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Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

Sabater AL, Velázquez-Villoria Á, Zapata MA, Figueroa MS, Suárez-Leoz M, Arrevola L, Teijeiro MÁ, García-Layana A - Biomed Res Int (2014)

Bottom Line: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis.However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery.Semimanual segmentation slightly improved the quality of the results.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

ABSTRACT

Purpose: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).

Results: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.

Conclusion: SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.

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Related in: MedlinePlus

Examples of scans with incorrect ganglion cell-inner plexiform layer segmentation due to macular morphology distortion. (a) OCT ganglion cell analysis in a patient after idiopathic macular hole surgery. (b) OCT ganglion cell analysis in a patient with an idiopathic macular hole. The arrows show an area where the automated segmentation was incorrectly performed.
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fig3: Examples of scans with incorrect ganglion cell-inner plexiform layer segmentation due to macular morphology distortion. (a) OCT ganglion cell analysis in a patient after idiopathic macular hole surgery. (b) OCT ganglion cell analysis in a patient with an idiopathic macular hole. The arrows show an area where the automated segmentation was incorrectly performed.

Mentions: The study had some limitations. First, our series of patients is relatively small, in part because the GCA software of the Cirrus HD-OCT has only recently become commercially available. Therefore, future studies should be performed to validate our results. Second, longer observation periods are needed in order to evaluate the GCIPL progress over time. Third, the automatic segmentation performed by the GCA software may be altered in some patients where the macular morphology is distorted due to the IMH (Figure 3). Actually, these measurement errors may be the reason why almost no differences were found in the average GCIPL thickness in our study. In fact, we observed that GCIPL thickness analysis in some macular quadrants was higher after surgery than before surgery, even if the analysis was performed by automated or semimanual segmentation (Tables 6 and 7, resp.). Therefore, additional studies should be performed in order to determine the ability of the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) to analyze the GCIPL in patients with different macular diseases. Alternatively, a real manual segmentation could be performed by custom OCT analysis software (i.e., OCTOR).


Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

Sabater AL, Velázquez-Villoria Á, Zapata MA, Figueroa MS, Suárez-Leoz M, Arrevola L, Teijeiro MÁ, García-Layana A - Biomed Res Int (2014)

Examples of scans with incorrect ganglion cell-inner plexiform layer segmentation due to macular morphology distortion. (a) OCT ganglion cell analysis in a patient after idiopathic macular hole surgery. (b) OCT ganglion cell analysis in a patient with an idiopathic macular hole. The arrows show an area where the automated segmentation was incorrectly performed.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109220&req=5

fig3: Examples of scans with incorrect ganglion cell-inner plexiform layer segmentation due to macular morphology distortion. (a) OCT ganglion cell analysis in a patient after idiopathic macular hole surgery. (b) OCT ganglion cell analysis in a patient with an idiopathic macular hole. The arrows show an area where the automated segmentation was incorrectly performed.
Mentions: The study had some limitations. First, our series of patients is relatively small, in part because the GCA software of the Cirrus HD-OCT has only recently become commercially available. Therefore, future studies should be performed to validate our results. Second, longer observation periods are needed in order to evaluate the GCIPL progress over time. Third, the automatic segmentation performed by the GCA software may be altered in some patients where the macular morphology is distorted due to the IMH (Figure 3). Actually, these measurement errors may be the reason why almost no differences were found in the average GCIPL thickness in our study. In fact, we observed that GCIPL thickness analysis in some macular quadrants was higher after surgery than before surgery, even if the analysis was performed by automated or semimanual segmentation (Tables 6 and 7, resp.). Therefore, additional studies should be performed in order to determine the ability of the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) to analyze the GCIPL in patients with different macular diseases. Alternatively, a real manual segmentation could be performed by custom OCT analysis software (i.e., OCTOR).

Bottom Line: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis.However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery.Semimanual segmentation slightly improved the quality of the results.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

ABSTRACT

Purpose: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).

Results: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.

Conclusion: SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.

Show MeSH
Related in: MedlinePlus