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Smokeless tobacco and oral cancer in South Asia: a systematic review with meta-analysis.

Khan Z, Tönnies J, Müller S - J Cancer Epidemiol (2014)

Bottom Line: Effect estimates (odds ratios (OR)) were abstracted or calculated from the given data.Results and Conclusion.Public health policies in affected countries should consider SLT specific cessation programs in addition to campaigns and activities incorporated into smoking cessation programs.

View Article: PubMed Central - PubMed

Affiliation: Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraße 30, 28359 Bremen, Germany ; Khyber Medical University, Peshawar 25000, Pakistan.

ABSTRACT
Introduction. Smokeless tobacco is considered one of the major risk factors for oral cancer. It is estimated that over 90% of the global smokeless tobacco use burden is in South Asia. This paper aims to systematically review publications reporting epidemiological observational studies published in South Asia from 1984 till 2013. Methods. An electronic search in "Medline" and "ISI Web of Knowledge" yielded 734 publications out of which 21 were included in this review. All publications were assessed for quality using a standard quality assessment tool. Effect estimates (odds ratios (OR)) were abstracted or calculated from the given data. A random effects meta-analysis was performed to assess the risk of oral cancer with the use of different forms of smokeless tobacco. Results and Conclusion. The pooled OR for chewing tobacco and risk of oral cancer was 4.7 [3.1-7.1] and for paan with tobacco and risk of oral cancer was 7.1 [4.5-11.1]. The findings of this study suggest a strong causal link between oral cancer and various forms of smokeless tobacco. Public health policies in affected countries should consider SLT specific cessation programs in addition to campaigns and activities incorporated into smoking cessation programs.

No MeSH data available.


Related in: MedlinePlus

Flow chart of selection process of articles included in the review.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Flow chart of selection process of articles included in the review.

Mentions: A total of 734 publications were identified from both database searches (Medline, ISI Web of Knowledge) (Figure 1). One more paper was identified from a supplementary web search but it just reported the findings from one of the included studies and hence was excluded. After the first round of exclusion 137 publications remained; after reading the abstracts, 38 publications were selected and their full text versions obtained. 4 publications were excluded after examining the full paper. This left us with a total of 34 publications. 21 publications reported oral cancer as the outcome or one of the outcomes and 13 publications reported just OPMD as the outcome. The publications corresponding to OPMD were excluded at this stage.


Smokeless tobacco and oral cancer in South Asia: a systematic review with meta-analysis.

Khan Z, Tönnies J, Müller S - J Cancer Epidemiol (2014)

Flow chart of selection process of articles included in the review.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4109110&req=5

fig1: Flow chart of selection process of articles included in the review.
Mentions: A total of 734 publications were identified from both database searches (Medline, ISI Web of Knowledge) (Figure 1). One more paper was identified from a supplementary web search but it just reported the findings from one of the included studies and hence was excluded. After the first round of exclusion 137 publications remained; after reading the abstracts, 38 publications were selected and their full text versions obtained. 4 publications were excluded after examining the full paper. This left us with a total of 34 publications. 21 publications reported oral cancer as the outcome or one of the outcomes and 13 publications reported just OPMD as the outcome. The publications corresponding to OPMD were excluded at this stage.

Bottom Line: Effect estimates (odds ratios (OR)) were abstracted or calculated from the given data.Results and Conclusion.Public health policies in affected countries should consider SLT specific cessation programs in addition to campaigns and activities incorporated into smoking cessation programs.

View Article: PubMed Central - PubMed

Affiliation: Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstraße 30, 28359 Bremen, Germany ; Khyber Medical University, Peshawar 25000, Pakistan.

ABSTRACT
Introduction. Smokeless tobacco is considered one of the major risk factors for oral cancer. It is estimated that over 90% of the global smokeless tobacco use burden is in South Asia. This paper aims to systematically review publications reporting epidemiological observational studies published in South Asia from 1984 till 2013. Methods. An electronic search in "Medline" and "ISI Web of Knowledge" yielded 734 publications out of which 21 were included in this review. All publications were assessed for quality using a standard quality assessment tool. Effect estimates (odds ratios (OR)) were abstracted or calculated from the given data. A random effects meta-analysis was performed to assess the risk of oral cancer with the use of different forms of smokeless tobacco. Results and Conclusion. The pooled OR for chewing tobacco and risk of oral cancer was 4.7 [3.1-7.1] and for paan with tobacco and risk of oral cancer was 7.1 [4.5-11.1]. The findings of this study suggest a strong causal link between oral cancer and various forms of smokeless tobacco. Public health policies in affected countries should consider SLT specific cessation programs in addition to campaigns and activities incorporated into smoking cessation programs.

No MeSH data available.


Related in: MedlinePlus