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Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment.

Moraes ML, Ramalho DM, Delogo KN, Miranda PF, Mesquita ED, Oliveira HM, Ruffino-Netto A, Almeida PC, Hauser-Davis RA, Campos RC, Kritski AL, Oliveira MM - J Bras Pneumol (2014 May-Jun)

Bottom Line: The mean age of the patients was 38.4 ± 11.4 years.Of the 35 patients, 25 (71%) described themselves as alcoholic; 20 (57.0%) were smokers; and 21 (60.0%) and 32 (91.4%) presented with muscle mass depletion as determined by measuring the triceps skinfold thickness and arm muscle area, respectively.Of 24 patients, 12 (39.2%) were classified as moderately or severely emaciated, and 15 (62.5%) had lost > 10% of their body weight by six months before diagnosis.

View Article: PubMed Central - PubMed

Affiliation: McGill University, Montreal, QC, Canada.

ABSTRACT

Objective: To determine whether serum selenium levels are associated with the conversion of bacteriological tests in patients diagnosed with active pulmonary tuberculosis after eight weeks of standard treatment.

Methods: We evaluated 35 healthy male controls and 35 male patients with pulmonary tuberculosis, the latter being evaluated at baseline, as well as at 30 and 60 days of antituberculosis treatment. For all participants, we measured anthropometric indices, as well as determining serum levels of albumin, C-reactive protein (CRP) and selenium. Because there are no reference values for the Brazilian population, we used the median of the serum selenium level of the controls as the cut-off point. At 30 and 60 days of antituberculosis treatment, we repeated the biochemical tests, as well as collecting sputum for smear microscopy and culture from the patients.

Results: The mean age of the patients was 38.4 ± 11.4 years. Of the 35 patients, 25 (71%) described themselves as alcoholic; 20 (57.0%) were smokers; and 21 (60.0%) and 32 (91.4%) presented with muscle mass depletion as determined by measuring the triceps skinfold thickness and arm muscle area, respectively. Of 24 patients, 12 (39.2%) were classified as moderately or severely emaciated, and 15 (62.5%) had lost > 10% of their body weight by six months before diagnosis. At baseline, the tuberculosis group had lower serum selenium levels than did the control group. The conversion of bacteriological tests was associated with the CRP/albumin ratio and serum selenium levels 60 days after treatment initiation.

Conclusions: Higher serum selenium levels after 60 days of treatment were associated with the conversion of bacteriological tests in pulmonary tuberculosis patients.

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Related in: MedlinePlus

Study and control groups at baseline, at 30 days after antituberculosistreatment initiation, and at 60 days after antituberculosis treatmentinitiation. TB+: positive sputum culture or positive sputum smear microscopyresults at that study time point; and TB−: negative sputum culture and negativesputum smear microscopy results at that study time point.
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f01: Study and control groups at baseline, at 30 days after antituberculosistreatment initiation, and at 60 days after antituberculosis treatmentinitiation. TB+: positive sputum culture or positive sputum smear microscopyresults at that study time point; and TB−: negative sputum culture and negativesputum smear microscopy results at that study time point.

Mentions: We included 35 pulmonary tuberculosis patients in the study group at baseline. Amongthese, 6 were recurrent tuberculosis patients. After 30 days of treatment, only 29patients presented spontaneous sputum production, and, after 60 days of treatment, 34patients showed spontaneous sputum production (Figure1).


Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment.

Moraes ML, Ramalho DM, Delogo KN, Miranda PF, Mesquita ED, Oliveira HM, Ruffino-Netto A, Almeida PC, Hauser-Davis RA, Campos RC, Kritski AL, Oliveira MM - J Bras Pneumol (2014 May-Jun)

Study and control groups at baseline, at 30 days after antituberculosistreatment initiation, and at 60 days after antituberculosis treatmentinitiation. TB+: positive sputum culture or positive sputum smear microscopyresults at that study time point; and TB−: negative sputum culture and negativesputum smear microscopy results at that study time point.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109199&req=5

f01: Study and control groups at baseline, at 30 days after antituberculosistreatment initiation, and at 60 days after antituberculosis treatmentinitiation. TB+: positive sputum culture or positive sputum smear microscopyresults at that study time point; and TB−: negative sputum culture and negativesputum smear microscopy results at that study time point.
Mentions: We included 35 pulmonary tuberculosis patients in the study group at baseline. Amongthese, 6 were recurrent tuberculosis patients. After 30 days of treatment, only 29patients presented spontaneous sputum production, and, after 60 days of treatment, 34patients showed spontaneous sputum production (Figure1).

Bottom Line: The mean age of the patients was 38.4 ± 11.4 years.Of the 35 patients, 25 (71%) described themselves as alcoholic; 20 (57.0%) were smokers; and 21 (60.0%) and 32 (91.4%) presented with muscle mass depletion as determined by measuring the triceps skinfold thickness and arm muscle area, respectively.Of 24 patients, 12 (39.2%) were classified as moderately or severely emaciated, and 15 (62.5%) had lost > 10% of their body weight by six months before diagnosis.

View Article: PubMed Central - PubMed

Affiliation: McGill University, Montreal, QC, Canada.

ABSTRACT

Objective: To determine whether serum selenium levels are associated with the conversion of bacteriological tests in patients diagnosed with active pulmonary tuberculosis after eight weeks of standard treatment.

Methods: We evaluated 35 healthy male controls and 35 male patients with pulmonary tuberculosis, the latter being evaluated at baseline, as well as at 30 and 60 days of antituberculosis treatment. For all participants, we measured anthropometric indices, as well as determining serum levels of albumin, C-reactive protein (CRP) and selenium. Because there are no reference values for the Brazilian population, we used the median of the serum selenium level of the controls as the cut-off point. At 30 and 60 days of antituberculosis treatment, we repeated the biochemical tests, as well as collecting sputum for smear microscopy and culture from the patients.

Results: The mean age of the patients was 38.4 ± 11.4 years. Of the 35 patients, 25 (71%) described themselves as alcoholic; 20 (57.0%) were smokers; and 21 (60.0%) and 32 (91.4%) presented with muscle mass depletion as determined by measuring the triceps skinfold thickness and arm muscle area, respectively. Of 24 patients, 12 (39.2%) were classified as moderately or severely emaciated, and 15 (62.5%) had lost > 10% of their body weight by six months before diagnosis. At baseline, the tuberculosis group had lower serum selenium levels than did the control group. The conversion of bacteriological tests was associated with the CRP/albumin ratio and serum selenium levels 60 days after treatment initiation.

Conclusions: Higher serum selenium levels after 60 days of treatment were associated with the conversion of bacteriological tests in pulmonary tuberculosis patients.

Show MeSH
Related in: MedlinePlus