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Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

Sabater AL, Velázquez-Villoria Á, Zapata MA, Figueroa MS, Suárez-Leoz M, Arrevola L, Teijeiro MÁ, García-Layana A - Biomed Res Int (2014)

Bottom Line: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis.However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery.Semimanual segmentation slightly improved the quality of the results.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

ABSTRACT

Purpose: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).

Results: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.

Conclusion: SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.

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Related in: MedlinePlus

Macular analysis of the left eye and ganglion cell analysis of both eyes of a 78-year-old woman at 6 months after vitrectomy with Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole. (a) OCT cross-section analysis showing cube volume and cube thickness. (b) Average, minimum, and sectorial macular thickness of the ganglion cell-inner plexiform layer of both eyes. A macular temporal defect may be appreciated in the left eye.
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fig1: Macular analysis of the left eye and ganglion cell analysis of both eyes of a 78-year-old woman at 6 months after vitrectomy with Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole. (a) OCT cross-section analysis showing cube volume and cube thickness. (b) Average, minimum, and sectorial macular thickness of the ganglion cell-inner plexiform layer of both eyes. A macular temporal defect may be appreciated in the left eye.

Mentions: This study was a multicenter (n = 5), retrospective, and observational study of 32 patients. The institutional review board approval of every center was obtained. All of the patients underwent a vitrectomy associated with BBG-assisted peeling of the retinal ILM as a consequence of an IMH between January 2011 and July 2012. Seven patients were excluded for the following reasons: a history of glaucoma (1), failure to correctly identify the limits of the GCIPL by the ganglion cell analysis software by automated or semimanual segmentation (4), or macular holes greater than the central area of analysis where the GCA software does not measure the GCIPL thickness (2) (Figure 1). Therefore, a total of 25 eyes of 25 patients were included in this study.


Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

Sabater AL, Velázquez-Villoria Á, Zapata MA, Figueroa MS, Suárez-Leoz M, Arrevola L, Teijeiro MÁ, García-Layana A - Biomed Res Int (2014)

Macular analysis of the left eye and ganglion cell analysis of both eyes of a 78-year-old woman at 6 months after vitrectomy with Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole. (a) OCT cross-section analysis showing cube volume and cube thickness. (b) Average, minimum, and sectorial macular thickness of the ganglion cell-inner plexiform layer of both eyes. A macular temporal defect may be appreciated in the left eye.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109220&req=5

fig1: Macular analysis of the left eye and ganglion cell analysis of both eyes of a 78-year-old woman at 6 months after vitrectomy with Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole. (a) OCT cross-section analysis showing cube volume and cube thickness. (b) Average, minimum, and sectorial macular thickness of the ganglion cell-inner plexiform layer of both eyes. A macular temporal defect may be appreciated in the left eye.
Mentions: This study was a multicenter (n = 5), retrospective, and observational study of 32 patients. The institutional review board approval of every center was obtained. All of the patients underwent a vitrectomy associated with BBG-assisted peeling of the retinal ILM as a consequence of an IMH between January 2011 and July 2012. Seven patients were excluded for the following reasons: a history of glaucoma (1), failure to correctly identify the limits of the GCIPL by the ganglion cell analysis software by automated or semimanual segmentation (4), or macular holes greater than the central area of analysis where the GCA software does not measure the GCIPL thickness (2) (Figure 1). Therefore, a total of 25 eyes of 25 patients were included in this study.

Bottom Line: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis.However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery.Semimanual segmentation slightly improved the quality of the results.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

ABSTRACT

Purpose: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).

Results: No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.

Conclusion: SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.

Show MeSH
Related in: MedlinePlus