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Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review.

Gangwar M, Goel RK, Nath G - Biomed Res Int (2014)

Bottom Line: We have selected all the pharmacological aspects and toxicological and all its biological related studies.However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit.This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Gastrointestinal Infections and Molecular Diagnosis, Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India ; Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

ABSTRACT
Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals that Mallotus philippinensis is a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

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Kamalachalcone A.
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fig8: Kamalachalcone A.

Mentions: Two new chalcone derivatives (flavonoids), kamalachalcones A and B (Figures 8-9) with a unique ring system caused by dimerization between a dimethylchromene ring and a phenoxyl group, were isolated from kamala (M. philippinensis) [13]. Three other novel chalcone derivatives, mallotophilippens C, D, and E (Figures 10, 11, 12, 13 and 14), were isolated from the fruits of M. philippinensis [14], lignans, chalcones, and dimeric chalcone derivatives [15].


Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review.

Gangwar M, Goel RK, Nath G - Biomed Res Int (2014)

Kamalachalcone A.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109133&req=5

fig8: Kamalachalcone A.
Mentions: Two new chalcone derivatives (flavonoids), kamalachalcones A and B (Figures 8-9) with a unique ring system caused by dimerization between a dimethylchromene ring and a phenoxyl group, were isolated from kamala (M. philippinensis) [13]. Three other novel chalcone derivatives, mallotophilippens C, D, and E (Figures 10, 11, 12, 13 and 14), were isolated from the fruits of M. philippinensis [14], lignans, chalcones, and dimeric chalcone derivatives [15].

Bottom Line: We have selected all the pharmacological aspects and toxicological and all its biological related studies.However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit.This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Gastrointestinal Infections and Molecular Diagnosis, Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India ; Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

ABSTRACT
Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals that Mallotus philippinensis is a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

Show MeSH
Related in: MedlinePlus