption, which in turn leads to reduced energy absorption and ultimately the reduction of body weight.No adverse events were reported throughout the study period.The results of our study support the hypothesis that cactus fiber helps in reducing body weight by binding to dietary fat and increasing its excretion, thus reducing dietary fat available for absorption.

View Article: PubMed Central - PubMed

Affiliation: Universitätsmedizin Charité, Berlin, Germany.

ABSTRACT

Background: Cactus (Opuntia ficus-indica) fiber was shown to promote weight loss in a 3-month clinical investigation. As demonstrated by in vitro studies, cactus fiber binds to dietary fat and its use results in reduced absorption, which in turn leads to reduced energy absorption and ultimately the reduction of body weight.

Objective: The objective of our study was to elucidate the dietary fat binding capacity of cactus fiber through determination of fecal fat excretion in healthy volunteers.

Subjects and methods: This clinical investigation was performed as a double-blind, randomized, placebo-controlled, crossover study in healthy subjects for a period of approximately 45 days. Twenty healthy volunteer subjects were randomized to receive cactus fiber or placebo, 2 tablets thrice daily with main meals. All subjects were provided with meals during the study period (except washout) according to a standardized meal plan, with 35% of daily energy need coming from fat. Two 24-hour feces samples were collected during both the baseline and treatment periods for analysis of the fat content.

Results: Cactus fiber showed an increased fecal fat excretion compared with placebo (mean [SD] = 15.79% [5.79%] vs 4.56% [3.09%]; P < 0.001). No adverse events were reported throughout the study period.

Conclusions: Cactus fiber has been shown to significantly promote fecal fat excretion in healthy adults. The results of our study support the hypothesis that cactus fiber helps in reducing body weight by binding to dietary fat and increasing its excretion, thus reducing dietary fat available for absorption. ClinicalTrials.gov identifier: NCT01590667.

No MeSH data available.


Related in: MedlinePlus

Subject flow diagram. Twenty-one subjects were screened and 20 subjects were randomized. All 20 subjects were included in the analysis.
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f0010: Subject flow diagram. Twenty-one subjects were screened and 20 subjects were randomized. All 20 subjects were included in the analysis.

Mentions: Twenty-one subjects were screened, of whom 20 were included in B1 and randomized (Figure 2). All 20 subjects were included in the intent-to-treat population. There were 7 men (35.0%) out of the 20 subjects in the trial. The gender distribution was not significantly different between the cactus fiber group and the placebo group (P = 1.000). The baseline characteristics, including age, body weight, body mass index, and energy requirements of the cactus fiber group and placebo group were similar (Table I).


Effects of cactus fiber on the excretion of dietary fat in healthy subjects: a double blind, randomized, placebo-controlled, crossover clinical investigation.

Uebelhack R, Busch R, Alt F, Beah ZM, Chong PW - Curr Ther Res Clin Exp (2014)

Subject flow diagram. Twenty-one subjects were screened and 20 subjects were randomized. All 20 subjects were included in the analysis.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109417&req=5

f0010: Subject flow diagram. Twenty-one subjects were screened and 20 subjects were randomized. All 20 subjects were included in the analysis.
Mentions: Twenty-one subjects were screened, of whom 20 were included in B1 and randomized (Figure 2). All 20 subjects were included in the intent-to-treat population. There were 7 men (35.0%) out of the 20 subjects in the trial. The gender distribution was not significantly different between the cactus fiber group and the placebo group (P = 1.000). The baseline characteristics, including age, body weight, body mass index, and energy requirements of the cactus fiber group and placebo group were similar (Table I).

Bottom Line: As demonstrated by in vitro studies, cactus fiber binds to dietary fat and its use results in reduced absorption, which in turn leads to reduced energy absorption and ultimately the reduction of body weight.No adverse events were reported throughout the study period.The results of our study support the hypothesis that cactus fiber helps in reducing body weight by binding to dietary fat and increasing its excretion, thus reducing dietary fat available for absorption.

View Article: PubMed Central - PubMed

Affiliation: Universitätsmedizin Charité, Berlin, Germany.

ABSTRACT

Background: Cactus (Opuntia ficus-indica) fiber was shown to promote weight loss in a 3-month clinical investigation. As demonstrated by in vitro studies, cactus fiber binds to dietary fat and its use results in reduced absorption, which in turn leads to reduced energy absorption and ultimately the reduction of body weight.

Objective: The objective of our study was to elucidate the dietary fat binding capacity of cactus fiber through determination of fecal fat excretion in healthy volunteers.

Subjects and methods: This clinical investigation was performed as a double-blind, randomized, placebo-controlled, crossover study in healthy subjects for a period of approximately 45 days. Twenty healthy volunteer subjects were randomized to receive cactus fiber or placebo, 2 tablets thrice daily with main meals. All subjects were provided with meals during the study period (except washout) according to a standardized meal plan, with 35% of daily energy need coming from fat. Two 24-hour feces samples were collected during both the baseline and treatment periods for analysis of the fat content.

Results: Cactus fiber showed an increased fecal fat excretion compared with placebo (mean [SD] = 15.79% [5.79%] vs 4.56% [3.09%]; P < 0.001). No adverse events were reported throughout the study period.

Conclusions: Cactus fiber has been shown to significantly promote fecal fat excretion in healthy adults. The results of our study support the hypothesis that cactus fiber helps in reducing body weight by binding to dietary fat and increasing its excretion, thus reducing dietary fat available for absorption. ClinicalTrials.gov identifier: NCT01590667.

No MeSH data available.


Related in: MedlinePlus