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A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect.

Sham TT, Chan CO, Wang YH, Yang JM, Mok DK, Chan SW - Biomed Res Int (2014)

Bottom Line: For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large.This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms.Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.

ABSTRACT
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

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The endothelial dysfunction development is summarized and potential therapeutic interventions in the pathway using TCMs are indicated.
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fig3: The endothelial dysfunction development is summarized and potential therapeutic interventions in the pathway using TCMs are indicated.

Mentions: Ox-LDL activates the differentiation of monocytes into macrophages. It also inhibits the production of vasodilators such as nitric oxide (NO) [35] released by the endothelial cells [36]. The ox-LDL is mostly taken up by macrophage scavenger receptors [37] and accumulates to become large foam cells which become fatty streak with T cells and smooth muscles. The fatty streak then progresses into an intermediate lesion, finally into a fibrous plaque which enlarges and projects into the arterial lumen and impede the flow of blood, thus inducing atherosclerosis. Thus, a strong association exists between LDL-C levels and incidence of coronary artery diseases [38, 39]. Figure 3 summarized the development of endothelial dysfunction.


A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect.

Sham TT, Chan CO, Wang YH, Yang JM, Mok DK, Chan SW - Biomed Res Int (2014)

The endothelial dysfunction development is summarized and potential therapeutic interventions in the pathway using TCMs are indicated.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109135&req=5

fig3: The endothelial dysfunction development is summarized and potential therapeutic interventions in the pathway using TCMs are indicated.
Mentions: Ox-LDL activates the differentiation of monocytes into macrophages. It also inhibits the production of vasodilators such as nitric oxide (NO) [35] released by the endothelial cells [36]. The ox-LDL is mostly taken up by macrophage scavenger receptors [37] and accumulates to become large foam cells which become fatty streak with T cells and smooth muscles. The fatty streak then progresses into an intermediate lesion, finally into a fibrous plaque which enlarges and projects into the arterial lumen and impede the flow of blood, thus inducing atherosclerosis. Thus, a strong association exists between LDL-C levels and incidence of coronary artery diseases [38, 39]. Figure 3 summarized the development of endothelial dysfunction.

Bottom Line: For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large.This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms.Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.

ABSTRACT
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

Show MeSH
Related in: MedlinePlus