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Vitamin E in sarcopenia: current evidences on its role in prevention and treatment.

Khor SC, Abdul Karim N, Ngah WZ, Yusof YA, Makpol S - Oxid Med Cell Longev (2014)

Bottom Line: Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways.Previous studies have shown its possible beneficial effects on aging and age-related diseases.Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

ABSTRACT
Sarcopenia is a geriatric syndrome that is characterized by gradual loss of muscle mass and strength with increasing age. Although the underlying mechanism is still unknown, the contribution of increased oxidative stress in advanced age has been recognized as one of the risk factors of sarcopenia. Thus, eliminating reactive oxygen species (ROS) can be a strategy to combat sarcopenia. In this review, we discuss the potential role of vitamin E in the prevention and treatment of sarcopenia. Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways. Previous studies have shown its possible beneficial effects on aging and age-related diseases. Although there are evidences suggesting an association between vitamin E and muscle health, they are still inconclusive compared to other more extensively studied chronic diseases such as neurodegenerative diseases and cardiovascular diseases. Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.

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Related in: MedlinePlus

Schematic diagram of the risk factors underlying the progression of sarcopenia. Despite genetic determination, most of the age-related changes are modifiable and can be the target in preventing sarcopenia. Among these factors, increased oxidative stress in aging is more likely to modulate a bunch of signaling cascades that will lead to sarcopenia.
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Related In: Results  -  Collection


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fig1: Schematic diagram of the risk factors underlying the progression of sarcopenia. Despite genetic determination, most of the age-related changes are modifiable and can be the target in preventing sarcopenia. Among these factors, increased oxidative stress in aging is more likely to modulate a bunch of signaling cascades that will lead to sarcopenia.

Mentions: The underlying cause of sarcopenia remains unknown. Although some researchers claimed that environmental factors play the biggest role during advanced age, the influence of genetics has to be considered [20]. Figure 1 illustrates the various possible underlying factors that contribute to the onset of sarcopenia as reported in several studies.


Vitamin E in sarcopenia: current evidences on its role in prevention and treatment.

Khor SC, Abdul Karim N, Ngah WZ, Yusof YA, Makpol S - Oxid Med Cell Longev (2014)

Schematic diagram of the risk factors underlying the progression of sarcopenia. Despite genetic determination, most of the age-related changes are modifiable and can be the target in preventing sarcopenia. Among these factors, increased oxidative stress in aging is more likely to modulate a bunch of signaling cascades that will lead to sarcopenia.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4109111&req=5

fig1: Schematic diagram of the risk factors underlying the progression of sarcopenia. Despite genetic determination, most of the age-related changes are modifiable and can be the target in preventing sarcopenia. Among these factors, increased oxidative stress in aging is more likely to modulate a bunch of signaling cascades that will lead to sarcopenia.
Mentions: The underlying cause of sarcopenia remains unknown. Although some researchers claimed that environmental factors play the biggest role during advanced age, the influence of genetics has to be considered [20]. Figure 1 illustrates the various possible underlying factors that contribute to the onset of sarcopenia as reported in several studies.

Bottom Line: Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways.Previous studies have shown its possible beneficial effects on aging and age-related diseases.Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

ABSTRACT
Sarcopenia is a geriatric syndrome that is characterized by gradual loss of muscle mass and strength with increasing age. Although the underlying mechanism is still unknown, the contribution of increased oxidative stress in advanced age has been recognized as one of the risk factors of sarcopenia. Thus, eliminating reactive oxygen species (ROS) can be a strategy to combat sarcopenia. In this review, we discuss the potential role of vitamin E in the prevention and treatment of sarcopenia. Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways. Previous studies have shown its possible beneficial effects on aging and age-related diseases. Although there are evidences suggesting an association between vitamin E and muscle health, they are still inconclusive compared to other more extensively studied chronic diseases such as neurodegenerative diseases and cardiovascular diseases. Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.

Show MeSH
Related in: MedlinePlus