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A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect.

Sham TT, Chan CO, Wang YH, Yang JM, Mok DK, Chan SW - Biomed Res Int (2014)

Bottom Line: For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large.This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms.Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.

ABSTRACT
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

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The simplified mevalonate pathway of cholesterol production. Potential therapeutic interventions in the pathway using conventional medications and TCMs are indicated. Dotted arrows: skipped pathway.
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fig1: The simplified mevalonate pathway of cholesterol production. Potential therapeutic interventions in the pathway using conventional medications and TCMs are indicated. Dotted arrows: skipped pathway.

Mentions: Lipid metabolisms involve different lipoproteins in the anabolism and catabolism of these substances (Figures 1to 2) [3, 9, 14, 17, 18]. TG, phospholipids, and cholesterol esters (CE) are the predominant dietary lipids. These lipids, mainly TG, are hydrolyzed by different pancreatic lipases in the intestine and then absorbed by intestinal mucosal cells and secreted into mesenteric lymphatic vessels in the form of chylomicrons with apoB-48. The newly synthesized TG and CE in the chylomicrons are hydrolyzed by lipoprotein lipase (LPL) to yield chylomicron remnant particles which are cleared by LDL receptors (LDLR) and LDLR-related proteins to the liver. The liver secretes very low-density lipoproteins (VLDL) that contain specific apoB-100, apoC-II, and apoE that bind to enzymes or receptors to facilitate the lipid transfer to the peripheral tissues including vessels for metabolism or storage. ApoB-100 is the main apolipoprotein needed for LDL uptake by the liver. TG is hydrolyzed by LPL in VLDL which is further transformed into TG-reduced intermediate-density lipoprotein (IDL) followed by LDL. LDL is recirculated into the liver or peripheral tissues [19].


A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect.

Sham TT, Chan CO, Wang YH, Yang JM, Mok DK, Chan SW - Biomed Res Int (2014)

The simplified mevalonate pathway of cholesterol production. Potential therapeutic interventions in the pathway using conventional medications and TCMs are indicated. Dotted arrows: skipped pathway.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109135&req=5

fig1: The simplified mevalonate pathway of cholesterol production. Potential therapeutic interventions in the pathway using conventional medications and TCMs are indicated. Dotted arrows: skipped pathway.
Mentions: Lipid metabolisms involve different lipoproteins in the anabolism and catabolism of these substances (Figures 1to 2) [3, 9, 14, 17, 18]. TG, phospholipids, and cholesterol esters (CE) are the predominant dietary lipids. These lipids, mainly TG, are hydrolyzed by different pancreatic lipases in the intestine and then absorbed by intestinal mucosal cells and secreted into mesenteric lymphatic vessels in the form of chylomicrons with apoB-48. The newly synthesized TG and CE in the chylomicrons are hydrolyzed by lipoprotein lipase (LPL) to yield chylomicron remnant particles which are cleared by LDL receptors (LDLR) and LDLR-related proteins to the liver. The liver secretes very low-density lipoproteins (VLDL) that contain specific apoB-100, apoC-II, and apoE that bind to enzymes or receptors to facilitate the lipid transfer to the peripheral tissues including vessels for metabolism or storage. ApoB-100 is the main apolipoprotein needed for LDL uptake by the liver. TG is hydrolyzed by LPL in VLDL which is further transformed into TG-reduced intermediate-density lipoprotein (IDL) followed by LDL. LDL is recirculated into the liver or peripheral tissues [19].

Bottom Line: For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large.This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms.Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.

ABSTRACT
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

Show MeSH
Related in: MedlinePlus