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Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review.

Gangwar M, Goel RK, Nath G - Biomed Res Int (2014)

Bottom Line: We have selected all the pharmacological aspects and toxicological and all its biological related studies.However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit.This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Gastrointestinal Infections and Molecular Diagnosis, Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India ; Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

ABSTRACT
Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals that Mallotus philippinensis is a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

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Rottlerin and its major biological activities.
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fig18: Rottlerin and its major biological activities.

Mentions: Mallotus (family: Euphorbiaceae) is a large genus of trees and shrubs distributed chiefly in the tropical and subtropical regions of the Old World with around 20 species in India [1]. Mallotus philippinensis Muell. (commonly called Kamala, Kampillaka, and Kapila, and locally known as Shendri) is a very common perennial shrub or small tree found in outer Himalayas ascending to 1500 meters. Mature fruits have glandular hairs collected as reddish brown powder which is collected in cloth by shaking and rubbing the fruits by hand. The collected material is fine, granular powder, dull red, or madder red-colored and floats on water. This plant is traditionally used for antifilarial [2], antibacterial, anti-inflammatory, and immune-regulatory activity [3] and also used as purgative, anthelmintic, vulnerary, detergent, maturant, carminative, alexiteric and is useful in treatment of bronchitis, abdominal diseases, spleen enlargement, antimicrobial, antiparasitic, and so forth (Figure 18).


Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review.

Gangwar M, Goel RK, Nath G - Biomed Res Int (2014)

Rottlerin and its major biological activities.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109133&req=5

fig18: Rottlerin and its major biological activities.
Mentions: Mallotus (family: Euphorbiaceae) is a large genus of trees and shrubs distributed chiefly in the tropical and subtropical regions of the Old World with around 20 species in India [1]. Mallotus philippinensis Muell. (commonly called Kamala, Kampillaka, and Kapila, and locally known as Shendri) is a very common perennial shrub or small tree found in outer Himalayas ascending to 1500 meters. Mature fruits have glandular hairs collected as reddish brown powder which is collected in cloth by shaking and rubbing the fruits by hand. The collected material is fine, granular powder, dull red, or madder red-colored and floats on water. This plant is traditionally used for antifilarial [2], antibacterial, anti-inflammatory, and immune-regulatory activity [3] and also used as purgative, anthelmintic, vulnerary, detergent, maturant, carminative, alexiteric and is useful in treatment of bronchitis, abdominal diseases, spleen enlargement, antimicrobial, antiparasitic, and so forth (Figure 18).

Bottom Line: We have selected all the pharmacological aspects and toxicological and all its biological related studies.However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit.This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Gastrointestinal Infections and Molecular Diagnosis, Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India ; Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

ABSTRACT
Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals that Mallotus philippinensis is a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

Show MeSH
Related in: MedlinePlus