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Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

Sabater AL, Velázquez-Villoria Á, Zapata MA, Figueroa MS, Suárez-Leoz M, Arrevola L, Teijeiro MÁ, García-Layana A - Biomed Res Int (2014)

Bottom Line: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis.However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery.Semimanual segmentation slightly improved the quality of the results.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

ABSTRACT

Purpose: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).

Results: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.

Conclusion: SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.

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Related in: MedlinePlus

This example shows the relocation of the area of analysis (semimanual segmentation). The center was manually displaced following the direction of the black arrow (b).
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fig2: This example shows the relocation of the area of analysis (semimanual segmentation). The center was manually displaced following the direction of the black arrow (b).

Mentions: A comparison between preoperative and postoperative macular GCIPL thickness values was also performed by semimanual segmentation. The Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) GCIPL analysis software is not capable of real manual segmentation of the macular layers, but it does allow relocation of the area of analysis (Figure 2). This procedure was performed in every scan by an experienced clinical technician in order to improve the quality of the measurements by repositioning the area of analysis in the real center of the fovea.


Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

Sabater AL, Velázquez-Villoria Á, Zapata MA, Figueroa MS, Suárez-Leoz M, Arrevola L, Teijeiro MÁ, García-Layana A - Biomed Res Int (2014)

This example shows the relocation of the area of analysis (semimanual segmentation). The center was manually displaced following the direction of the black arrow (b).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109220&req=5

fig2: This example shows the relocation of the area of analysis (semimanual segmentation). The center was manually displaced following the direction of the black arrow (b).
Mentions: A comparison between preoperative and postoperative macular GCIPL thickness values was also performed by semimanual segmentation. The Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) GCIPL analysis software is not capable of real manual segmentation of the macular layers, but it does allow relocation of the area of analysis (Figure 2). This procedure was performed in every scan by an experienced clinical technician in order to improve the quality of the measurements by repositioning the area of analysis in the real center of the fovea.

Bottom Line: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis.However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery.Semimanual segmentation slightly improved the quality of the results.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

ABSTRACT

Purpose: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).

Results: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.

Conclusion: SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.

Show MeSH
Related in: MedlinePlus