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Phosphorus supplement alters postprandial lipemia of healthy male subjects: a pilot cross-over trial.

Hazim J, Hlais S, Ghattas H, Shatila D, Bassil M, Obeid O - Lipids Health Dis (2014)

Bottom Line: In the phosphorus (P) supplemented group, postprandial serum P increased (p=0.00), while changes in insulin, non-esterified fatty acids (NEFA) and triglyceride (TG) were not significantly different than that of placebo.Concurrently, phosphorus supplementation increased postprandial concentrations of apolipoprotein B48 (ApoB48) (p<0.05) and decreased that of apolipoprotein B100 (ApoB100) (p<0.05).These findings highlight the potential role of phosphorus in CVD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, P,O, Box 11-0236, Lebanon. omar.obeid@aub.edu.lb.

ABSTRACT

Background: Epidemiological studies have found a U-shaped relationship between serum phosphorus and cardiovascular disease (CVD). The mechanism(s) behind such a relationship are poorly understood. Phosphorus (P) is reported to improve insulin sensitivity, which is involved in lipid metabolism, and thus we were interested in determining the impact of phosphorus ingestion on postprandial lipemia, a recognized CVD risk factor.

Findings: A within-subject study design was conducted, whereby 8 healthy male subjects received a high fat meal (330 Kcal; 69% energy from fat; 35 mg of phosphorus) with placebo or phosphorus (500 mg) in a random order. Postprandial blood samples (~10 ml) were collected every hour for 6 hours after meal ingestion. Changes in different parameters were analyzed using a 2-factor repeated-measure ANOVA. In the phosphorus (P) supplemented group, postprandial serum P increased (p=0.00), while changes in insulin, non-esterified fatty acids (NEFA) and triglyceride (TG) were not significantly different than that of placebo. Concurrently, phosphorus supplementation increased postprandial concentrations of apolipoprotein B48 (ApoB48) (p<0.05) and decreased that of apolipoprotein B100 (ApoB100) (p<0.05).

Conclusions: Phosphorus supplementation (500 mg) of the meal seems to alter the different components of postprandial lipemia. These findings highlight the potential role of phosphorus in CVD.

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Related in: MedlinePlus

Difference from baseline (Δ) of postprandial: serum phosphate (A), insulin (B), triglycerides (C), NEFA (D), apoB100 (E), and plasma apo-B48 (F) after the ingestion of the high fat meal with placebo (diamond) or with 500 mg P (square). Two-factor repeated-measures analysis of variance (Phosphorus, Time and their Interaction, blue diamond; red square).
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Figure 1: Difference from baseline (Δ) of postprandial: serum phosphate (A), insulin (B), triglycerides (C), NEFA (D), apoB100 (E), and plasma apo-B48 (F) after the ingestion of the high fat meal with placebo (diamond) or with 500 mg P (square). Two-factor repeated-measures analysis of variance (Phosphorus, Time and their Interaction, blue diamond; red square).

Mentions: All subjects had normal BMI, waist circumference, as well as normal levels of fasting serum glucose, insulin, HOMA, TG, Total cholesterol, LDL and HDL levels (Table 1). Postprandial changes (Figure 1) in serum P were significantly different according to time (p < 0.000) and treatments (p < 0.001), while that of NEFA was significant according to time (p < 0.000) only. The pattern of changes in serum insulin and TG level varied slightly but not significantly between the two treatments.


Phosphorus supplement alters postprandial lipemia of healthy male subjects: a pilot cross-over trial.

Hazim J, Hlais S, Ghattas H, Shatila D, Bassil M, Obeid O - Lipids Health Dis (2014)

Difference from baseline (Δ) of postprandial: serum phosphate (A), insulin (B), triglycerides (C), NEFA (D), apoB100 (E), and plasma apo-B48 (F) after the ingestion of the high fat meal with placebo (diamond) or with 500 mg P (square). Two-factor repeated-measures analysis of variance (Phosphorus, Time and their Interaction, blue diamond; red square).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4109374&req=5

Figure 1: Difference from baseline (Δ) of postprandial: serum phosphate (A), insulin (B), triglycerides (C), NEFA (D), apoB100 (E), and plasma apo-B48 (F) after the ingestion of the high fat meal with placebo (diamond) or with 500 mg P (square). Two-factor repeated-measures analysis of variance (Phosphorus, Time and their Interaction, blue diamond; red square).
Mentions: All subjects had normal BMI, waist circumference, as well as normal levels of fasting serum glucose, insulin, HOMA, TG, Total cholesterol, LDL and HDL levels (Table 1). Postprandial changes (Figure 1) in serum P were significantly different according to time (p < 0.000) and treatments (p < 0.001), while that of NEFA was significant according to time (p < 0.000) only. The pattern of changes in serum insulin and TG level varied slightly but not significantly between the two treatments.

Bottom Line: In the phosphorus (P) supplemented group, postprandial serum P increased (p=0.00), while changes in insulin, non-esterified fatty acids (NEFA) and triglyceride (TG) were not significantly different than that of placebo.Concurrently, phosphorus supplementation increased postprandial concentrations of apolipoprotein B48 (ApoB48) (p<0.05) and decreased that of apolipoprotein B100 (ApoB100) (p<0.05).These findings highlight the potential role of phosphorus in CVD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, P,O, Box 11-0236, Lebanon. omar.obeid@aub.edu.lb.

ABSTRACT

Background: Epidemiological studies have found a U-shaped relationship between serum phosphorus and cardiovascular disease (CVD). The mechanism(s) behind such a relationship are poorly understood. Phosphorus (P) is reported to improve insulin sensitivity, which is involved in lipid metabolism, and thus we were interested in determining the impact of phosphorus ingestion on postprandial lipemia, a recognized CVD risk factor.

Findings: A within-subject study design was conducted, whereby 8 healthy male subjects received a high fat meal (330 Kcal; 69% energy from fat; 35 mg of phosphorus) with placebo or phosphorus (500 mg) in a random order. Postprandial blood samples (~10 ml) were collected every hour for 6 hours after meal ingestion. Changes in different parameters were analyzed using a 2-factor repeated-measure ANOVA. In the phosphorus (P) supplemented group, postprandial serum P increased (p=0.00), while changes in insulin, non-esterified fatty acids (NEFA) and triglyceride (TG) were not significantly different than that of placebo. Concurrently, phosphorus supplementation increased postprandial concentrations of apolipoprotein B48 (ApoB48) (p<0.05) and decreased that of apolipoprotein B100 (ApoB100) (p<0.05).

Conclusions: Phosphorus supplementation (500 mg) of the meal seems to alter the different components of postprandial lipemia. These findings highlight the potential role of phosphorus in CVD.

Show MeSH
Related in: MedlinePlus